相关论文: Free boundary problems for Tumor Growth: a Viscosi…
We study nonlinear diffusion problems of the form $u_t=u_{xx}+f(u)$ with free boundaries. Such problems may be used to describe the spreading of a biological or chemical species, with the free boundary representing the expanding front. For…
We consider a free boundary problem for a system of PDEs, modeling the growth of a biological tissue. A morphogen, controlling volume growth, is produced by specific cells and then diffused and absorbed throughout the domain. The geometric…
Free boundaries of biofilms advancing on surfaces evolve according to conservation laws coupled with systems of partial differential equations for velocities, pressures and chemicals affecting cell behavior. Thin film approximations lead to…
Spiral waves are a ubiquitous feature of the nonequilibrium dynamics of a great variety of excitable systems. In the limit of a large separation in timescale between fast excitation and slow recovery, one can reduce the spiral problem to…
In this paper, we study the consumption-chemotaxis-Stokes model with porous medium slow diffusion in a three dimensional bounded domain with zero-flux boundary conditions and no-slip boundary condition. In recent ten years, many efforts…
In this paper, we study a nonlinearly coupled initial-boundary value problem describing the evolution of brain tumor growth including lactate metabolism. In our modeling approach, we also take into account the viscoelastic properties of the…
We introduce a new phase field model for tumour growth where viscoelastic effects are taken into account. The model is derived from basic thermodynamical principles and consists of a convected Cahn--Hilliard equation with source terms for…
In this work, we analyze a diffuse-interface model for tumor growth, subject to multiplicative white noises, posed on a bounded domain $\mathcal{O} \subset \mathbb{R}^d$, $d=2,3$. The model couples a stochastic incompressible convective…
In this paper we address some modelling issues related to biological growth. Our treatment is based on a recently-proposed, general formulation for growth within the context of Mixture Theory (Journal of the Mechanics and Physics of Solids,…
A model of unsteady filtration (seepage) in a porous medium with capillary retention is considered. It leads to a free boundary problem for a generalized porous medium equation where the location of the boundary of the water mound is…
In this work, we present a coupled 3D-1D model of solid tumor growth within a dynamically changing vascular network to facilitate realistic simulations of angiogenesis. Additionally, the model includes erosion of the extracellular matrix,…
We study the modeling of a compressible two-phase flow in a porous medium. The governing free boundary problem is known as the Verigin problem with phase transition. We introduce a novel variational framework to construct weak solutions.…
The paper deals with a phase field system of Cahn-Hilliard type. For positive viscosity coefficients, the authors prove an existence and uniqueness result and study the long time behavior of the solution by assuming the nonlinearities to be…
The long time behaviour of solutions to stochastic porous media equations on smooth bounded domains with Dirichlet boundary data is studied. Based on weighted $L^{1}$-estimates the existence and uniqueness of invariant measures with optimal…
We study the distributions of channel openings, local fluxes, and velocities in a two-dimensional random medium of non-overlapping disks. We present theoretical arguments supported by numerical data of high precision and find scaling laws…
We introduce here a new diffuse interface thermodynamically consistent non-isothermal model for tumor growth in presence of a nutrient in a domain $\Omega \subset \mathbb{R}^3$. In particular our system describes the growth of a tumor…
We study expansions near the boundary of solutions to the Dirichlet problem for the constant mean curvature equation in the hyperbolic space. With a characterization of remainders of the expansion by multiple integrals, we establish optimal…
In this paper, we consider a model with tumor microenvironment involving nutrient density, extracellular matrix and matrix-degrading enzymes, which satisfy a coupled system of PDEs with a free boundary. For this coupled parabolic-hyperbolic…
This paper is concerned with the free boundary value problem for multi-dimensional Navier-Stokes equations with density-dependent viscosity where the flow density vanishes continuously across the free boundary. A local (in time) existence…
Solid tumours have the ability to assemble their own vascular network for optimizing their access to the vital nutrients. These new capillaries are morphologically different from normal physiological vessels. In particular, they have a much…