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This study proposes an effective positive control design strategy for cancer treatment by resorting to the combination of immunotherapy and chemotherapy. The treatment objective is to transfer the initial number of tumor cells and…

系统与控制 · 电气工程与系统科学 2019-12-17 Elham Ahmadi , Jafar Zarei , Roozbeh Razavi-Far , Mehrdad Saif

The paper should be viewed as complement of an earlier result in [8]. In the paper just mentioned it is shown that 1d case of a quasilinear parabolic-elliptic Keller-Segel system is very special. Namely, unlike in higher dimensions, there…

偏微分方程分析 · 数学 2017-05-25 Tomasz Cieślak , Kentarou Fujie

In this paper, we prove global-in-time existence of strong solutions to a class of fractional parabolic reaction-diffusion systems posed in a bounded domain of $\mathbb{R}^N$. The nonlinear reactive terms are assumed to satisfy natural…

偏微分方程分析 · 数学 2023-06-07 Maha Daoud , El-Haj Laamri , Azeddine Baalal

A re-entrant manufacturing system producing a large number of items and involving many steps can be approximately modeled by a hyperbolic partial differential equation (PDE) according to mass conservation law with respect to a continuous…

最优化与控制 · 数学 2016-11-15 Xiaodong Xu , Stevan Dubljevic

This paper investigates an optimal control problem associated with a two-dimensional multi-species Cahn-Hilliard-Keller-Segel tumor growth model, which incorporates complex biological processes such as species diffusion, chemotaxis,…

偏微分方程分析 · 数学 2024-07-26 Pierluigi Colli , Gianni Gilardi , Andrea Signori , Jürgen Sprekels

The traditional quantum control theory focuses on linear quantum system. Here we show the effect of nonlinearity on quantum control of a two-level system, we find that the nonlinearity can change the controllability of quantum system.…

量子物理 · 物理学 2015-05-13 W. Wang , J. Shen , X. X. Yi

In a separable Hilbert space $X$, we study the controlled evolution equation \begin{equation*} u'(t)+Au(t)+p(t)Bu(t)=0, \end{equation*} where $A\geq-\sigma I$ ($\sigma\geq0$) is a self-adjoint linear operator, $B$ is a bounded linear…

最优化与控制 · 数学 2021-05-13 Fatiha Alabau-Boussouira , Piermarco Cannarsa , Cristina Urbani

We construct solutions to the two dimensional parabolic-elliptic Keller-Segel model for chemotaxis that blow up in finite time $T$. The solution is decomposed as the sum of a stationary state concentrated at scale $\lambda$ and of a…

偏微分方程分析 · 数学 2021-02-05 Charles Collot , Tej-Eddine Ghoul , Nader Masmoudi , Van Tien Nguyen

We consider a biphasic continuum model for avascular tumour growth in two spatial dimensions, in which a cell phase and a fluid phase follow conservation of mass and momentum. A limiting nutrient that follows a diffusion process controls…

数值分析 · 数学 2020-10-21 Jerome Droniou , Jennifer A. Flegg , Gopikrishnan C. Remesan

In this paper, a reaction-diffusion system modeling injection of a chemotherapeutic drug on the surface of a living tissue during a treatment for cancer patients is studied. The system describes the interaction of the chemotherapeutic drug…

偏微分方程分析 · 数学 2024-08-20 Jeff Morgan , Bao Quoc Tang , Hong-Ming Yin

This work concentrates on a class of optimal control problems for semilinear parabolic equations subject to control constraint of the form $\|u(t)\|_{L^1(\Omega)} \le \gamma$ for $t \in (0,T)$. This limits the total control that can be…

最优化与控制 · 数学 2021-12-03 Eduardo Casas , Karl Kunisch

This article deals with an initial-boundary value problem for the coupled chemotaxis-haptotaxis system with nonlinear diffusion \begin{align*} u_t=&\nabla\cdot(D(u)\nabla u)-\chi\nabla\cdot(u\nabla v)-\xi\nabla\cdot(u\nabla w)+\mu…

偏微分方程分析 · 数学 2016-04-20 Yan Li , Johannes Lankeit

We consider the quasilinear parabolic-parabolic Keller-Segel system $$ u_t=\nabla \cdot (D(u)\nabla u) - \nabla \cdot (S(u)\nabla v), \qquad x\in\Omega, \ t>0, v_t=\Delta v -v + u, x\in\Omega, \ t>0, $$ under homogeneous Neumann boundary…

偏微分方程分析 · 数学 2011-06-28 Youshan Tao , Michael Winkler

This paper is concerned with optimal control problems for parabolic partial differential equations with pointwise in time switching constraints on the control. A standard approach to treat constraints in nonlinear optimization is…

最优化与控制 · 数学 2018-04-30 Christian Clason , Armin Rund , Karl Kunisch

The two contributions of this paper are as follows. The first is the solution of an infinite dimensional, boundary controlled Linear Quadratic Regulator by the simple and constructive method of completing the square. The second contribution…

最优化与控制 · 数学 2022-07-13 Arthur J. Krener

We consider a bilinear optimal control for an evolution equation involving the fractional Laplace operator of order $0<s<1$. We first give some existence and uniqueness results for the considered evolution equation. Next, we establish some…

最优化与控制 · 数学 2024-11-26 Gisèle Mophou , Cyrille Kenne , Mahamadi Warma

We consider a nonlinear reaction diffusion system of parabolic type known as the monodomain equations, which model the interaction of the electric current in a cell. Together with the FitzHugh-Nagumo model for the nonlinearity they…

最优化与控制 · 数学 2021-01-27 Thomas Berger , Tobias Breiten , Marc Puche , Timo Reis

This paper is concerned with the state-constrained optimal control of the three-dimensional thermistor problem, a fully quasilinear coupled system of a parabolic and elliptic PDE with mixed boundary conditions. This system models the…

最优化与控制 · 数学 2018-07-02 Hannes Meinlschmidt , Christian Meyer , Joachim Rehberg

We study a system of two coupled nonlinear parabolic equations. It constitutes a variant of the Keller-Segel model for chemotaxis, i.e. it models the behaviour of a population of bacteria that interact by means of a signalling substance. We…

偏微分方程分析 · 数学 2015-05-14 Jonathan Zinsl , Daniel Matthes

We consider a linear Schr\"odinger equation, on a bounded interval, with bilinear control, that represents a quantum particle in an electric field (the control). We prove the controllability of this system, in any positive time, locally…

偏微分方程分析 · 数学 2010-01-20 Karine Beauchard , Camille Laurent