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We study a diffuse interface model describing the evolution of the flow of a binary fluid in a Hele-Shaw cell. The model consists of a Cahn-Hilliard-Darcy (CHD) type system with transport and mass source. A relevant physical application is…

偏微分方程分析 · 数学 2020-09-29 Andrea Giorgini , Kei Fong Lam , Elisabetta Rocca , Giulio Schimperna

We study the existence of weak solutions to a Cahn--Hilliard--Darcy system coupled with a convection-reaction-diffusion equation through the fluxes, through the source terms and in Darcy's law. The system of equations arises from a mixture…

偏微分方程分析 · 数学 2016-10-25 Harald Garcke , Kei Fong Lam

We study an evolutionary system of Cahn-Hilliard-Darcy type including mass source and transport effects. The system may arise in a number of physical situations related to phase separation phenomena with convection, with the main and most…

偏微分方程分析 · 数学 2022-02-24 Giulio Schimperna

We study a Cahn-Hilliard-Darcy system with mass sources, which can be considered as a basic, though simplified, diffuse interface model for the evolution of tumor growth. This system is equipped with an impermeability condition for the…

最优化与控制 · 数学 2024-08-20 Marco Abatangelo , Cecilia Cavaterra , Maurizio Grasselli , Hao Wu

We study the existence of weak solutions to a mixture model for tumour growth that consists of a Cahn--Hilliard--Darcy system coupled with an elliptic reaction-diffusion equation. The Darcy law gives rise to an elliptic equation for the…

偏微分方程分析 · 数学 2018-03-26 Harald Garcke , Kei Fong Lam

We consider a diffuse interface model of tumor growth proposed by A.~Hawkins-Daruud et al. This model consists of the Cahn-Hilliard equation for the tumor cell fraction $\varphi$ nonlinearly coupled with a reaction-diffusion equation for…

偏微分方程分析 · 数学 2014-12-05 Sergio Frigeri , Maurizio Grasselli , Elisabetta Rocca

We consider a diffuse interface model for tumour growth consisting of a Cahn--Hilliard equation with source terms coupled to a reaction-diffusion equation. The coupled system of partial differential equations models a tumour growing in the…

偏微分方程分析 · 数学 2016-05-26 Harald Garcke , Kei Fong Lam

We consider the problem of the long time dynamics for a diffuse interface model for tumor growth. The model describes the growth of a tumor surrounded by host tissues in the presence of a nutrient and consists in a Cahn-Hilliard-type…

偏微分方程分析 · 数学 2018-10-30 Alain Miranville , Elisabetta Rocca , Giulio Schimperna

In this paper, we study an optimal control problem for a two-dimensional Cahn-Hilliard-Darcy system with mass sources that arises in the modeling of tumor growth. The aim is to monitor the tumor fraction in a finite time interval in such a…

偏微分方程分析 · 数学 2023-07-28 Juergen Sprekels , Hao Wu

We consider a model describing the evolution of a tumor inside a host tissue in terms of the parameters $\varphi_p$, $\varphi_d$ (proliferating and dead cells, respectively), $u$ (cell velocity) and $n$ (nutrient concentration). The…

偏微分方程分析 · 数学 2017-09-06 Sergio Frigeri , Kei Fong Lam , Elisabetta Rocca , Giulio Schimperna

In this work, we study a model consisting of a Cahn-Hilliard-type equation for the concentration of tumour cells coupled to a reaction-diffusion type equation for the nutrient density and a Brinkman-type equation for the velocity. We equip…

偏微分方程分析 · 数学 2018-11-19 Matthias Ebenbeck , Harald Garcke

In this work, we develop a structure-preserving numerical scheme for a Cahn-Hilliard-Darcy model that describes tumor growth in a fluid-saturated porous medium. First, we derive a physically consistent model from the general framework…

We study an initial-boundary value problem for the incompressible Navier-Stokes-Cahn-Hilliard system with non-constant density proposed by Abels, Garcke and Gr\"{u}n in 2012. This model arises in the diffuse interface theory for binary…

偏微分方程分析 · 数学 2023-02-21 Helmut Abels , Harald Garcke , Andrea Giorgini

We investigate a multiphase Cahn-Hilliard model for tumor growth with general source terms. The multiphase approach allows us to consider multiple cell types and multiple chemical species (oxygen and/or nutrients) that are consumed by the…

偏微分方程分析 · 数学 2022-06-22 Patrik Knopf , Andrea Signori

We consider a diffuse interface model for tumor growth consisting of a Cahn--Hilliard equation with source terms coupled to a reaction-diffusion equation, which models a tumor growing in the presence of a nutrient species and surrounded by…

偏微分方程分析 · 数学 2017-05-04 Harald Garcke , Kei Fong Lam

We study an initial-boundary value problem (IBVP) for a coupled Cahn-Hilliard-Hele-Shaw system that models tumor growth. For large initial data with finite energy, we prove global (local resp.) existence, uniqueness, higher order spatial…

偏微分方程分析 · 数学 2012-05-31 John Lowengrub , Edriss S. Titi , Kun Zhao

In this paper we study a non-local Cahn-Hilliard equation with singular single-well potential and degenerate mobility. This results as a particular case of a more general model derived for a binary, saturated, closed and incompressible…

偏微分方程分析 · 数学 2023-06-29 Abramo Agosti , Elisabetta Rocca , Luca Scarpa

In this work, we consider a diffuse interface model for tumour growth in the presence of a nutrient which is consumed by the tumour. The system of equations consists of a Cahn--Hilliard equation with source terms for the tumour cells and a…

数值分析 · 数学 2022-05-09 Harald Garcke , Dennis Trautwein

We consider the classical initial and boundary value problem for the Cahn--Hilliard equation with non-degenerate mobility and singular (e.g., logarithmic) potential. We prove that any weak solution converges to a single equilibrium using…

偏微分方程分析 · 数学 2026-02-06 Maurizio Grasselli , Andrea Poiatti

In this manuscript, we study a nonlinear model of tumor growth, described by a coupled hyperbolic-elliptic system of partial differential equations. In this model, the compressible flow of tumor cells is modeled by a transport equation for…

偏微分方程分析 · 数学 2025-08-27 Jeffrey Kuan , Konstantina Trivisa
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