相关论文: Linearized stability for a multi-dimensional free …
This paper concerns a free boundary problem modeling tumor growth with angiogenesis and two time delays. The two delays represent the time taken for cells to undergo mitosis and modify the rate of cell loss because of apoptosis,…
Motivated by the incompressible limit of a cell density model, we propose a free boundary tumor growth model where the pressure satisfies an obstacle problem on an evolving domain $\Omega(t)$, and the coincidence set $\Lambda(t)$ captures…
We consider a diffuse interface model for tumor growth recently proposed in [Y. Chen, S.M. Wise, V.B. Shenoy, J.S. Lowengrub, A stable scheme for a nonlinear, multiphase tumor growth model with an elastic membrane, Int. J. Numer. Methods…
Many mathematical models in different disciplines involve the formulation of free boundary problems, where the domain boundaries are not predefined. These models present unique challenges, notably the nonlinear coupling between the solution…
The mathematical modeling of tumor growth leads to singular stiff pressure law limits for porous medium equations with a source term. Such asymptotic problems give rise to free boundaries, which, in the absence of active motion, are…
This paper provides a unified mathematical analysis of a family of non-local diffuse interface models for tumor growth describing evolutions driven by long-range interactions. These integro-partial differential equations model cell-to-cell…
If a differential equation in a Banach manifold is invariant or quasi-invariant under the action of one or more Lie groups, then its stationary points cannot be isolated, so that classical linearized stability theorem does not apply to it.…
We develop an existence and regularity theory for solutions to a geometric free boundary problem motivated by models of tumor growth. In this setting, the tumor invades an accessible region $D$, its motion is directed along a constant…
We study the optimal control problem of a free boundary PDE model describing the growth of multilayered tumor tissue in vitro. We seek the optimal amount of tumor growth inhibitor that simultaneously minimizes the thickness of the tumor…
We investigate the dynamics of a nonlinear system modeling tumor growth with drug application. The tumor is viewed as a mixture consisting of proliferating, quiescent and dead cells as well as a nutrient in the presence of a drug. The…
We investigate the dynamics of a nonlinear model for tumor growth within a cellular medium. In this setting the "tumor" is viewed as a multiphase flow consisting of cancerous cells in either proliferating phase or quiescent phase and a…
We consider a free boundary tumor model under the presence of angiogenesis and time delays in the process of proliferation, in which the cell location is incorporated. It is assumed that the tumor attracts blood vessels at a rate…
We consider a biphasic continuum model for avascular tumour growth in two spatial dimensions, in which a cell phase and a fluid phase follow conservation of mass and momentum. A limiting nutrient that follows a diffusion process controls…
In this paper a macroscopic model of tumor cord growth is developed, relying on the mathematical theory of deformable porous media. Tumor is modeled as a saturated mixture of proliferating cells, extracellular fluid and extracellular…
In this paper we study the growth of a tumor colony of multilayer type and focus on how the tumor grows from a near flat (when compared to the length of the tumor as, for instance, in the case of a bone tumor in a femur) initial colony. In…
The amplification of an external signal is a key step in direction sensing of biological cells. We consider a simple model for the response to a time-depending signal, which was previously proposed by the last three authors. The model…
In this paper, we consider a free boundary multi-layer tumor model that incorporates a $T-$periodic provision of external nutrients $\Phi(t)$. The simplified model contains three parameters: the mean of periodic external nutrients…
The problem of the onset and growth of solid tumour in homogeneous tissue is regarded using an approach based on local interaction between the tumoral and the sane tissue cells. The characteristic sizes and growth rates of spherical…
We consider a coupled bulk-surface system of partial differential equations with nonlinear coupling modelling receptor-ligand dynamics. The model arises as a simplification of a mathematical model for the reaction between cell surface…
We consider weak solutions to a problem modeling tumor growth. Under certain conditions on the initial data, solutions can be obtained by passing to the stiff (incompressible) limit in a porous medium type problem with a Lotka-Volterra…