相关论文: Viscoelastic Cahn--Hilliard models for tumour grow…

We consider very weak solutions of the Cauchy problem for the porous medium equation on Cartan-Hadamard manifolds, that are assumed to satisfy general curvature bounds and to be stochastically complete. We identify a class of initial data…

The Cauchy problem of the compressible Oldroyd-B model without damping mechanism in R^n$ with $n\ge2$ is considered. The lack of dissipation in density and stress tensor in the model is compensated by exploiting an intrinsic structure and…

In this work we study a quasi-static evolution of thermo-visco-elastic model with homogeneous thermal expansion. We assume that material is subject to two kinds of mechanical deformations: elastic and inelastic. Inelastic deformation is…

We investigate the long-time dynamics and optimal control problem of a diffuse interface model that describes the growth of a tumor in presence of a nutrient and surrounded by host tissues. The state system consists of a Cahn-Hilliard type…

In this paper, a distributed optimal control problem is studied for a diffuse interface model of tumor growth which was proposed in [A. Hawkins-Daruud, K.G. van der Zee, J.T. Oden, Numerical simulation of a thermodynamically consistent…

We derive, through the deterministic homogenization theory in thin domains, a new model consisting of Hele-Shaw equation with memory coupled with the convective Cahn-Hilliard equation. The obtained system, which models in particular tumor…

This paper presents a convergence analysis of the evolving surface finite element method (ESFEM) applied to the original Eyles-King-Styles model of tumour growth. The model consists of a Poisson equation in the bulk, a forced mean curvature…

In this work, we study a phase-field model for curvature-driven pattern formation in biomembranes. The model is derived as a gradient flow of an energy functional that approximates the two-phase Canham--Helfrich energy. This leads to a…

It is widely recognized that reciprocal interactions between cells and their microenvironment, via mechanical forces and biochemical signaling pathways, regulate cell behaviors during normal development, homeostasis and disease progression…

In this paper we prove the existence of solutions for a class of viscoelastic dynamic systems on time--dependent cracked domains, with possibly degenerate viscosity coefficients. Under stronger regularity assumptions we also show a…

Visco-energetic solutions have been recently advanced as a new solution concept for rate-independent systems, alternative to energetic solutions/quasistatic evolutions and balanced viscosity solutions. In the spirit of this novel concept,…

In this paper we present a method for estimating unknown parameters that appear on an avascular, spheric tumour growth model. The model for the tumour is based on nutrient driven growth of a continuum of live cells, whose birth and death…

We consider the inverse problem of identifying parameters in a variant of the diffuse interface model for tumour growth model proposed by Garcke, Lam, Sitka and Styles (Math. Models Methods Appl. Sci. 2016). The model contains three…

This paper treats a distributed optimal control problem for a tumor growth model of viscous Cahn--Hilliard type. The evolution of the tumor fraction is governed by a thermodynamic force induced by a double-well potential of logarithmic…

In this survey article, a variety of systems modeling tumor growth are discussed. In accordance with the hallmarks of cancer, the described models incorporate the primary characteristics of cancer evolution. Specifically, we focus on…

In this paper, a two-dimensional model for the growth of multi-layer tumors is presented. The model consists of a free boundary problem for the tumor cell membrane and the tumor is supposed to grow or shrink due to cell proliferation or…

The work presents a study of the non-linear mathematical model of tumor growth, proposed by Kolev and Zubik-Kowal (2011). The model is described by a system composed of four partial differential equations that represent the evolution of the…

A systematic understanding of the evolution and growth dynamics of invasive solid tumors in response to different chemotherapy strategies is crucial for the development of individually optimized oncotherapy. Here, we develop a hybrid…

Phase-field models of tumour growth have proved useful as theoretical tools to investigate cancer invasion. A key implicit assumption underlying mathematical models of this type which have so far been proposed, though, is that cells in the…

Clinically, palpation is one of the important diagnostic methods to assess tumor malignancy. In laboratory research, it is well accepted that the bulk stiffness of the tumor and the surrounding tissue is closely correlated with the…