相关论文: A HELE-SHAW problem for tumor growth

In this paper, we study a distributed optimal control problem for a diffuse interface model for tumor growth. The model consists of a Cahn-Hilliard type equation for the phase field variable coupled to a reaction diffusion equation for the…

The goal of cancer genome sequencing projects is to determine the genetic alterations that cause common cancers. Many malignancies arise during the clonal expansion of a benign tumor which motivates the study of recurrent selective sweeps…

We analyze the contact Hele-Shaw problem with zero surface tension of a free boundary in a thin domain $\Omega^{\varepsilon}(t).$ Under suitable conditions on the given data, the one-valued local classical solvability of the problem for…

In this paper we study asymptotic behavior of solutions for a free boundary problem modeling the growth of tumors containing two species of cells: proliferating cells and quiescent cells. This tumor model was proposed by Pettet et al in…

In this work, we show how to obtain a free boundary problem as the limit of a fully non linear elliptic system of equations that models population segregation (Gause-Lotka-Volterra type). We study the regularity of the solutions. In…

In this work, we consider a diffuse interface model for tumour growth in the presence of a nutrient which is consumed by the tumour. The system of equations consists of a Cahn--Hilliard equation with source terms for the tumour cells and a…

We study the optimal control problem of a free boundary PDE model describing the growth of multilayered tumor tissue in vitro. We seek the optimal amount of tumor growth inhibitor that simultaneously minimizes the thickness of the tumor…

One of the most popular models for quantitatively understanding the emergence of drug resistance both in bacterial colonies and in malignant tumors was introduced long ago by Luria and Delbr\"uck. Here, individual resistant mutants emerge…

This paper treats a distributed optimal control problem for a tumor growth model of viscous Cahn--Hilliard type. The evolution of the tumor fraction is governed by a thermodynamic force induced by a double-well potential of logarithmic…

We study a model introduced by Perthame and Vauchelet that describes the growth of a tumor governed by Brinkman's Law, which takes into account friction between the tumor cells. We adopt the viscosity solution approach to establish an…

In this paper, we consider a model with tumor microenvironment involving nutrient density, extracellular matrix and matrix-degrading enzymes, which satisfy a coupled system of PDEs with a free boundary. For this coupled parabolic-hyperbolic…

We consider a family of Leray-$\alpha$ models with periodic boundary conditions in three space dimensions. Such models are a regularization, with respect to a parameter $\theta$, of the Navier-Stokes equations. In particular, they share…

We study the existence of weak solutions to a Cahn--Hilliard--Darcy system coupled with a convection-reaction-diffusion equation through the fluxes, through the source terms and in Darcy's law. The system of equations arises from a mixture…

We present a phase-space analysis of a mathematical model of tumor growth with an immune responses. We consider mathematical analysis of the model equations with multipoint initial condition regarding to dissipativity, boundedness of…

In this work, we investigate a distributed optimal control problem for an extended phase field system of Cahn--Hilliard type which physical context is that of tumor growth dynamics. In a previous contribution, the author has already studied…

In this paper, we study a tumor growth model with nutrients. The contact inhibition for the tumor cells, presented in the model, results in the evolution of a congested tumor patch. We study the regularity of the tumor patch as the…

We consider a diffuse interface model for tumour growth consisting of a Cahn--Hilliard equation with source terms coupled to a reaction-diffusion equation. The coupled system of partial differential equations models a tumour growing in the…

We derive a Cahn-Hilliard-Darcy model to describe multiphase tumour growth taking interactions with multiple chemical species into account as well as the simultaneous occurrence of proliferating, quiescent and necrotic regions. Via a…

We develop a numerical method for solving a free boundary problem which describes shape relaxation, by surface tension, of a long and thin bubble of an inviscid fluid trapped inside a viscous fluid in a Hele-Shaw cell. The method of…

The well known nonlinear model for describing the solid tumour growth [Byrne HM., et al. Appl Math Letters 2003;16:567-74] is under study using an approach based on Lie symmetries. It is shown that the model in the two-dimensional (in…