相关论文: Free boundary problems for Tumor Growth: a Viscosi…
In this paper, a free boundary problem modelling the growth of tumor is considered. The model includes two reaction-diffusion equations modelling the diffusion of nutrient and drug in the tumor and three hyperbolic equations describing the…
Cancer is a very complex phenomenon that involves many different scales and situations. In this paper we consider a free boundary problem describing the evolution of a tumor colony and we derive a new asymptotic model for tumor growth. We…
We study the free boundary regularity of the traveling wave solutions to a degenerate advection-diffusion problem of Porous Medium type, whose existence was proved in \cite{MonsaingonNovikovRoquejoffre}. We set up a finite difference scheme…
We consider a macroscopic model for the growth of living tissues incorporating pressure-driven dispersal and pressure-modulated proliferation. Assuming a power-law relation between the mechanical pressure and the cell density, the model can…
We study the long-time behavior of an exterior Hele-Shaw problem in random media with a free boundary velocity that depends on position in dimensions $n \geq 2$. A natural rescaling of solutions that is compatible with the evolution of the…
This paper provides a unified mathematical analysis of a family of non-local diffuse interface models for tumor growth describing evolutions driven by long-range interactions. These integro-partial differential equations model cell-to-cell…
In this paper we study a free boundary problem modeling the growth of solid tumor spheroid. It consists of two elliptic equations describing nutrient diffusion and pressure distribution within tumor, respectively. The new feature is that…
This paper is concerned with a multi-dimensional free boundary problem modeling the growth of a tumor with two species of cells: proliferating cells and quiescent cells. This free boundary problem has a unique radial stationary solution. By…
In this work, we study a model consisting of a Cahn-Hilliard-type equation for the concentration of tumour cells coupled to a reaction-diffusion type equation for the nutrient density and a Brinkman-type equation for the velocity. We equip…
In this paper we study the rigorous sharp interface limit of a diffuse interface model related to the dynamics of tumor growth, when a parameter $\epsilon$, representing the interface thickness between the tumorous and non tumorous cells,…
The free boundary problem for a two-dimensional fluid filtered in porous media is studied. This is known as the one-phase Muskat problem and is mathematically equivalent to the vertical Hele-Shaw problem driven by gravity force. We prove…
We investigate two-phase flow in porous media and derive a two-scale model, which incorporates pore-scale phase distribution and surface tension into the effective behavior at the larger Darcy scale. The free-boundary problem at the pore…
Several mathematical models of tumor growth are now commonly used to explain medical observations and predict cancer evolution based on images. These models incorporate mechanical laws for tissue compression combined with rules for…
We investigate the tumor boundary instability induced by nutrient consumption and supply based on a Hele-Shaw model derived from taking the incompressible limit of a cell density model. We analyze the boundary stability/instability in two…
A two-dimensional free boundary model for the growth of multi-layer tumors has been proposed in [S. Cui, J. Escher: ARMA 191 (2009) 173-193] where the authors derive well-posedness in a functional analytic setting, the stationary solutions…
In this work we will study the dynamics of a thin layer of a viscous fluid which is embedded in the interior of another viscous fluid. The resulting flow can be approximated by means of the solutions of a free boundary problem for the…
Motivated by biological applications on tumour invasion through thin membranes, we study a porous-medium type equation where the density of the cell population evolves under Darcy's law, assuming continuity of both the density and flux…
In this paper, we study a nonlinear free boundary problem modeling the growth of spherically symmetric tumors. The tumor consists of a central necrotic core, an intermediate annual quiescent-cell layer, and an outer proliferating-cell…
We investigate the dynamics of a nonlinear system modeling tumor growth with drug application. The tumor is viewed as a mixture consisting of proliferating, quiescent and dead cells as well as a nutrient in the presence of a drug. The…
In this paper, we consider an age-structured mechanical model for tumor growth. This model takes into account the life-cycle of tumor cells by including an age variable. The underlying process for tumor growth is the same as classical tumor…