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This paper deals with the concept of equivalence between direct and indirect effects of a treatment on a response using two sets of intermediate variables and covariates. First, we provide criteria for testing whether two sets of variables…

统计理论 · 数学 2016-01-07 Manabu Kuroki

This paper develops a nonparametric model that represents how sequences of outcomes and treatment choices influence one another in a dynamic manner. In this setting, we are interested in identifying the average outcome for individuals in…

计量经济学 · 经济学 2019-01-16 Sukjin Han

This paper presents a general difference-in-differences framework for identifying path-dependent treatment effects when treatment histories are partially observed. We introduce a novel robust estimator that adjusts for missing histories…

计量经济学 · 经济学 2025-06-18 Akanksha Negi , Didier Nibbering

Interventional effects have been proposed as a solution to the unidentifiability of natural (in)direct effects under mediator-outcome confounders affected by the exposure. Such confounders are an intrinsic characteristic of studies with…

统计方法学 · 统计学 2022-03-30 Iván Díaz , Nicholas Williams , Kara E. Rudolph

Various methods have emerged for conducting mediation analyses with multiple correlated mediators, each with distinct strengths and limitations. However, a comparative evaluation of these methods is lacking, providing the motivation for…

应用统计 · 统计学 2024-06-25 Mary Appah , D. Leann Long , George Howard , Melissa J. Smith

Recently, the separable indirect effect (SIE) has gained attention due to its identifiability without requiring the untestable cross-world assumption necessary for the natural indirect effect (NIE). This article systematically compares the…

统计方法学 · 统计学 2025-07-08 Yan-Lin Chen , Sheng-Hsuan Lin

The goal of causal mediation analysis, often described within the potential outcomes framework, is to decompose the effect of an exposure on an outcome of interest along different causal pathways. Using the assumption of sequential…

统计方法学 · 统计学 2021-11-09 Lexi Rene , Antonio R. Linero , Elizabeth Slate

Mediation analysis seeks to understand the mechanism by which a treatment affects an outcome. Count or zero-inflated count outcome are common in many studies in which mediation analysis is of interest. For example, in dental studies,…

统计方法学 · 统计学 2016-07-12 Zijian Guo , Dylan S. Small , Stuart A. Gansky , Jing Cheng

When it comes to clinical survival trials, regulatory restrictions usually require the application of methods that solely utilize baseline covariates and the intention-to-treat principle. Thereby a lot of potentially useful information is…

统计方法学 · 统计学 2015-04-27 Susanne Strohmaier , Kjetil Røysland , Rune Hoff , Ørnulf Borgan , Terje Pedersen , Odd O. Aalen

This paper considers identifying and estimating the Average Treatment Effect on the Treated (ATT) when untreated potential outcomes are generated by an interactive fixed effects model. That is, in addition to time-period and individual…

计量经济学 · 经济学 2022-02-15 Brantly Callaway , Sonia Karami

Estimating individual-level treatment effect from observational data is a fundamental problem in causal inference and has attracted increasing attention in the fields of education, healthcare, and public policy.In this work, we concentrate…

机器学习 · 计算机科学 2025-07-10 Hui Meng , Keping Yang , Xuyu Peng , Bo Zheng

Pearl has provided the back door criterion, the front door criterion and the conditional instrumental variable (IV) method as identifiability criteria for total effects. In some situations, these three criteria can be applied to identifying…

统计方法学 · 统计学 2012-07-19 Manabu Kuroki , Zhihong Cai

The goal of personalized decision making is to map a unit's characteristics to an action tailored to maximize the expected outcome for that unit. Obtaining high-quality mappings of this type is the goal of the dynamic regime literature. In…

机器学习 · 计算机科学 2018-10-01 Razieh Nabi , Phyllis Kanki , Ilya Shpitser

The path-specific effect (PSE) is of primary interest in mediation analysis when multiple intermediate variables between treatment and outcome are observed, as it can isolate the specific effect through each mediator, thus mitigating…

统计方法学 · 统计学 2025-07-16 Jiawei Shan , Ting Wang , Wei Li , Chunrong Ai

Interventional effects for mediation analysis were proposed as a solution to the lack of identifiability of natural (in)direct effects in the presence of a mediator-outcome confounder affected by exposure. We present a theoretical and…

统计方法学 · 统计学 2020-11-17 Iván Díaz , Nima S. Hejazi , Kara E. Rudolph , Mark J. van der Laan

Causal mediation analysis can improve understanding of the mechanisms underlying epidemiologic associations. However, the utility of natural direct and indirect effect estimation has been limited by the assumption of no confounder of the…

应用统计 · 统计学 2020-06-16 Kara E. Rudolph , Oleg Sofrygin , Wenjing Zheng , Mark J. van der Laan

Understanding causal mechanisms in complex systems requires evaluating path-specific effects (PSEs) in multi-mediator models. Identification of PSEs traditionally relies on the demanding cross-world independence assumption. To relax this,…

统计方法学 · 统计学 2025-10-17 En-Yu Lai , Jih-Chang Yu , Yen-Tsung Huang

Comparative binary outcome data are of fundamental interest in statistics and are often pooled in meta-analyses. Here we examine the simplest case where for each study there are two patient groups and a binary event of interest, giving rise…

统计方法学 · 统计学 2018-06-12 Rose Baker , Dan Jackson

Mediation analyses are a statistical tool for testing the hypothesis about how the relationship between two variables may be direct or indirect via a third variable. Assessing statistical significance has been an area of active research;…

统计方法学 · 统计学 2021-06-07 Jason Steffener

This paper aims to provide practitioners of causal mediation analysis with a better understanding of estimation options. We take as inputs two familiar strategies (weighting and model-based prediction) and a simple way of combining them…