相关论文: Recent advances on the non-coherent band surgery m…

Site-specific recombination on supercoiled circular DNA molecules can yield a variety of knots and catenanes. Twist knots are some of the most common conformations of these products and they can act as substrates for further rounds of…

Site-specific recombination on supercoiled circular DNA yields a variety of knotted or catenated products. We develop a model of this process, and give extensive experimental evidence that the assumptions of our model are reasonable. We…

We develop a topological model of site-specific recombination that applies to substrates which are the connected sum of two torus links of the form $T(2,n)\#T(2,m)$. Then we use our model to prove that all knots and links that can be…

We categorise coherent band (aka nullification) pathways between knots and 2-component links. Additionally, we characterise the minimal coherent band pathways (with intermediates) between any two knots or 2-component links with small…

We develop a model characterizing all possible knots and links arising from recombination starting with a twist knot substrate, extending previous work of Buck and Flapan. We show that all knot or link products fall into three…

The protein recombinase can change the knot type of circular DNA. The action of a recombinase converting one knot into another knot is normally mathematically modeled by band surgery. Band surgeries on a 2-bridge knot N((4mn-1)/(2m))…

We develop a topological model of knots and links arising from a single (or multiple processive) round(s) of recombination starting with an unknot, unlink, or (2,m)-torus knot or link substrate. We show that all knotted or linked products…

We consider a relation between two kinds of unknotting numbers defined by using a band surgery on unoriented knots; the band-unknotting number and H(2)-unknotting number, which we may characterize in terms of the first Betti number of…

Knots and links represent a fundamental motif of non-local connectivity that permeates the physical sciences from string theory to protein folds. While spectral braiding has been explored in two-band non-Hermitian models across various…

We describe Structured Random Binding (SRB), a minimal model of protein-protein interactions rooted in the statistical physics of disordered systems. In this model, nonspecific binding is a generic consequence of the interaction between…

We give necessary conditions of a surface-knot to be ribbon concordant to another, by introducing a new variant of the cocycle invariant of surface-knots in addition to using the invariant already known. We demonstrate that twist-spins of…

Circular permutation connects the N and C termini of a protein and concurrently cleaves elsewhere in the chain, providing an important mechanism for generating novel protein fold and functions. However, their in genomes is unknown because…

The knots-quivers correspondence states that various characteristics of a knot are encoded in the corresponding quiver and the moduli space of its representations. However, this correspondence is not a bijection: more than one quiver may be…

Knotted molecules occur naturally and are designed by scientists to gain special biological and material properties. Understanding and utilizing knotting require efficient methods to recognize and generate knotted structures, which are…

Relative self-linking and linking "numbers" for pairs of knots in oriented 3-manifolds are defined in terms of intersection invariants of immersed surfaces in 4-manifolds. The resulting concordance invariants generalize the usual…

A rational knot or link can be put into a standard alternating format which has horizontal and vertical twist sites (double helices). The number and type of these twist sites are determined by terms of next-to-highest $z$-degree in…

A splicing system is a formal model of a recombinant behaviour of sets of double stranded DNA molecules when acted on by restriction enzymes and ligase. In this survey we will concentrate on a specific behaviour of a type of splicing…

Intrinsically disordered proteins participate in many biological processes by folding upon binding with other proteins. However, coupled folding and binding processes are not well understood from an atomistic point of view. One of the main…

Splicing sites provide unique statistics in human genome due to their large number and reasonably complete annotation. Analyses of the cumulative SNPs distribution in splicing sites reveal a few interesting observations. While a degree of…

Cre-lox and other systems are used as genetic tools to control site-specific recombination (SSR) events in genomic DNA. If multiple recombination sites are organized in a compact cluster within the same genome, a series of random…