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In this work, we present a phase-field model for tumour growth, where a diffuse interface separates a tumour from the surrounding host tissue. In our model, we consider transport processes by an internal, non-solenoidal velocity field. We…

数值分析 · 数学 2024-06-21 Harald Garcke , Dennis Trautwein

Using formal asymptotic methods we derive a free boundary problem representing one of the simplest mathematical descriptions of the growth and death of a tumour or other biological tissue. The mathematical model takes the form of a closed…

组织与器官 · 定量生物学 2019-07-16 Joe Eyles , John F. King , Vanessa Styles

We consider a finite element approximation for a system consisting of the evolution of a curve evolving by forced curve shortening flow coupled to a reaction-diffusion equation on the evolving curve. The curve evolves inside a given domain…

数值分析 · 数学 2020-04-22 Vanessa Styles , James Van Yperen

We consider a one--spatial dimensional tumour growth model [2, 3, 4] that consists of three dependent variables of space and time: volume fraction of tumour cells, velocity of tumour cells, and nutrient concentration. The model variables…

数值分析 · 数学 2020-07-01 Jerome Droniou , Neela Nataraj , Gopikrishnan Chirappurathu Remesan

Mechanical models for tumor growth have been used extensively in recent years for the analysis of medical observations and for the prediction of cancer evolution based on imaging analysis. This work deals with the numerical approximation of…

数值分析 · 数学 2015-04-24 Konstantina Trivisa , Franziska Weber

A finite element approach for approximating the solution of a mathematical model for the response of a penetrable, bounded object (obstacle) to the excitation by an external electromagnetic field is presented and investigated. The model…

数值分析 · 数学 2026-04-16 Lutz Angermann

In this paper, we consider a mathematical model for the invasion of host tissue by tumour cells in a $d$-dimensional bounded domain, $d\leq 3$. This model consists of a system of differential equations describing the evolution of cancer…

In this work, we consider a diffuse interface model for tumour growth in the presence of a nutrient which is consumed by the tumour. The system of equations consists of a Cahn--Hilliard equation with source terms for the tumour cells and a…

数值分析 · 数学 2022-05-09 Harald Garcke , Dennis Trautwein

We propose a diffuse interface model to describe tumor as a multicomponent deformable porous medium. We include mechanical effects in the model by coupling the mass balance equations for the tumor species and the nutrient dynamics to a…

偏微分方程分析 · 数学 2021-09-23 Pavel Krejci , Elisabetta Rocca , Juergen Sprekels

Phase transition problems on curved surfaces can lead to a panopticon of fascinating patterns. In this paper we consider finite element approximations of phase field models with a spatially inhomogeneous and anisotropic surface energy…

数值分析 · 数学 2025-06-09 Harald Garcke , Robert Nürnberg

We present a convergence result for the finite volume method applied to a particular phase field problem suitable for simulation of pure substance solidification. The model consists of the heat equation and the phase field equation with a…

数值分析 · 数学 2020-10-14 Aleš Wodecki , Pavel Strachota , Michal Beneš

Phase-field models of tumour growth have proved useful as theoretical tools to investigate cancer invasion. A key implicit assumption underlying mathematical models of this type which have so far been proposed, though, is that cells in the…

偏微分方程分析 · 数学 2025-07-08 Tommaso Lorenzi , Giulia Pozzi , Andrea Signori

This work is devoted to design and study efficient and accurate numerical schemes to approximate a chemo-attraction model with consumption effects, which is a nonlinear parabolic system for two variables; the cell density and the…

数值分析 · 数学 2023-01-31 F. Guillén-González , G. Tierra

We consider the asymptotic limit of a diffuse interface model for tumor-growth when a parameter $\varepsilon$ proportional to the thickness of the diffuse interface goes to zero. An approximate solution which shows explicitly the behavior…

偏微分方程分析 · 数学 2017-08-25 Mingwen Fei , Tao Tao , Wei Wang

We present a two-dimensional continuum model of tumor growth, which treats the tissue as a composition of six distinct fluid phases; their dynamics are governed by the equations of mass and momentum conservation. Our model divides the…

种群与进化 · 定量生物学 2021-02-12 I. Lampropoulos , M. Kavousanakis

This paper presents a convergence analysis of the evolving surface finite element method (ESFEM) applied to the original Eyles-King-Styles model of tumour growth. The model consists of a Poisson equation in the bulk, a forced mean curvature…

数值分析 · 数学 2025-08-07 Yifei Li

In this survey article, a variety of systems modeling tumor growth are discussed. In accordance with the hallmarks of cancer, the described models incorporate the primary characteristics of cancer evolution. Specifically, we focus on…

动力系统 · 数学 2023-03-21 Marvin Fritz

A novel numerical technique has been proposed to solve a two-phase tumour growth model in one spatial dimension without needing to account for the boundary dynamics explicitly. The equivalence to the standard definition of a weak solution…

数值分析 · 数学 2019-02-19 Gopikrishnan C. Remesan

This paper is devoted to the design and analysis of a numerical algorithm for approximating solutions of a degenerate cross-diffusion system, which models particular instances of taxis-type migration processes under local sensing…

数值分析 · 数学 2025-10-09 Juan Vicente Gutiérrez-Santacreu

We consider a biphasic continuum model for avascular tumour growth in two spatial dimensions, in which a cell phase and a fluid phase follow conservation of mass and momentum. A limiting nutrient that follows a diffusion process controls…

数值分析 · 数学 2020-10-21 Jerome Droniou , Jennifer A. Flegg , Gopikrishnan C. Remesan
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