相关论文: A high-order discontinuous Galerkin method for the…
Multiscale mathematical models have shown great promise in computational brain electrophysiology but are still hindered by high computational costs due to fast dynamics and complex brain geometries, requiring very fine spatio-temporal…
Mathematical models of protein-protein dynamics, such as the heterodimer model, play a crucial role in understanding many physical phenomena. This model is a system of two semilinear parabolic partial differential equations describing the…
This work aims at presenting a Discontinuous Galerkin (DG) formulation employing a spectral basis for two important models employed in cardiac electrophysiology, namely the monodomain and bidomain models. The use of DG methods is motivated…
Neurocognitive disorders, such as Alzheimer's and Parkinson's, have a wide social impact. These proteinopathies involve misfolded proteins accumulating into neurotoxic aggregates. Mathematical and computational models describing the…
This spreading of prion proteins is at the basis of brain neurodegeneration. This paper deals with the numerical modelling of the misfolding process of $\alpha$-synuclein in Parkinson's disease. We introduce and analyze a discontinuous…
We introduce and analyze a discontinuous Galerkin method for the numerical modelling of the equations of Multiple-Network Poroelastic Theory (MPET) in the dynamic formulation. The MPET model can comprehensively describe functional changes…
The embedded discontinuous Galerkin (EDG) method by Cockburn et al. [SIAM J. Numer. Anal., 2009, 47(4), 2686-2707] is obtained from the hybridizable discontinuous Galerkin method by changing the space of the Lagrangian multiplier from…
We present a numerical approximation of Darcy's flow through a porous medium that incorporates networks of fractures with non empty intersection. Our scheme employs PolyDG methods, i.e. discontinuous Galerkin methods on general polygonal…
We propose a family of high-order local discontinuous Galerkin (LDG) methods, built on a parametric representation and coupled with a semi-implicit backward Euler time discretization, for isotropic and anisotropic curve-shortening flows.…
The aim of this work is to introduce and analyze a finite element discontinuous Galerkin method on polygonal meshes for the numerical discretization of acoustic waves propagation through poroelastic materials. Wave propagation is modeled by…
A comprehensive mathematical model of the multiphysics flow of blood and Cerebrospinal Fluid (CSF) in the brain can be expressed as the coupling of a poromechanics system and Stokes' equations: the first describes fluids filtration through…
Modeling and simulating how oxygen supply shapes neuronal excitability is crucial for advancing the understanding of brain function in pathological scenarios, such as ischemia. This condition is caused by a reduced blood supply, leading to…
We formulate and analyze interior penalty discontinuous Galerkin methods for coupled elliptic PDEs modeling excitable tissue, represented by intracellular and extracellular domains sharing a common interface. The PDEs are coupled through a…
In this work we review discontinuous Galerkin finite element methods on polytopal grids (PolydG) for the numerical simulation of multiphysics wave propagation phenomena in heterogeneous media. In particular, we address wave phenomena in…
In this paper, we develop a local multiscale model reduction strategy for the elastic wave equation in strongly heterogeneous media, which is achieved by solving the problem in a coarse mesh with multiscale basis functions. We use the…
We present and analyze a high-order discontinuous Galerkin method for the space discretization of the wave propagation model in thermo-poroelastic media. The proposed scheme supports general polytopal grids. Stability analysis and…
We present a new high-order accurate Lagrangian discontinuous Galerkin (DG) hydrodynamic method to simulate material dynamics (for e.g., gasses, fluids, and solids) with up to fourth-order accuracy on cubic meshes. The variables, such as…
Patients with epilepsy can manifest short, sub-clinical epileptic "bursts" in addition to full-blown clinical seizures. We believe the relationship between these two classes of events---something not previously studied…
A high-order accurate implicit-mesh discontinuous Galerkin framework for wave propagation in single-phase and bi-phase solids is presented. The framework belongs to the embedded-boundary techniques and its novelty regards the spatial…
Many neurodegenerative diseases are connected to the spreading of misfolded prionic proteins. In this paper, we analyse the process of misfolding and spreading of both $\alpha$-synuclein and Amyloid-$\beta$, related to Parkinson's and…