相关论文: A HELE-SHAW problem for tumor growth
We consider a non-local tumour growth model of phase-field type, describing the evolution of tumour cells through proliferation in presence of a nutrient. The model consists of a coupled system, incorporating a non-local Cahn-Hilliard…
In this paper we study a model describing the growth of necrotic tumors in different regimes of vascularisation. The tumor consists of a necrotic core of death cells and a surrounding nonnecrotic shell. The corresponding mathematical…
Phase field models recently gained a lot of interest in the context of tumour growth models. Typically Darcy-type flow models are coupled to Cahn-Hilliard equations. However, often Stokes or Brinkman flows are more appropriate flow models.…
We study a singular limit of the classical parabolic-elliptic Patlak-Keller-Segel (PKS) model for chemotaxis with non linear diffusion. The main result is the $\Gamma$ convergence of the corresponding energy functional toward the perimeter…
We investigate the long-time dynamics and optimal control problem of a diffuse interface model that describes the growth of a tumor in presence of a nutrient and surrounded by host tissues. The state system consists of a Cahn-Hilliard type…
In this paper, we studied phase-space analysis of a certain mathematical model of tumor growth with an immune responses and chemotherapy therapy. Mathematical modelling of this process is viewed as a potentially powerful tool in the…
We consider the evolution of two incompressible, immiscible fluids with different densities in porous media, known as the Muskat problem [21], which in two dimensions is analogous to the Hele-Shaw cell [26]. We establish, for a class of…
We consider a model of congestion dynamics with chemotaxis: The density of cells follows a chemical signal it generates, while subject to an incompressibility constraint. The incompressibility constraint results in the formation of patches,…
We consider an optimal control problem for a diffuse interface model of tumor growth. The state equations couples a Cahn-Hilliard equation and a reaction-diffusion equation, which models the growth of a tumor in the presence of a nutrient…
Tumor growth has a number of features in common with a physical process known as molecular beam epitaxy. Both growth processes are characterized by the constraint of growth development to the body border, and surface diffusion of…
In this paper we study a mathematical model for the growth of nonnecrotic solid tumor. The tumor is assumed to be radially symmetric and its radius R(t) is an unknown function of time t as tumor growth, and the model is in the form of a…
In this paper, we present a rigorous mathematical analysis of a free boundary problem modeling the growth of a vascular solid tumor with a necrotic core. If the vascular system supplies the nutrient concentration $\sigma$ to the tumor at a…
We investigate a Hele-Shaw type free boundary problem in one spatial dimension, where heterogeneities appear both on the free boundary and within the interior of the positivity set. Our contributions are twofold. First, we establish…
We prove existence of weak solutions and weak-strong uniqueness for a mathematical model which couples the evolution of a phase-parameter $\varphi$ satisfying a Cahn-Hilliard type relation with the one of an additional variable $\sigma$…
This paper investigates an optimal control problem associated with a two-dimensional multi-species Cahn-Hilliard-Keller-Segel tumor growth model, which incorporates complex biological processes such as species diffusion, chemotaxis,…
We consider a macroscopic model for the growth of living tissues incorporating pressure-driven dispersal and pressure-modulated proliferation. Assuming a power-law relation between the mechanical pressure and the cell density, the model can…
We consider the problem of the long time dynamics for a diffuse interface model for tumor growth. The model describes the growth of a tumor surrounded by host tissues in the presence of a nutrient and consists in a Cahn-Hilliard-type…
In this paper we study the regularity property of Hele-Shaw flow, where source and drift are present in the evolution. More specifically we consider H\"{o}lder continuous source and Lipschitz continuous drift. We show that if the free…
We study the spatial evolutionary dynamics of solid tumors as they obtain additional driver mutations. We start with a cancer clone that expands uniformly in three dimensions giving rise to a spherical shape. We assume that cell division…
Tumor cells develop different features to adapt to environmental conditions. A prominent example is the ability of tumor cells to switch between migratory and proliferative phenotypes, a phenomenon known as go-or-grow mechanism. It is…