相关论文: Parameter identification via optimal control for a…
This paper explores the reconstruction of a space-dependent parameter in inverse diffusion problems, proposing a shape-optimization-based approach. We consider a Robin boundary condition, physically motivated in diffuse optical tomography…
We introduce here a new diffuse interface thermodynamically consistent non-isothermal model for tumor growth in presence of a nutrient in a domain $\Omega \subset \mathbb{R}^3$. In particular our system describes the growth of a tumor…
We propose a new type of diffuse interface model describing the evolution of a tumor mass under the effects of a chemical substance (e.g., a nutrient or a drug). The process is described by utilizing the variables $\varphi$, an order…
We consider a one--spatial dimensional tumour growth model [2, 3, 4] that consists of three dependent variables of space and time: volume fraction of tumour cells, velocity of tumour cells, and nutrient concentration. The model variables…
Parameters in mathematical models for glioblastoma multiforme (GBM) tumour growth are highly patient specific. Here we aim to estimate parameters in a Cahn-Hilliard type diffuse interface model in an optimised way using model order…
We present a numerical scheme for solving a parameter estimation problem for a model of low-grade glioma growth. Our goal is to estimate the spatial distribution of tumor concentration, as well as the magnitude of anisotropic tumor…
The aim of this paper is to discuss potential advances in PET kinetic models and direct reconstruction of kinetic parameters. As a prominent example we focus on a typical task in perfusion imaging and derive a system of…
We consider a diffuse interface model of tumor growth proposed by A.~Hawkins-Daruud et al. This model consists of the Cahn-Hilliard equation for the tumor cell fraction $\varphi$ nonlinearly coupled with a reaction-diffusion equation for…
We introduce a multi-species diffuse interface model for tumor growth, characterized by its incorporation of essential features related to chemotaxis, angiogenesis and proliferation mechanisms. We establish the weak well-posedness of the…
In this paper, we study the optimal control of a phase field model for a tumor growth model of Cahn--Hilliard type in which the often assumed parabolic relaxation of the chemical potential is replaced by a hyperbolic one. Both the cases…
In this paper, we study an optimal control problem for a nonlinear system of reaction-diffusion equations that constitutes a simplified and relaxed version of a thermodynamically consistent phase field model for tumor growth originally…
Motivated by an ongoing collaboration with clinical oncologists and pathologists, we develop a hybrid partial differential equation--ordinary differential equation (PDE--ODE) framework that captures (i) competition between susceptible and…
We consider a biphasic continuum model for avascular tumour growth in two spatial dimensions, in which a cell phase and a fluid phase follow conservation of mass and momentum. A limiting nutrient that follows a diffusion process controls…
We study a tumor growth model in two space dimensions, where proliferation of the tumor cells leads to expansion of the tumor domain and migration of surrounding normal tissues into the exterior vacuum. The model features two moving…
We study the existence of weak solutions to a mixture model for tumour growth that consists of a Cahn--Hilliard--Darcy system coupled with an elliptic reaction-diffusion equation. The Darcy law gives rise to an elliptic equation for the…
We provide an overview of an optimal control problem within a stochastic model of tumor growth, which includes drug application. The model comprises two stochastic differential equations (SDE) representing the diffusion of nutrient and drug…
We study an initial-boundary value problem (IBVP) for a coupled Cahn-Hilliard-Hele-Shaw system that models tumor growth. For large initial data with finite energy, we prove global (local resp.) existence, uniqueness, higher order spatial…
We pursue a computational analysis of the biomedical problem on the identification of the cancerous tumor at an early stage of development based on the Electrical Impedance Tomography (EIT) and optimal control of elliptic partial…
We consider the problem of the long time dynamics for a diffuse interface model for tumor growth. The model describes the growth of a tumor surrounded by host tissues in the presence of a nutrient and consists in a Cahn-Hilliard-type…
In this work, we investigate a distributed optimal control problem for an extended phase field system of Cahn--Hilliard type which physical context is that of tumor growth dynamics. In a previous contribution, the author has already studied…