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This paper is concerned with a phase field system of Cahn-Hilliard type that is related to a tumor growth model and consists of three equations in terms of the variables order parameter, chemical potential and nutrient concentration. This…

偏微分方程分析 · 数学 2015-03-04 Pierluigi Colli , Gianni Gilardi , Elisabetta Rocca , Jürgen Sprekels

The paper deals with a phase field system of Cahn-Hilliard type. For positive viscosity coefficients, the authors prove an existence and uniqueness result and study the long time behavior of the solution by assuming the nonlinearities to be…

偏微分方程分析 · 数学 2014-03-24 Pierluigi Colli , Gianni Gilardi , Danielle Hilhorst

A distributed optimal control problem for a phase field system which physical context is that of tumor growth is discussed. The system we are going to take into account consists of a Cahn-Hilliard equation for the phase variable (relative…

偏微分方程分析 · 数学 2021-01-20 Andrea Signori

We consider a particular phase field system which physical context is that of tumor growth dynamics. The model we deal with consists of a Cahn-Hilliard type equation governing the evolution of the phase variable which takes into account the…

偏微分方程分析 · 数学 2019-08-30 Andrea Signori

We introduce a new diffuse interface model for tumour growth in the presence of a nutrient, in which we take into account mechanical effects and reversible tissue damage. The highly nonlinear PDEs system mainly consists of a Cahn-Hilliard…

偏微分方程分析 · 数学 2025-10-09 Giulia Cavalleri

In this paper, we study a phase field model for a tumor growth model of Cahn--Hilliard type in which the often assumed parabolic relaxation of the chemical potential is replaced by a hyperbolic one. We show that the resulting…

偏微分方程分析 · 数学 2026-02-16 Pierluigi Colli , Elisabetta Rocca , Jürgen Sprekels

This article considers a limit system by passing to the limit in the following Cahn--Hilliard type phase field system related to tumor growth as $\beta\searrow0$: \begin{equation*} \begin{cases} \alpha\partial_{t} \mu_{\beta} + \partial_{t}…

偏微分方程分析 · 数学 2019-05-01 Shunsuke Kurima

This paper is concerned with a diffusion model of phase-field type, consisting of a parabolic system of two partial differential equations, interpreted as balances of microforces and microenergy, for two unknowns: the problem's order…

偏微分方程分析 · 数学 2011-09-16 Pierluigi Colli , Gianni Gilardi , Paolo Podio-Guidugli , Jürgen Sprekels

In this paper, we study a system of three evolutionary operator equations involving fractional powers of selfadjoint, monotone, unbounded, linear operators having compact resolvents. This system constitutes a generalized and relaxed version…

偏微分方程分析 · 数学 2019-08-29 Pierluigi Colli , Gianni Gilardi , Jürgen Sprekels

We analyze a phase field model for tumor growth consisting of a Cahn-Hilliard-Brinkman system, ruling the evolution of the tumor mass, coupled with an advection-reaction-diffusion equation for a chemical species acting as a nutrient. The…

偏微分方程分析 · 数学 2023-07-26 Pierluigi Colli , Gianni Gilardi , Andrea Signori , Jürgen Sprekels

Mechanical effects have mostly been neglected so far in phase field tumour models that are based on a Cahn-Hilliard approach. In this paper we study a macroscopic mechanical model for tumour growth in which cell-cell adhesion effects are…

偏微分方程分析 · 数学 2021-01-20 Harald Garcke , Kei Fong Lam , Andrea Signori

In this work, we study a model consisting of a Cahn-Hilliard-type equation for the concentration of tumour cells coupled to a reaction-diffusion type equation for the nutrient density and a Brinkman-type equation for the velocity. We equip…

偏微分方程分析 · 数学 2018-11-19 Matthias Ebenbeck , Harald Garcke

In this paper we study nonlocal-to-local asymptotics for a tumor-growth model coupling a viscous Cahn-Hilliard equation describing the tumor proportion with a reaction-diffusion equation for the nutrient phase parameter. First, we prove…

偏微分方程分析 · 数学 2023-11-20 Elisa Davoli , Elisabetta Rocca , Luca Scarpa , Lara Trussardi

We consider an evolutionary PDE system coupling the Cahn-Hilliard equation with singular potential, mass source and transport effects, to a Brinkman-type relation for the macroscopic velocity field and to a further equation describing the…

偏微分方程分析 · 数学 2024-11-20 Giulio Schimperna

We introduce a new phase field model for tumour growth where viscoelastic effects are taken into account. The model is derived from basic thermodynamical principles and consists of a convected Cahn--Hilliard equation with source terms for…

数值分析 · 数学 2024-06-21 Harald Garcke , Balázs Kovács , Dennis Trautwein

We introduce the problem of parameter identification for a coupled nonlocal Cahn-Hilliard-reaction-diffusion PDE system stemming from a recently introduced tumor growth model. The inverse problem of identifying relevant parameters is…

偏微分方程分析 · 数学 2020-09-24 Elisabetta Rocca , Luca Scarpa , Andrea Signori

We are concerned with a nonstandard phase field model of Cahn-Hilliard type. The model, which was introduced by Podio-Guidugli (Ric. Mat. 2006), describes two-species phase segregation and consists of a system of two highly nonlinearly…

偏微分方程分析 · 数学 2012-12-18 Pierluigi Colli , Gianni Gilardi , Pavel Krejčí , Jürgen Sprekels

We investigate the dynamics of a nonlinear system modeling tumor growth with drug application. The tumor is viewed as a mixture consisting of proliferating, quiescent and dead cells as well as a nutrient in the presence of a drug. The…

偏微分方程分析 · 数学 2017-05-23 Donatella Donatelli , Konstantina Trivisa

A phase field model for tumour growth is introduced that is based on a Brinkman law for convective velocity fields. The model couples a convective Cahn-Hilliard equation for the evolution of the tumour to a reaction-diffusion-advection…

偏微分方程分析 · 数学 2021-09-07 Matthias Ebenbeck , Harald Garcke , Robert Nürnberg

We investigate a multiphase Cahn-Hilliard model for tumor growth with general source terms. The multiphase approach allows us to consider multiple cell types and multiple chemical species (oxygen and/or nutrients) that are consumed by the…

偏微分方程分析 · 数学 2022-06-22 Patrik Knopf , Andrea Signori
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