相关论文: Free boundary regularity for tumor growth with nut…
In this paper, we consider a multi-layer tumor model with a periodic provision of external nutrients. The domain occupied by tumor has a different shape (flat shape) than spherical shape which has been studied widely. The important…
We study the macroscopic evolution of the growing cluster in the exactly solvable corner growth model with independent exponentially distributed waiting times. The rates of the exponentials are given by an addivitely separable function of…
Williams and Bjerknes proposed a simple stochastic growth model to describe the tumor growth in the basal layer of an epithelium. In this work we generalize this model by including the possibility of saturation in the tumor growth as it is…
In cancer, treatment failure and disease recurrence have been associated with small subpopulations of cancer cells with a stem-like phenotype. In this paper, we develop and investigate a phenotype-structured model of solid tumour growth in…
We propose a strange-attractor model of tumor growth and metastasis. It is a 4-dimensional spatio-temporal cancer model with strong nonlinear couplings. Even the same type of tumor is different in every patient both in size and appearance,…
The time delayed cytotoxic T-lymphocyte response on the tumor growth has been developed on the basis of discrete approximation (2-dimensional map). The growth kinetic has been described by logistic law with growth rate being the bifurcation…
Tumor development is an evolutionary process in which a heterogeneous population of cells with differential growth capabilities compete for resources in order to gain a proliferative advantage. What are the minimal ingredients needed to…
In this paper, we address an optimal distributed control problem for a non-local model of phase-field type, describing the evolution of tumour cells in presence of a nutrient. The model couples a non-local and viscous Cahn-Hilliard equation…
We consider a free boundary problem for a system of PDEs, modeling the growth of a biological tissue. A morphogen, controlling volume growth, is produced by specific cells and then diffused and absorbed throughout the domain. The geometric…
We examine a lattice model of tumor growth where survival of tumor cells depends on the supplied nutrients. When such a supply is random, the extinction of tumors belongs to the directed percolation universality class. However, when the…
We study the optimal control problem of a free boundary PDE model describing the growth of multilayered tumor tissue in vitro. We seek the optimal amount of tumor growth inhibitor that simultaneously minimizes the thickness of the tumor…
We propose a new model of cancer growth based on nonextensive entropy. The evolution equation depends on the nonextensive parameter q. The exponential, the logistic, and the Gompertz growth laws are particular cases of the generalized…
In this paper study the regularity of continuous casting problem \begin{equation} \hbox{div}(|\nabla u|^{p-2}\nabla u-{\bf v} \beta(u))=0\tag{$\sharp$} \end{equation} for prescribed constant velocity $\bf v$ and enthalpy $\beta(u)$ with…
In this paper, we study an optimal control problem for a nonlinear system of reaction-diffusion equations that constitutes a simplified and relaxed version of a thermodynamically consistent phase field model for tumor growth originally…
The main target of this paper is to present an efficient method to solve a nonlinear free boundary mathematical model of prostate tumor. This model consists of two parabolics, one elliptic and one ordinary differential equations that are…
We study regularity issues for systems of elliptic equations of the type \[ -\Delta u_i=f_{i,\beta}(x)-\beta \sum_{j\neq i} a_{ij} u_i |u_i|^{p-1}|u_j|^{p+1} \] set in domains $\Omega \subset \mathbb{R}^N$, for $N \geq 1$. The paper is…
We present a mathematical model that describes how tumour heterogeneity evolves in a tissue slice that is oxygenated by a single blood vessel. Phenotype is identified with the stemness level of a cell, $s$, that determines its proliferative…
Cancer cell mutations occur when cells undergo multiple cell divisions, and these mutations can be spontaneous or environmentally-induced. The mechanisms that promote and sustain these mutations are still not fully understood. This study…
We present a mathematical analysis of a reaction-diffusion model describing acid-mediated tumor invasion. The model describes the spatial distribution and temporal evolution of tumor cells, normal cells, and excess lactic acid…
Let $M$ be a weighted manifold with boundary $\partial M$, i.e., a Riemannian manifold where a density function is used to weight the Riemannian Hausdorff measures. In this paper we compute the first and the second variational formulas of…