相关论文: Sharp interface limit of a diffuse interface model…
In this paper we study the rigorous sharp interface limit of a diffuse interface model related to the dynamics of tumor growth, when a parameter $\epsilon$, representing the interface thickness between the tumorous and non tumorous cells,…
We discuss the sharp interface limit of a diffuse interface model for a coupled Cahn-Hilliard--Darcy system that models tumor growth when a certain parameter $\varepsilon>0$, related to the interface thickness, tends to zero. In particular,…
In this paper we consider two diffuse interface models for tumor growth coupling a Cahn-Hilliard type equation for the tumor phase parameter to a reaction-diffusion type equation for the nutrient. The models are distinguished by the…
We discuss the sharp interface limit of a diffuse interface model for a two-phase flow of two partly miscible viscous Newtonian fluids of different densities, when a certain parameter \epsilon>0 related to the interface thickness tends to…
We consider a diffuse interface model for tumor growth recently proposed in [Y. Chen, S.M. Wise, V.B. Shenoy, J.S. Lowengrub, A stable scheme for a nonlinear, multiphase tumor growth model with an elastic membrane, Int. J. Numer. Methods…
We consider a diffuse interface model of tumor growth proposed by A.~Hawkins-Daruud et al. This model consists of the Cahn-Hilliard equation for the tumor cell fraction $\varphi$ nonlinearly coupled with a reaction-diffusion equation for…
Using formal asymptotic methods we derive a free boundary problem representing one of the simplest mathematical descriptions of the growth and death of a tumour or other biological tissue. The mathematical model takes the form of a closed…
We consider the sharp interface limit of a coupled Stokes/Allen-Cahn system, when a parameter $\varepsilon>0$ that is proportional to the thickness of the diffuse interface tends to zero, in a two dimensional bounded domain. For…
We formulate a general shape and topology optimization problem in structural optimization by using a phase field approach. This problem is considered in view of well-posedness and we derive optimality conditions. We relate the diffuse…
We consider the problem of the long time dynamics for a diffuse interface model for tumor growth. The model describes the growth of a tumor surrounded by host tissues in the presence of a nutrient and consists in a Cahn-Hilliard-type…
We consider a fully practical finite element approximation of a diffuse interface model for tumour growth that takes the form of a degenerate parabolic system. In addition to showing stability bounds for the approximation, we prove…
We consider a system of two coupled parabolic PDEs introduced in [1] to model motility of eukaryotic cells. We study the asymptotic behavior of solutions in the limit of a small parameter related to the width of the interface in phase field…
We introduce here a new diffuse interface thermodynamically consistent non-isothermal model for tumor growth in presence of a nutrient in a domain $\Omega \subset \mathbb{R}^3$. In particular our system describes the growth of a tumor…
The mathematical modeling of tumor growth leads to singular stiff pressure law limits for porous medium equations with a source term. Such asymptotic problems give rise to free boundaries, which, in the absence of active motion, are…
We study a tumor growth model in two space dimensions, where proliferation of the tumor cells leads to expansion of the tumor domain and migration of surrounding normal tissues into the exterior vacuum. The model features two moving…
We construct rigorously suitable approximate solutions to the Stokes/Cahn-Hilliard system by using the method of matched asymptotics expansions. This is a main step in the proof of convergence given in the first part of this contribution,…
We study a non-local variant of a diffuse interface model proposed by Hawkins--Darrud et al. (2012) for tumour growth in the presence of a chemical species acting as nutrient. The system consists of a Cahn--Hilliard equation coupled to a…
In this letter, we derive the sharp-interface limit of the Cahn-Hilliard-Biot equations using formal matched asymptotic expansions. We find that in each sub-domain, the quasi-static Biot equations are obtained with domain-specific material…
The use of continuum phase-field models to describe the motion of well-defined interfaces is discussed for a class of phenomena, that includes order/disorder transitions, spinodal decomposition and Ostwald ripening, dendritic growth, and…
The thin interface limit aims at minimizing the effects arising from a numerical interface thickness, inherent in diffuse interface models of solidification and microstructure evolution such as the phase field model. While the original…