相关论文: Tumor Growth with Nutrients: Regularity and Stabil…

In this paper we study a nonlinear free boundary problem on the radial growth of a two-layer solid tumor with a quiescent core. The tumor surface and its inner interface separating the proliferating cells and the quiescent cells are both…

Malignant cancers that lead to fatal outcomes for patients may remain dormant for very long periods of time. Although individual mechanisms such as cellular dormancy, angiogenic dormancy and immunosurveillance have been proposed, a…

In this contribution, the non-local, integro-partial differential system of equations proposed by Hillen et al. (Bull. Math. Biol. 75, 2013, no.1, 161-184) to account for the the tumor growth paradox (or the observation that some incomplete…

Mathematical models that describe the tumor growth process have been formulated by several authors in order to understand how cancer develops and to develop new treatment approaches. In this study, it is aimed to investigate the long-time…

In this work, we present a coupled 3D-1D model of solid tumor growth within a dynamically changing vascular network to facilitate realistic simulations of angiogenesis. Additionally, the model includes erosion of the extracellular matrix,…

We investigate noise-induced pattern formation in a model of cancer growth based on Michaelis-Menten kinetics, subject to additive and multiplicative noises. We analyse stability properties of the system and discuss the role of diffusion…

In this paper we study asymptotic behavior of solutions for a free boundary problem modeling the growth of tumors containing two species of cells: proliferating cells and quiescent cells. This tumor model was proposed by Pettet et al in…

Models of tissue growth are now well established, in particular in relation to their applications to cancer. They describe the dynamics of cells subject to motion resulting from a pressure gradient generated by the death and birth of cells,…

Cancer is a disease that takes millions of lives every year. Then, to propose treatments, avoid recurrence, and improve the patient's life quality, we need to analyze this disease from a biophysical perspective with a solid mathematical…

Stochastic resonance induced by external factor is considering to investigate the complex dynamics of tumor. The surrounding environment and the treatment effects on the tumor growth are considered as additive and multiplicative noises in…

A general theory of thermodynamically consistent biomechanical--biochemical growth in a body, considering mass addition in the bulk and at an incoherent interface, is developed. The incoherency arises due to incompatibility of growth and…

In this paper we study the growth of a tumor colony of multilayer type and focus on how the tumor grows from a near flat (when compared to the length of the tumor as, for instance, in the case of a bone tumor in a femur) initial colony. In…

For tumor growth, the morphological instability provides a mechanism for invasion via tumor fingering and fragmentation. This work considers the asymptotic stability of a free boundary tumor model with a periodic supply of external…

I consider how cell shape and environmental geometry affect the rate of nutrient capture and the consequent maximum growth rate of a cell, focusing on rod-like species like \textit{E.\ coli}. Simple modeling immediately implies that it is…

Tumor growth beyond a critical size relies on the development of a functional vascular network, which ensures adequate oxygen and nutrient supply. In this work, we present a modeling framework based on an optimization-based 3D-1D coupling…

We present a mathematical model describing the time development of a population of tumors subject to mutual angiogenic inhibitory signaling. Based on biophysical derivations, it describes organism-scale population dynamics under the…

We propose a new model of cancer growth based on nonextensive entropy. The evolution equation depends on the nonextensive parameter q. The exponential, the logistic, and the Gompertz growth laws are particular cases of the generalized…

We consider a diffuse interface model of tumor growth proposed by A.~Hawkins-Daruud et al. This model consists of the Cahn-Hilliard equation for the tumor cell fraction $\varphi$ nonlinearly coupled with a reaction-diffusion equation for…

In this paper, we consider an age-structured mechanical model for tumor growth. This model takes into account the life-cycle of tumor cells by including an age variable. The underlying process for tumor growth is the same as classical tumor…

In this paper, we study a distributed optimal control problem for a diffuse interface model for tumor growth. The model consists of a Cahn-Hilliard type equation for the phase field variable coupled to a reaction diffusion equation for the…