相关论文: A HELE-SHAW problem for tumor growth
Unstable dynamics characterizes the evolution of most solid tumors. Because of an increased failure of maintaining genome integrity, a cumulative increase in the levels of gene mutation and loss is observed. Previous work suggests that…
In this paper, we study a phase-space analysis of a mathematical model of tumor growth with an immune response. Mathematical analysis of the model equations with multipoint initial condition, regarding to dissipativity, boundedness of…
Understanding the untreated tumor growth kinetics and its intrinsic findings is interesting and intriguing. The aim of this study is to propose an approximate analytical expression that allows to simulate changes in surface charge density…
We consider a one-dimensional version of a model obtained in [C. Engwer, A. Hunt, and C. Surulescu: Effective equations for anisotropic glioma spread with proliferation: a multiscale approach and comparisons with previous settings, IMA J.…
Most cancers in humans are large, measuring centimeters in diameter, composed of many billions of cells. An equivalent mass of normal cells would be highly heterogeneous as a result of the mutations that occur during each cell division.…
We discuss a lubrication approximation model of the interface between two immiscible fluids in a Hele-Shaw cell, derived in \cite{CDGKSZ93} and widely studied since. The model consists of a single one dimensional evolution equation for the…
Models of tissue growth are now well established, in particular in relation to their applications to cancer. They describe the dynamics of cells subject to motion resulting from a pressure gradient generated by the death and birth of cells,…
In this work, we present a phase-field model for tumour growth, where a diffuse interface separates a tumour from the surrounding host tissue. In our model, we consider transport processes by an internal, non-solenoidal velocity field. We…
We present a two-dimensional continuum model of tumor growth, which treats the tissue as a composition of six distinct fluid phases; their dynamics are governed by the equations of mass and momentum conservation. Our model divides the…
This paper deals with a free boundary problem of the Lotka-Volterra type prey-predator model with variable intrinsic growth rate for predator over a one dimensional habitat, in which the free boundary represents the spreading front and is…
We show existence and uniqueness of very weak solutions of the Cauchy problem for the porous medium equation on Cartan-Hadamard manifolds satisfying suitable lower bounds on Ricci curvature, with initial data that can grow at infinity at a…
A mathematical model describing motion of an inhomogeneous incompressible fluid in a Hele-Shaw cell is considered. Linear stability analysis of shear flow class is provided. The role of inertia, linear friction and impermeable boundaries in…
We consider the homogenization of the Hele-Shaw problem in periodic media that are inhomogeneous both in space and time. After extending the theory of viscosity solutions into this context, we show that the solutions of the inhomogeneous…
In this paper we propose an ecological resilience point of view on cancer. This view is based on the analysis of a simple ODE model for the interactions between cancer and normal cells. The model presents two regimes for tumor growth. In…
This paper is concerned with a nonlinear free boundary problem modeling the growth of spherically symmetric tumors with angiogenesis, set with a Robin boundary condition. In which, both nonnecrotic tumors and necrotic tumors are taken into…
This paper studies the following system of differential equations modeling tumor angiogenesis in a bounded smooth domain $\Omega \subset \mathbb{R}^N$ ($N=1,2$): $$\label{0} \left\{\begin{array}{ll} p_t=\Delta p-\nabla\cdotp…
In this paper, we study an optimal control problem for a nonlinear system of reaction-diffusion equations that constitutes a simplified and relaxed version of a thermodynamically consistent phase field model for tumor growth originally…
An optimal control problem for a model of tumor growth is studied. In a given subdomain, it is required to minimize the density of tumor cells, while the drug concentration in tissue is limited by given minimal and maximal values. Based on…
Tumor growth has long been a target of investigation within the context of mathematical and computer modelling. The objective of this study is to propose and analyze a two-dimensional probabilistic cellular automata model to describe…
We complete previous results about the incompressible limit of both the $n$-dimensional $(n\geq3)$ compressible Patlak-Keller-Segel (PKS) model and its stationary state. As in previous works, in this limit, we derive the weak form of a…