相关论文: Linearized stability for a multi-dimensional free …
We consider a diffuse interface model for tumor growth consisting of a Cahn--Hilliard equation with source terms coupled to a reaction-diffusion equation, which models a tumor growing in the presence of a nutrient species and surrounded by…
We study solutions to a one-phase singular perturbation problem that arises in combustion theory and that formally approximates the classical one-phase free boundary problem. We introduce a natural density condition on the transition layers…
A mutualist model with nonlocal diffusions and a free boundary is first considered. We prove that this problem has a unique solution defined $t\ge0$, and its dynamics are governed by a spreading-vanishing dichotomy. Some criteria for…
In this paper we study a mass-constrained free boundary problem modeling cell polarization, in the regime where the mass is small. In the generic case of a signal with nondegenerate maxima, we prove that the solution converges locally to a…
We formulate a Hele-Shaw type free boundary problem for a tumor growing under the combined effects of pressure forces, cell multiplication and active motion, the latter being the novelty of the present paper. This new ingredient is…
In this paper, we study a tumor growth model where the growth is driven by nutrient availability and the tumor expands according to Darcy's law with a mechanical pressure resulting from the incompressibility of the cells. Our focus is on…
We study a two-dimensional free boundary problem that models motility of eukaryotic cells on substrates. This problem consists of an elliptic equation describing the flow of cytoskeleton gel coupled with a convection-diffusion PDE for the…
We introduce a two-dimensional Keller-Segel type free boundary model for motility of eukaryotic cells on substrates. The key ingredients of this model are the Darcy law for overdamped motion of the cytoskeleton (active) gel and Hele-Shaw…
We introduce a nonlinear and nonlocal model that describes the range expansion of a population resulting from growth and competition for space. This type of phenomenon underlies the expansion of colonies of immotile cells which motivated…
The uncontrolled proliferation of cancer cells and their interaction with healthy tissue poses a major challenge in oncology. This manuscript develops and analyzes mathematical models that describe tumor response to radiotherapy by…
In this paper, we develop a sharp interface tumor growth model in two dimensions to study the effect of both the intratumoral structure using a controlled necrotic core and the extratumoral nutrient supply from vasculature on tumor…
We construct a diffuse-interface model of two-phase solidification that quantitatively reproduces the classic free boundary problem on solid-liquid interfaces in the thin-interface limit. Convergence tests and comparisons with boundary…
We present a two-dimensional continuum model of tumor growth, which treats the tissue as a composition of six distinct fluid phases; their dynamics are governed by the equations of mass and momentum conservation. Our model divides the…
In this paper, we investigate the Rayleigh-Taylor instability problem for two compressible, immiscible, inviscid flows rotating with an constant angular velocity, and evolving with a free interface in the presence of a uniform gravitational…
In this paper, we develop a sharp interface tumor growth model to study the effect of the tumor microenvironment using a complex far-field geometry that mimics a heterogeneous distribution of vasculature. Together with different nutrient…
We consider a class of tumor growth models under the combined effects of density-dependent pressure and cell multiplication, with a free boundary model as its singular limit when the pressure-density relationship becomes highly nonlinear.…
We consider a Hele-Shaw model that describes tumor growth subject to nutrient supply. The model is derived by taking the incompressible limit of porous medium type equations, and the boundary instability of this model was recently studied…
A distributed optimal control problem for a phase field system which physical context is that of tumor growth is discussed. The system we are going to take into account consists of a Cahn-Hilliard equation for the phase variable (relative…
In this paper we study a tumor growth model with nutrients. The model presents dynamic patch solutions due to the contact inhibition among the tumor cells. We show that when the nutrients do not diffuse and the cells do not die, the tumor…
We present a multiphase mathematical model for tumor growth which incorporates the remodeling of the extracellular matrix and describes the formation of fibrotic tissue by tumor cells. We also detail a full qualitative analysis of the…