相关论文: Theoretical analysis for a PDE-ODE system related …
In this work we analyse a PDE-ODE problem modelling the evolution of a Glioblastoma, which includes an anisotropic nonlinear diffusion term with a diffusion velocity increasing with respect to vasculature. First, we prove the existence of…
In this work we analyse a PDE-ODE problem modelling the evolution of a Glioblastoma, which includes chemotaxis term directed to vasculature. First, we obtain some a priori estimates for the (possible) solutions of the model. In particular,…
In this paper, we consider a model with tumor microenvironment involving nutrient density, extracellular matrix and matrix-degrading enzymes, which satisfy a coupled system of PDEs with a free boundary. For this coupled parabolic-hyperbolic…
We propose and study a strongly coupled PDE-ODE system with tissue-dependent degenerate diffusion and haptotaxis that can serve as a model prototype for cancer cell invasion through the extracellular matrix. We prove the global existence of…
In this paper, we study the global dynamics of a general reaction-diffusion model based on acid-mediated invasion hypothesis, which is a candidate explanation for the Warburg effect. A key feature of this model is the density-limited tumor…
We present a mathematical analysis of a mixed ODE-PDE model describing the spatial distribution and temporal evolution of tumor and normal cells within a tissue subject to the effects of a chemotherapeutic drug. The model assumes that the…
We study the asymptotic behavior of solutions of one coupled PDE-ODE system arising in mathematical biology as a model for the development of a forest ecosystem. In the case where the ODE-component of the system is monotone, we establish…
Motivated by an ongoing collaboration with clinical oncologists and pathologists, we develop a hybrid partial differential equation--ordinary differential equation (PDE--ODE) framework that captures (i) competition between susceptible and…
We propose and study a strongly coupled PDE-ODE-ODE system modeling cancer cell invasion through a tissue network under the go-or-grow hypothesis asserting that cancer cells can either move or proliferate. Hence our setting features two…
We propose a diffuse interface model to describe tumor as a multicomponent deformable porous medium. We include mechanical effects in the model by coupling the mass balance equations for the tumor species and the nutrient dynamics to a…
In this paper we investigate the existence of solutions and their weak-strong uniqueness property for a PDE system modelling damage in viscoelastic materials. In fact, we address two solution concepts, weak and strong solutions. For the…
The purpose of this paper is to establish Picard-Lindel\"{o}f theorem for local uniqueness and existence results for first-order systems of nonlinear delay dynamic equations. In the linear case, we extend our results to global existence and…
The object of this paper is a one-dimensional generalized porous media equation (PDE) with possibly discontinuous coefficient $\beta$, which is well-posed as an evolution problem in $L^1(\mathbb{R})$. In some recent papers of Blanchard et…
In this paper, we study a cancer invasion model both theoretically and numerically. The model is a nonstationary, nonlinear system of three coupled partial differential equations modeling the motion of cancer cells, degradation of the…
Recent biological evidence suggests the presence of a two-phase ageing process in several species. We introduce a system of two age-structured partial differential equations (PDE) representing two phases of ageing of a wild population. The…
In this article a generalized mathematical model describing the interactions between malignant tumour and immune system with discrete time delay incorporated into the system is considered. Time delay represents the time required to generate…
In this study, we consider a system of degenerate reaction-diffusion equations, which govern the electric activity in the heart with a diffusion term modeling the potential in the surrounding tissue and the nonlinear ionic model proposed by…
This work considers a system coupling a viscous Burgers equation (aimed to describe a simplified model of $1D$ fluid flow) with the ODE describing the motion of a point mass moving inside the fluid. The point mass is possibly under the…
This paper is concerned with the well-posedness and large-time behavior of a two dimensional PDE-ODE hybrid chemotaxis system describing the initiation of tumor angiogenesis. We first transform the system via a Cole-Hopf type transformation…
We consider a strongly nonlinear PDE system describing solid-solid phase transitions in shape memory alloys. The system accounts for the evolution of an order parameter (related to different symmetries of the crystal lattice in the phase…