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We consider a diffuse interface model for tumor growth recently proposed in [Y. Chen, S.M. Wise, V.B. Shenoy, J.S. Lowengrub, A stable scheme for a nonlinear, multiphase tumor growth model with an elastic membrane, Int. J. Numer. Methods…

偏微分方程分析 · 数学 2015-07-29 Mimi Dai , Eduard Feireisl , Elisabetta Rocca , Giulio Schimperna , Maria Schonbek

We consider the problem of the long time dynamics for a diffuse interface model for tumor growth. The model describes the growth of a tumor surrounded by host tissues in the presence of a nutrient and consists in a Cahn-Hilliard-type…

偏微分方程分析 · 数学 2018-10-30 Alain Miranville , Elisabetta Rocca , Giulio Schimperna

We introduce a new diffuse interface model for tumour growth in the presence of a nutrient, in which we take into account mechanical effects and reversible tissue damage. The highly nonlinear PDEs system mainly consists of a Cahn-Hilliard…

偏微分方程分析 · 数学 2025-10-09 Giulia Cavalleri

In the present article the diffusion equation is used to model the spatio-temporal dynamics of a tumor, taking into account the heterogeneous of the medium. This approach makes it possible to take into account the complex geometric shape of…

生物物理 · 物理学 2023-02-07 Maxim V. Polyakov , Valeria V. Ten

Using formal asymptotic methods we derive a free boundary problem representing one of the simplest mathematical descriptions of the growth and death of a tumour or other biological tissue. The mathematical model takes the form of a closed…

组织与器官 · 定量生物学 2019-07-16 Joe Eyles , John F. King , Vanessa Styles

In this work, we consider a diffuse interface model for tumour growth in the presence of a nutrient which is consumed by the tumour. The system of equations consists of a Cahn--Hilliard equation with source terms for the tumour cells and a…

数值分析 · 数学 2022-05-09 Harald Garcke , Dennis Trautwein

This paper concerns multiphase models of tumor growth in interaction with a surrounding tissue, taking into account also the interplay with diffusible nutrients feeding the cells. Models specialize in nonlinear systems of possibly…

数学物理 · 物理学 2017-01-20 Andrea Tosin

We investigate the long-time dynamics and optimal control problem of a diffuse interface model that describes the growth of a tumor in presence of a nutrient and surrounded by host tissues. The state system consists of a Cahn-Hilliard type…

偏微分方程分析 · 数学 2023-07-28 Cecilia Cavaterra , Elisabetta Rocca , Hao Wu

We introduce here a new diffuse interface thermodynamically consistent non-isothermal model for tumor growth in presence of a nutrient in a domain $\Omega \subset \mathbb{R}^3$. In particular our system describes the growth of a tumor…

偏微分方程分析 · 数学 2022-12-19 Erica Ipocoana

In this paper we consider two diffuse interface models for tumor growth coupling a Cahn-Hilliard type equation for the tumor phase parameter to a reaction-diffusion type equation for the nutrient. The models are distinguished by the…

偏微分方程分析 · 数学 2024-07-31 Filippo Riva , Elisabetta Rocca

We consider a diffuse interface model for tumour growth consisting of a Cahn--Hilliard equation with source terms coupled to a reaction-diffusion equation. The coupled system of partial differential equations models a tumour growing in the…

偏微分方程分析 · 数学 2016-05-26 Harald Garcke , Kei Fong Lam

We study a non-local variant of a diffuse interface model proposed by Hawkins--Darrud et al. (2012) for tumour growth in the presence of a chemical species acting as nutrient. The system consists of a Cahn--Hilliard equation coupled to a…

偏微分方程分析 · 数学 2017-03-13 Sergio Frigeri , Kei Fong Lam , Elisabetta Rocca

We consider a diffuse interface model for tumor growth consisting of a Cahn--Hilliard equation with source terms coupled to a reaction-diffusion equation, which models a tumor growing in the presence of a nutrient species and surrounded by…

偏微分方程分析 · 数学 2017-05-04 Harald Garcke , Kei Fong Lam

We investigate the dynamics of a nonlinear model for tumor growth within a cellular medium. In this setting the "tumor" is viewed as a multiphase flow consisting of cancerous cells in either proliferating phase or quiescent phase and a…

偏微分方程分析 · 数学 2015-03-31 Donatella Donatelli , Konstantina Trivisa

Tumor growth beyond a critical size relies on the development of a functional vascular network, which ensures adequate oxygen and nutrient supply. In this work, we present a modeling framework based on an optimization-based 3D-1D coupling…

数值分析 · 数学 2026-04-01 Chiara Giverso , Denise Grappein , Stefano Scialò

We consider an optimal control problem for a diffuse interface model of tumor growth. The state equations couples a Cahn-Hilliard equation and a reaction-diffusion equation, which models the growth of a tumor in the presence of a nutrient…

最优化与控制 · 数学 2016-08-02 Harald Garcke , Kei-Fong Lam , Elisabetta Rocca

In this paper a macroscopic model of tumor cord growth is developed, relying on the mathematical theory of deformable porous media. Tumor is modeled as a saturated mixture of proliferating cells, extracellular fluid and extracellular…

数学物理 · 物理学 2010-11-09 Andrea Tosin

In this paper, we study a distributed optimal control problem for a diffuse interface model for tumor growth. The model consists of a Cahn-Hilliard type equation for the phase field variable coupled to a reaction diffusion equation for the…

最优化与控制 · 数学 2021-10-12 Matthias Ebenbeck , Patrik Knopf

It has been shown experimentally that contact interactions may influence the migration of cancer cells. Previous works have modelized this thanks to stochastic, discrete models (cellular automata) at the cell level. However, for the study…

细胞行为 · 定量生物学 2009-03-26 Christophe Deroulers , Marine Aubert , Mathilde Badoual , Basil Grammaticos

In this work we analyse a PDE-ODE problem modelling the evolution of a Glioblastoma, which includes an anisotropic nonlinear diffusion term with a diffusion velocity increasing with respect to vasculature. First, we prove the existence of…

偏微分方程分析 · 数学 2021-09-21 A. Fernández-Romero , F. Guillén-González , A. Suárez
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