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In this paper, we study a system of three evolutionary operator equations involving fractional powers of selfadjoint, monotone, unbounded, linear operators having compact resolvents. This system constitutes a generalized and relaxed version…

偏微分方程分析 · 数学 2019-08-29 Pierluigi Colli , Gianni Gilardi , Jürgen Sprekels

This paper provides a unified mathematical analysis of a family of non-local diffuse interface models for tumor growth describing evolutions driven by long-range interactions. These integro-partial differential equations model cell-to-cell…

偏微分方程分析 · 数学 2021-07-07 Luca Scarpa , Andrea Signori

We prove that there exists a~large-data and global-in-time weak solution to a~system of partial differential equations describing an unsteady flow of an incompressible heat-conducting rate-type viscoelastic stress-diffusive fluid filling up…

偏微分方程分析 · 数学 2025-04-18 Michal Bathory , Miroslav Bulíček , Josef Málek

We consider a one--spatial dimensional tumour growth model [2, 3, 4] that consists of three dependent variables of space and time: volume fraction of tumour cells, velocity of tumour cells, and nutrient concentration. The model variables…

数值分析 · 数学 2020-07-01 Jerome Droniou , Neela Nataraj , Gopikrishnan Chirappurathu Remesan

We introduce here a new diffuse interface thermodynamically consistent non-isothermal model for tumor growth in presence of a nutrient in a domain $\Omega \subset \mathbb{R}^3$. In particular our system describes the growth of a tumor…

偏微分方程分析 · 数学 2022-12-19 Erica Ipocoana

We consider a biphasic continuum model for avascular tumour growth in two spatial dimensions, in which a cell phase and a fluid phase follow conservation of mass and momentum. A limiting nutrient that follows a diffusion process controls…

数值分析 · 数学 2020-10-21 Jerome Droniou , Jennifer A. Flegg , Gopikrishnan C. Remesan

In this paper, we address an optimal distributed control problem for a non-local model of phase-field type, describing the evolution of tumour cells in presence of a nutrient. The model couples a non-local and viscous Cahn-Hilliard equation…

偏微分方程分析 · 数学 2023-10-25 Matteo Fornoni

We consider a diffuse interface model for tumor growth recently proposed in [Y. Chen, S.M. Wise, V.B. Shenoy, J.S. Lowengrub, A stable scheme for a nonlinear, multiphase tumor growth model with an elastic membrane, Int. J. Numer. Methods…

偏微分方程分析 · 数学 2015-07-29 Mimi Dai , Eduard Feireisl , Elisabetta Rocca , Giulio Schimperna , Maria Schonbek

This article is concerned with a gradient-flow approach to a Cahn-Hilliard model for viscoelastic phase separation introduced by Zhou et al. (Phys. Rev. E, 2006) in its variant with constant mobility. By means of time-incremental…

偏微分方程分析 · 数学 2025-08-22 Moritz Immanuel Gau , Katharina Hopf

We consider the inverse problem of parameter estimation in a diffuse interface model for tumour growth. The model consists of a fourth-order Cahn-Hilliard system and contains three phenomenological parameters: the tumour proliferation rate,…

数值分析 · 数学 2019-05-10 Christian Kahle , Kei Fong Lam , Jonas Latz , Elisabeth Ullmann

\emph{In vitro} experiments in which tumour cells are seeded in a gelatinous medium, or hydrogel, show how mechanical interactions between tumour cells and the tissue in which they are embedded, together with local levels of an…

组织与器官 · 定量生物学 2022-06-13 Gopikrishnan C. Remesan , Jennifer A Flegg , Helen M Byrne

The global existence of bounded weak solutions to a diffusion system modeling biofilm growth is proven. The equations consist of a reaction-diffusion equation for the substrate concentration and a fourth-order Cahn-Hilliard-type equation…

偏微分方程分析 · 数学 2023-07-20 Christoph Helmer , Ansgar Jüngel

We derive a class of Navier--Stokes--Cahn--Hilliard systems that models two-phase flows with mass transfer coupled to the process of chemotaxis. These thermodynamically consistent models can be seen as the natural Navier--Stokes analogues…

偏微分方程分析 · 数学 2023-07-28 Kei Fong Lam , Hao Wu

Mathematical models that describe the tumor growth process have been formulated by several authors in order to understand how cancer develops and to develop new treatment approaches. In this study, it is aimed to investigate the long-time…

偏微分方程分析 · 数学 2020-08-26 Harald Garcke , Sema Yayla

In this paper, we introduce a model describing the dynamic of vesicle membranes within an incompressible viscous fluid in $3D$ domains. The system consists of the Navier-Stokes equations, with an extra stress tensor depending on the…

偏微分方程分析 · 数学 2017-10-10 Blanca Climent-Ezquerra , Francisco Guillén-González

We study the coupling of a viscoelastic deformation governed by a Kelvin-Voigt model at equilibrium, based on the concept of second-grade nonsimple materials, with a plastic deformation due to volumetric swelling, described via a…

偏微分方程分析 · 数学 2024-09-12 Thomas Eiter , Leonie Schmeller

We study a non-local variant of a diffuse interface model proposed by Hawkins--Darrud et al. (2012) for tumour growth in the presence of a chemical species acting as nutrient. The system consists of a Cahn--Hilliard equation coupled to a…

偏微分方程分析 · 数学 2017-03-13 Sergio Frigeri , Kei Fong Lam , Elisabetta Rocca

We study a stochastic phase-field model for tumor growth dynamics coupling a stochastic Cahn-Hilliard equation for the tumor phase parameter with a stochastic reaction-diffusion equation governing the nutrient proportion. We prove strong…

偏微分方程分析 · 数学 2021-01-19 Carlo Orrieri , Elisabetta Rocca , Luca Scarpa

We investigate avascular tumour growth as a two-phase process consisting of cells and liquid. Based on the one-dimensional continuum moving-boundary model formulated by (Byrne, King, McElwain, Preziosi, Applied Mathematics Letters, 2003,…

偏微分方程分析 · 数学 2020-06-24 Andrea Genovese de Oliveira , John R. King

In this paper, we study a nonlinearly coupled initial-boundary value problem describing the evolution of brain tumor growth including lactate metabolism. In our modeling approach, we also take into account the viscoelastic properties of the…

偏微分方程分析 · 数学 2025-02-05 Giulia Cavalleri , Pierluigi Colli , Alain Miranville , Elisabetta Rocca