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Recently we considered a stochastic discrete model which describes fronts of cells invading a wound \cite{KSS}. In the model cells can move, proliferate, and experience cell-cell adhesion. In this work we focus on a continuum description of…

统计力学 · 物理学 2009-11-13 Evgeniy Khain , Leonard M. Sander

We extend previous weak well-posedness results obtained in Frigeri et al. (2017) concerning a non-local variant of a diffuse interface tumor model proposed by Hawkins-Daarud et al. (2012). The model consists of a non-local Cahn--Hilliard…

偏微分方程分析 · 数学 2021-01-20 S. Frigeri , K. F. Lam , A. Signori

A mathematical analysis of local and nonlocal phase-field models of tumor growth is presented that includes time-dependent Darcy-Forchheimer-Brinkman models of convective velocity fields and models of long-range cell interactions. A…

偏微分方程分析 · 数学 2020-02-20 Marvin Fritz , Ernesto A. B. F. Lima , J. Tinsley Oden , Barbara Wohlmuth

We study a phase field model proposed recently in the context of tumour growth. The model couples a Cahn-Hilliard-Brinkman (CHB) system with a elliptic reaction-diffusion equation for a nutrient. The fluid velocity, governed by the Brinkman…

偏微分方程分析 · 数学 2019-09-06 Matthias Ebenbeck , Kei Fong Lam

Models of tumor growth, now commonly used, present several levels of complexity, both in terms of the biomedical ingredients and the mathematical description. The simplest ones contain competition for space using purely fluid mechanical…

偏微分方程分析 · 数学 2015-06-12 Benoît Perthame , Fernando Quirós , Juan Luis Vázquez

We prove existence of weak solutions to a diffuse interface model describing the flow of a fluid through a deformable porous medium consisting of two phases. The system non-linearly couples Biot's equations for poroelasticity, including…

偏微分方程分析 · 数学 2024-08-27 Helmut Abels , Harald Garcke , Jonas Haselböck

We consider the problem of the long time dynamics for a diffuse interface model for tumor growth. The model describes the growth of a tumor surrounded by host tissues in the presence of a nutrient and consists in a Cahn-Hilliard-type…

偏微分方程分析 · 数学 2018-10-30 Alain Miranville , Elisabetta Rocca , Giulio Schimperna

The mathematical modeling of tumor growth leads to singular stiff pressure law limits for porous medium equations with a source term. Such asymptotic problems give rise to free boundaries, which, in the absence of active motion, are…

偏微分方程分析 · 数学 2015-07-06 Inwon C. Kim , Benoit Perthame , Panagiotis E. Souganidis

Biomembranes and vesicles consisting of multiple phases can attain a multitude of shapes, undergoing complex shape transitions. We study a Cahn--Hilliard model on an evolving hypersurface coupled to Navier--Stokes equations on the surface…

数值分析 · 数学 2019-11-01 John W. Barrett , Harald Garcke , Robert Nürnberg

We prove the existence of a unique large-data global-in-time weak solution to a class of models of the form $\mathbf{u}_{tt} = \mathrm{div}(\mathbb{T}) + \mathbf{f}$ for viscoelastic bodies exhibiting strain-limiting behaviour, where the…

偏微分方程分析 · 数学 2020-11-17 Miroslav Bulíček , Victoria Patel , Yasemin Şengül , Endre Süli

This paper investigates an optimal control problem associated with a two-dimensional multi-species Cahn-Hilliard-Keller-Segel tumor growth model, which incorporates complex biological processes such as species diffusion, chemotaxis,…

偏微分方程分析 · 数学 2024-07-26 Pierluigi Colli , Gianni Gilardi , Andrea Signori , Jürgen Sprekels

We consider a mathematical model coupling the Cahn-Hilliard system for phase separation with an additional equation describing the diffusion process of a chemical quantity whose concentration influences the physical process. The main…

偏微分方程分析 · 数学 2025-11-17 Giulio Schimperna , Antonio Segatti

We investigate the dynamics of a nonlinear model for tumor growth within a cellular medium. In this setting the "tumor" is viewed as a multiphase flow consisting of cancerous cells in either proliferating phase or quiescent phase and a…

偏微分方程分析 · 数学 2015-03-31 Donatella Donatelli , Konstantina Trivisa

We consider a mathematical model for the evolutionary dynamics of tumour cells in vascularised tumours under chemotherapy. The model comprises a system of coupled partial integro-differential equations for the phenotypic distribution of…

组织与器官 · 定量生物学 2020-06-02 Chiara Villa , Mark A. J. Chaplain , Tommaso Lorenzi

This paper deals with a general system of equations and conditions arising from a mathematical model of prostate cancer growth with chemotherapy and antiangiogenic therapy that has been recently introduced and analyzed (see [P. Colli et…

偏微分方程分析 · 数学 2021-04-02 Pierluigi Colli , Gianni Gilardi , Jürgen Sprekels

In this paper, we study a distributed optimal control problem for a diffuse interface model for tumor growth. The model consists of a Cahn-Hilliard type equation for the phase field variable coupled to a reaction diffusion equation for the…

最优化与控制 · 数学 2021-10-12 Matthias Ebenbeck , Patrik Knopf

Recently, Jiang--Jiang (J. Differential Equations 282, 2021) showed the existence of unique strong solutions in spatial periodic domain (denoted by $\mathbb{T}^3$), whenever the elasticity coefficient is larger than the initial velocity…

偏微分方程分析 · 数学 2024-11-27 Shengbin Fu , Wenting Huang , Fei Jiang

This paper concerns a distributed optimal control problem for a tumor growth model of Cahn-Hilliard type including chemotaxis with possibly singular potentials, where the control and state variables are nonlinearly coupled. First, we…

最优化与控制 · 数学 2023-06-06 Pierluigi Colli , Andrea Signori , Jürgen Sprekels

We consider a local Cahn-Hilliard-type model for tumor growth as well as a nonlocal model where, compared to the local system, the Laplacian in the equation for the chemical potential is replaced by a nonlocal operator. The latter is…

偏微分方程分析 · 数学 2024-02-22 Christoph Hurm , Maximilian Moser

We study one-dimensional viscoelastic phase transitions modeled by a Ginzburg--Landau energy with a non-convex cubic stress-strain law. Extending the isothermal model, we couple the momentum equation to a heat equation for the temperature…

偏微分方程分析 · 数学 2026-05-05 M. Affouf