相关论文: Global Stability of a PDE-ODE model for acid-media…

The acid-mediated tumor invasion hypothesis proposes that altered glucose metabolism exhibited by the vast majority of tumors leads to increased acid (H+ ion) production which subsequently facilitates tumor invasion [1-3]. The…

We present a mathematical analysis of a reaction-diffusion model describing acid-mediated tumor invasion. The model describes the spatial distribution and temporal evolution of tumor cells, normal cells, and excess lactic acid…

The acid-mediation hypothesis, that is, the hypothesis that acid produced by tumours, as a result of aerobic glycolysis, provides a mechanism for invasion, has so far been considered as a relatively closed system. The focus has mainly been…

We propose and study a strongly coupled PDE-ODE system with tissue-dependent degenerate diffusion and haptotaxis that can serve as a model prototype for cancer cell invasion through the extracellular matrix. We prove the global existence of…

We propose and study a strongly coupled PDE-ODE-ODE system modeling cancer cell invasion through a tissue network under the go-or-grow hypothesis asserting that cancer cells can either move or proliferate. Hence our setting features two…

We propose a diffuse interface model to describe tumor as a multicomponent deformable porous medium. We include mechanical effects in the model by coupling the mass balance equations for the tumor species and the nutrient dynamics to a…

In this work we analyse a PDE-ODE problem modelling the evolution of a Glioblastoma, which includes an anisotropic nonlinear diffusion term with a diffusion velocity increasing with respect to vasculature. First, we prove the existence of…

We consider a diffuse interface model for tumor growth recently proposed in [Y. Chen, S.M. Wise, V.B. Shenoy, J.S. Lowengrub, A stable scheme for a nonlinear, multiphase tumor growth model with an elastic membrane, Int. J. Numer. Methods…

In this work, we introduce a variant of the Gatenby-Gawlinski model for acid-mediated tumor invasion in the one-dimensional experimental setting, accounting for heterogeneous diffusion of the lactic acid across the surrounding healthy…

Motivated by an ongoing collaboration with clinical oncologists and pathologists, we develop a hybrid partial differential equation--ordinary differential equation (PDE--ODE) framework that captures (i) competition between susceptible and…

We propose a mathematical model for tumor invasion supported by angiogenesis and interactions with the surrounding tissue. For the model deduction we employ a multiscale approach starting from lower scales and obtaining by an informal…

We consider a Gatenby--Gawlinski-type model of invasive tumors in the presence of an Allee effect. We describe the construction of bistable one-dimensional traveling fronts using singular perturbation techniques in different parameter…

We consider the problem of the long time dynamics for a diffuse interface model for tumor growth. The model describes the growth of a tumor surrounded by host tissues in the presence of a nutrient and consists in a Cahn-Hilliard-type…

In this paper, we consider a model with tumor microenvironment involving nutrient density, extracellular matrix and matrix-degrading enzymes, which satisfy a coupled system of PDEs with a free boundary. For this coupled parabolic-hyperbolic…

We present a mathematical analysis of a mixed ODE-PDE model describing the spatial distribution and temporal evolution of tumor and normal cells within a tissue subject to the effects of a chemotherapeutic drug. The model assumes that the…

In this paper, we propose a new mathematical model nonlinear reaction-diffusion PDE's describing the dynamics of propagation of cancer. Here the mixed problem for the proposed PDE's is investigated and by applying obtained results…

In this paper, we propose a tumor growth model to incorporate and investigate the spatial effects of autophagy. The cells are classified into two phases: normal cells and autophagic cells, whose dynamics are also coupled with the nutrients.…

We consider a phase-field model of prostate cancer growth with chemotherapy and antiangiogenic therapy effects which is introduced in [2]. It is comprised of phase-field equation to describe tumor growth, which is coupled to a…

We investigate a nonlinear parabolic reaction-diffusion equation describing the oxygen concentration in encapsulated pancreatic cells with a general core-shell geometry. This geometry introduces a discontinuous diffusion coefficient as the…

Cancer is a disease that takes millions of lives every year. Then, to propose treatments, avoid recurrence, and improve the patient's life quality, we need to analyze this disease from a biophysical perspective with a solid mathematical…