相关论文: Efficient stochastic asymptotic-preserving scheme …
We consider a class of tumor growth models under the combined effects of density-dependent pressure and cell multiplication, with a free boundary model as its singular limit when the pressure-density relationship becomes highly nonlinear.…
We study an optimal control problem for a stochastic model of tumour growth with drug application. This model consists of three stochastic hyperbolic equations describing the evolution of tumour cells. It also includes two stochastic…
In this paper, we develop a sharp interface tumor growth model in two dimensions to study the effect of both the intratumoral structure using a controlled necrotic core and the extratumoral nutrient supply from vasculature on tumor…
This study is a first step towards using data-informed differential models to predict and control the dynamics of cancer-on-chip experiments. We consider a conceptualized one-dimensional device, containing a cancer and a population of white…
The design and analysis of a unified asymptotic preserving (AP) and well-balanced scheme for the Euler Equations with gravitational and frictional source terms is presented in this paper. The asymptotic behaviour of the Euler system in the…
We introduce here a new diffuse interface thermodynamically consistent non-isothermal model for tumor growth in presence of a nutrient in a domain $\Omega \subset \mathbb{R}^3$. In particular our system describes the growth of a tumor…
This paper treats a distributed optimal control problem for a tumor growth model of Cahn-Hilliard type including chemotaxis. The evolution of the tumor fraction is governed by a variational inequality corresponding to a double obstacle…
We consider a particular phase field system which physical context is that of tumor growth dynamics. The model we deal with consists of a Cahn-Hilliard type equation governing the evolution of the phase variable which takes into account the…
Models of tumor growth, now commonly used, present several levels of complexity, both in terms of the biomedical ingredients and the mathematical description. The simplest ones contain competition for space using purely fluid mechanical…
We develop a linear fully discrete structure-preserving finite element method for a diffuse-interface model of tumour growth. The system couples a Cahn--Hilliard type equation with a nonlinear reaction-diffusion equation for nutrient…
The concern of the present work is the introduction of a very efficient Asymptotic Preserving scheme for the resolution of highly anisotropic diffusion equations. The characteristic features of this scheme are the uniform convergence with…
In this paper, a new asymptotic preserving (AP) scheme is proposed for the anisotropic elliptic equations. Different from previous AP schemes, the actual one is based on first-order system least-squares for second-order partial differential…
We consider a class of biologically-motivated stochastic processes in which a unicellular organism divides its resources (volume or damaged proteins, in particular) symmetrically or asymmetrically between its progeny. Assuming the final…
A recent conceptual model of tumor-driven angiogenesis including branching, elongation, and anastomosis of blood vessels captures some of the intrinsic multiscale structures of this complex system, yet allowing to extract a deterministic…
This paper is devoted to the construction of structure preserving stochastic Galerkin schemes for Fokker-Planck type equations with uncertainties and interacting with an external distribution, that we refer to as a background distribution.…
In this paper, we develop a family of high order asymptotic preserving schemes for some discrete-velocity kinetic equations under a diffusive scaling, that in the asymptotic limit lead to macroscopic models such as the heat equation, the…
We propose a new type of diffuse interface model describing the evolution of a tumor mass under the effects of a chemical substance (e.g., a nutrient or a drug). The process is described by utilizing the variables $\varphi$, an order…
We study a spatially inhomogeneous model of cancer growth based on Michaelis--Menten kinetics, subjected to additive Gaussian noise and multiplicative dichotomous noise. In presence of the latter, we can observe a transition between two…
Numerical discretizations of the Generalized Porous Medium Equation (GPME) with discontinuous coefficients are analyzed with respect to the formation of numerical artifacts. In addition to the degeneracy and self-sharpening of the GPME with…
Adoptive Cell Transfer therapy of cancer is currently in full development and mathematical modeling is playing a critical role in this area. We study a stochastic model developed by Baar et al. in 2015 for modeling immunotherapy against…