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Objectives: In this study, we quantify the growth variability of tumour cell clones from a human leukemia cell line. Materials and methods: We have used microplate spectrophotometry to measure the growth kinetics of hundreds of individual…

细胞行为 · 定量生物学 2007-05-23 C. Tomelleri , E. Milotti , C. Dalla Pellegrina , O. Perbellini , A. Del Fabbro , M. T. Scupoli , R. Chignola

Major efforts to sequence cancer genomes are now occurring throughout the world. Though the emerging data from these studies are illuminating, their reconciliation with epidemiologic and clinical observations poses a major challenge. In the…

Knowledge regarding the kinetics of metastatic tumor formation, as related to the growth of the primary tumor, represents a fundamental issue in cancer biology. Using an in vivo mammalian model, we show here that one can obtain useful…

组织与器官 · 定量生物学 2007-05-23 Steve P. Lee , Ji-Rong Sun , Hong Qian , William H. McBride , H. Rodney Withers

The ordinary contact process is used to model the spread of a disease in a population. In this model, each infected individual waits an exponentially distributed time with parameter 1 before becoming healthy. In this paper, we introduce and…

概率论 · 数学 2011-11-10 Erik I. Broman

We consider growing random recursive trees in random environment, in which at each step a new vertex is attached (by an edge of a random length) to an existing tree vertex according to a probability distribution that assigns the tree…

概率论 · 数学 2007-05-23 Konstantin Borovkov , Vladimir Vatutin

In this thesis we develop minimal models of the relationship between motility, growth, and evolution of cancer cells. We utilise simple simulations of a population of individual cells in space to examine how changes in mechanical properties…

种群与进化 · 定量生物学 2020-05-20 Chay Paterson

Go-or-grow approaches represent a specific class of mathematical models used to describe populations where individuals either migrate or reproduce, but not both simultaneously. These models have a wide range of applications in biology and…

细胞行为 · 定量生物学 2026-02-24 R. Thiessen , M. Conte , T. L. Stepien , T. Hillen

A continuous time random walk (CTRW) model with waiting times following the Levy-stable distribution with exponential cut-off in equilibrium is a simple theoretical model giving rise to normal, yet non-Gaussian diffusion. The distribution…

数据分析、统计与概率 · 物理学 2017-05-31 S. M. J. Khadem , I. M. Sokolov

We analyze generalized space-time fractional motions on undirected networks and lattices. The continuous-time random walk (CTRW) approach of Montroll and Weiss is employed to subordinate a space fractional walk to a generalization of the…

We consider a stochastic individual-based model of adaptive dynamics for an asexually reproducing population with mutation, with linear birth and death rates, as well as a density-dependent competition. To depict repeating changes of the…

种群与进化 · 定量生物学 2025-05-28 Manuel Esser , Anna Kraut

Logarithmic growth-rates are fundamental observables for describing ecological systems and the characterization of their distributions with analytical techniques can greatly improve their comprehension. Here a neutral model based on a…

种群与进化 · 定量生物学 2025-01-24 E. Brigatti , S. Azaele

Community assembly is studied using individual-based multispecies models. The models have stochastic population dynamics with mutation, migration, and extinction of species. Mutants appear as a result of mutation of the resident species,…

种群与进化 · 定量生物学 2010-05-18 Yohsuke Murase , Takashi Shimada , Nobuyasu Ito , Per Arne Rikvold

Quantitative assessment of the growth of biological organisms has produced many mathematical equations. Many efforts have been given on statistical identification of the correct growth model from experimental data. Every growth equation is…

统计方法学 · 统计学 2021-02-17 Md Aktar Ul Karim , Supriya Ramdas Bhagat , Amiya Ranjan Bhowmick

Growth patterns generated by filamentous organisms (e.g. actinomycetes and fungi) involve spatial and temporal dynamics at different length scales. Several mathematical models have been proposed in the last thirty years to address these…

种群与进化 · 定量生物学 2007-05-23 Michele Bezzi , Andrea Ciliberto

Textual analysis of typical microbial genomes reveals that they have the statistical characteristics of a DNA sequence of a much shorter length. This peculiar property supports an evolutionary model in which a genome evolves by random…

生物物理 · 物理学 2009-11-07 L. C. Hsieh , L. F. Luo , F. M. Ji , H. C. Lee

Continuous Time Random Walk(CTRW) is a model where particle's jumps in space are coupled with waiting times before each jump. A Continuous Time Random Walk Limit(CTRWL) is obtained by a limit procedure on a CTRW and can be used to model…

概率论 · 数学 2016-02-12 Ofer Busani

We give a very short introduction to discrete and continuum models for the evolutionary and spatial dynamics of cancer through two case studies: a model for the evolutionary dynamics of cancer cells under cytotoxic therapy and a model for…

组织与器官 · 定量生物学 2019-11-07 Tommaso Lorenzi , Fiona R. Macfarlane , Chiara Villa

Based on the Langevin description of the Continuous Time Random Walk (CTRW), we consider a generalization of CTRW in which the waiting times between the subsequent jumps are correlated. We discuss the cases of exponential and slowly…

统计力学 · 物理学 2015-05-13 A. V. Chechkin , M. Hofmann , I. M. Sokolov

Cancer is a disease that takes millions of lives every year. Then, to propose treatments, avoid recurrence, and improve the patient's life quality, we need to analyze this disease from a biophysical perspective with a solid mathematical…

定量方法 · 定量生物学 2024-07-09 Carlos M. Nieto , Oscar M. Pimentel , Fabio D. Lora-Clavijo

We consider a model of interface growth in two dimensions, given by a height function on the sites of the one--dimensional integer lattice. According to the discrete time update rule, the height above the site $x$ increases to the height…

概率论 · 数学 2007-05-23 Janko Gravner , Craig A. Tracy , Harold Widom