具有突变的多株病毒动力学:全局分析
细胞行为
2007-08-01 v1
摘要
我们考虑了宿主内包含多个毒株并允许毒株间发生突变的病毒模型。若不存在突变,Lyapunov 函数可确立对应于最适毒株的稳态的全局稳定性。对于微小扰动,该稳态得以保持,可能伴随某些或所有其他毒株的微小浓度,具体取决于描述所有可能突变的图的连通性。此外,利用 Smith 和 Waltman 提出的扰动结果,我们证明了该稳态同样保持全局稳定性。
引用
@article{arxiv.0707.4501,
title = {Multi-strain virus dynamics with mutations: A global analysis},
author = {Patrick De Leenheer and Sergei S. Pilyugin},
journal= {arXiv preprint arXiv:0707.4501},
year = {2007}
}
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