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We analyze a class of network motifs in which a short, two-node positive feed- back motif is inserted in a three-node negative feedback loop. We demonstrate that such networks can undergo a bifurcation to a state where a stable fixed point…

分子网络 · 定量生物学 2012-09-10 Weihan Li , Sandeep Krishna , Simone Pigolotti , Namiko Mitarai , Mogens H. Jensen

Gene regulatory networks, i.e. DNA segments in a cell which interact with each other indirectly through their RNA and protein products, lie at the heart of many important intracellular signal transduction processes. In this paper we analyse…

偏微分方程分析 · 数学 2014-04-03 Mark Chaplain , Mariya Ptashnyk , Marc Sturrock

We experimentally and theoretically investigate the dynamics of inhibitory coupled self-driven oscillators on a star network in which a single central hub node is connected to $k$ peripheral arm nodes. The system consists of water-in-oil…

适应与自组织系统 · 物理学 2019-10-09 Michael M. Norton , Nathan Tompkins , Baptiste Blanc , Matthew C. Cambria , Jesse Held , Seth Fraden

Microresonators are micron-scale optical systems that confine light using total internal reflection. These optical systems have gained interest in the last two decades due to their compact sizes, unprecedented measurement capabilities, and…

Mutation is introduced into autocatalytic reaction networks. Examples of low dimensional dynamical systems --- n = 2, 3 and 4 --- are discussed and complete qualitative analysis is presented. Error thresholds known from simple…

chao-dyn · 物理学 2008-02-03 Peter F. Stadler , Wolfgang Schnabl , Christian V. Forst , Peter Schuster

Computer algebra methods for analyzing reaction networks often rely on the assumption of mass-action kinetics, which transform the governing ODEs into polynomial systems amenable to techniques such as Gr\"obner basis computation and related…

分子网络 · 定量生物学 2025-11-19 Richard Golnik , Thomas Gatter , Peter F. Stadler , Nicola Vassena

Hopf bifurcation in networks of coupled ODEs creates periodic states in which the relative phases of nodes are well defined near bifurcation. When the network is a fully inhomogeneous nearest-neighbour coupled unidirectional ring, and node…

动力系统 · 数学 2024-04-15 Ian Stewart

Bistability plays a central role in the gene regulatory networks (GRNs) controlling many essential biological functions, including cellular differentiation and cell cycle control. However, establishing the network topologies that can…

分子网络 · 定量生物学 2015-03-19 Dan Siegal-Gaskins , Maria Katherine Mejia-Guerra , Gregory D. Smith , Erich Grotewold

Pulse-coupled systems such as spiking neural networks exhibit nontrivial invariant sets in the form of attracting yet unstable saddle periodic orbits where units are synchronized into groups. Heteroclinic connections between such orbits may…

适应与自组织系统 · 物理学 2020-11-03 Fabio Schittler Neves , Marc Timme

In networks of nonlinear oscillators, symmetries place hard constraints on the system that can be exploited to predict universal dynamical features and steady-states, providing a rare generic organizing principle for far-from-equilibrium…

斑图形成与孤子 · 物理学 2021-03-02 Ian Hunter , Michael M. Norton , Bolun Chen , Chris Simonetti , Maria Eleni Moustaka , Jonathan Touboul , Seth Fraden

According to the chemical reaction network theory, the topology of a certain class of chemical reaction networks, regardless of the kinetic details, sets a limit on the dynamical properties that a particular network can potentially admit;…

分子网络 · 定量生物学 2014-08-21 Jaewook Joo , Sanjeev Chauhan

We consider stochastic reaction networks modeled by continuous-time Markov chains. Such reaction networks often contain many reactions, potentially occurring at different time scales, and have unknown parameters (kinetic rates, total…

概率论 · 数学 2023-02-20 Linard Hoessly , Carsten Wiuf

This work addresses whether a reaction network, taken with mass-action kinetics, is multistationary, that is, admits more than one positive steady state in some stoichiometric compatibility class. We build on previous work on the effect…

分子网络 · 定量生物学 2019-08-27 AmirHosein Sadeghimanesh , Elisenda Feliu

The model of a memristor-based oscillator with cubic nonlinearity is studied. The considered system has infinitely many equilibrium points, which build a line of equilibria in the phase space. Numerical modeling of the dynamics is combined…

适应与自组织系统 · 物理学 2017-09-13 Ivan A. Korneev , Vladimir V. Semenov

Many reaction networks arising in applications are multistationary, that is, they have the capacity for more than one steady state; while some networks exhibit absolute concentration robustness (ACR), which means that some species…

动力系统 · 数学 2024-11-20 Nidhi Kaihnsa , Tung Nguyen , Anne Shiu

This work continues the analysis of complex dynamics in a class of bidimensional nonlinear hybrid dynamical systems with resets modeling neuronal voltage dynamics with adaptation and spike emission. We show that these models can generically…

Triadic interactions are special types of higher-order interactions that occur when regulator nodes modulate the interactions between other two or more nodes. In presence of triadic interactions, a percolation process occurring on a…

适应与自组织系统 · 物理学 2026-02-03 Hanlin Sun , Filippo Radicchi , Ginestra Bianconi

We consider local bifurcations of equilibria in dynamical systems arising from chemical reaction networks with mass action kinetics. In particular, given any mass action network admitting a local bifurcation of equilibria, assuming only a…

动力系统 · 数学 2025-05-20 Murad Banaji , Balázs Boros , Josef Hofbauer

Synchronization is an essential collective phenomenon in networks of interacting oscillators. Twisted states are rotating wave solutions in ring networks where the oscillator phases wrap around the circle in a linear fashion. Here, we…

动力系统 · 数学 2024-08-06 Christian Bick , Tobias Böhle , Oleh E. Omel'chenko

In the brain, coherent neuronal activities often appear simultaneously in multiple frequency bands, e.g., as combinations of alpha (8-12 Hz), beta (12.5-30 Hz), gamma (30-120 Hz) oscillations, among others. These rhythms are believed to…

神经元与认知 · 定量生物学 2023-04-26 Tianyi Wu , Yuhang Cai , Ruilin Zhang , Zhongyi Wang , Louis Tao , Zhuo-Cheng Xiao