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Accurately modeling the relationship between perturbations, transcriptional responses, and phenotypic changes is essential for building an AI Virtual Cell (AIVC). However, existing methods typically constrained to modeling direct…

机器学习 · 计算机科学 2025-11-25 Rui Peng , Ziru Liu , Lingyuan Ye , Yuxing Lu , Boxin Shi , Jinzhuo Wang

In the small phylogeny problem we, are given a phylogenetic tree and gene orders of the extant species and our goal is to reconstruct all of the ancestral genomes so that the number of evolutionary operations is minimized. Algorithms for…

种群与进化 · 定量生物学 2015-03-17 Jakub Kováč , Broňa Brejová , Tomáš Vinař

Deep learning has proven itself as a successful set of models for learning useful semantic representations of data. These, however, are mostly implicitly learned as part of a classification task. In this paper we propose the triplet network…

机器学习 · 计算机科学 2018-12-05 Elad Hoffer , Nir Ailon

In this paper, we propose a novel method for the prior-art search task. We fine-tune SciBERT transformer model using Triplet Network approach, allowing us to represent each patent with a fixed-size vector. This also enables us to conduct…

信息检索 · 计算机科学 2022-07-26 Utku Umur Acikalin , Mucahid Kutlu

Network reconstruction lies at the heart of phylogenetic research. Two well studied classes of phylogenetic networks include tree-child networks and level-$k$ networks. In a tree-child network, every non-leaf node has a child that is a tree…

组合数学 · 数学 2019-07-23 Yukihiro Murakami , Leo van Iersel , Remie Janssen , Mark Jones , Vincent Moulton

A consensus tree is a phylogenetic tree that synthesizes a given collection of phylogenetic trees, all of which share the same leaf labels but may have different topologies, typically obtained through bootstrapping. Our research focuses on…

种群与进化 · 定量生物学 2025-08-13 Elio Torquet , Jesper Jansson , Nadia Tahiri

Background: Networks in different domains are characterized by similar global characteristics while differing in local structures. To further extend this concept, we investigated network regularities on a fine scale in order to examine the…

分子网络 · 定量生物学 2019-07-12 Alberto Calderone , Gianni Cesareni

We showed in this paper that similarity network can be used as an powerful tools to study the relationship of tRNA genes. We constructed a network of 3719 tRNA gene sequences using simplest alignment and studied its topology, degree…

分子网络 · 定量生物学 2009-09-29 Fangping Wei , Sheng Li , Hongru Ma

The reconstruction of phylogenetic networks is an important but challenging problem in phylogenetics and genome evolution, as the space of phylogenetic networks is vast and cannot be sampled well. One approach to the problem is to solve the…

种群与进化 · 定量生物学 2023-04-14 Louxin Zhang , Niloufar Abhari , Caroline Colijn , Yufeng Wu

The need for structures capable of accommodating complex evolutionary signals such as those found in, for example, wheat has fueled research into phylogenetic networks. Such structures generalize the standard phylogenetic tree model by also…

组合数学 · 数学 2015-11-30 Philippe Gambette , Katharina T. Huber , Guillaume E. Scholz

Inference of phylogenetic networks is of increasing interest in the genomic era. However, the extent to which phylogenetic networks are identifiable from various types of data remains poorly understood, despite its crucial role in…

种群与进化 · 定量生物学 2025-05-01 Elizabeth S. Allman , Cecile Ane , Hector Banos , John A. Rhodes

Compatibility of phylogenetic trees is the most important concept underlying widely-used methods for assessing the agreement of different phylogenetic trees with overlapping taxa and combining them into common supertrees to reveal the tree…

离散数学 · 计算机科学 2011-11-09 Merce Llabres , Jairo Rocha , Francesc Rossello , Gabriel Valiente

A binary phylogenetic network may or may not be obtainable from a tree by the addition of directed edges (arcs) between tree arcs. Here, we establish a precise and easily tested criterion (based on `2-SAT') that efficiently determines…

种群与进化 · 定量生物学 2015-05-25 Andrew R. Francis , Mike Steel

A contemporary and fundamental problem faced by many evolutionary biologists is how to puzzle together a collection $\mathcal P$ of partial trees (leaf-labelled trees whose leaves are bijectively labelled by species or, more generally,…

组合数学 · 数学 2007-09-04 S. Grünewald , K. T. Huber , Q. Wu

Due to the scarcity of large-scale in-the-wild triplet data and the improper use of masks, the performance of video virtual try-on models remains limited. In this paper, we first introduce **TripVVT-10K**, the largest and most diverse…

计算机视觉与模式识别 · 计算机科学 2026-05-01 Dingbao Shao , Song Wu , Shenyi Wang , Ye Wang , Ziheng Tang , Fei Liu , Jiang Lin , Xinyu Chen , Qian Wang , Ying Tai , Jian Yang , Zili Yi

We introduce "TriMap"; a dimensionality reduction technique based on triplet constraints, which preserves the global structure of the data better than the other commonly used methods such as t-SNE, LargeVis, and UMAP. To quantify the global…

机器学习 · 计算机科学 2022-03-29 Ehsan Amid , Manfred K. Warmuth

While every rooted binary phylogenetic tree is determined by its set of displayed rooted triples, such a result does not hold for an arbitrary rooted binary phylogenetic network. In particular, there exist two non-isomorphic rooted binary…

组合数学 · 数学 2021-04-13 Simone Linz , Charles Semple

As networking systems become increasingly complex, achieving disruptive innovation grows more challenging. At the same time, recent progress in Large Language Models (LLMs) has shown strong potential for scientific hypothesis formation and…

网络与互联网体系结构 · 计算机科学 2026-03-30 Mengrui Zhang , Bang Huang , Yunxin Xu , Haiying Huang , Luxi Zhao , Mochun Long , Qingyu Song , Qiao Xiang , Xue Liu , Jiwu Shu

Phylogenetic networks are notoriously difficult to reconstruct. Here we suggest that it can be useful to view unknown genetic distance along edges in phylogenetic networks as analogous to unknown resistance in electric circuits. This…

组合数学 · 数学 2020-10-01 Stefan Forcey , Drew Scalzo

Phylogenetic networks are increasingly used in evolutionary biology to represent the history of species that have undergone reticulate events such as horizontal gene transfer, hybrid speciation and recombination. One of the most fundamental…

种群与进化 · 定量生物学 2016-10-07 Philippe Gambette , Leo van Iersel , Steven Kelk , Fabio Pardi , Celine Scornavacca