前列腺癌进化分歧的成因
基因组学
2025-03-18 v1
摘要
癌症进展涉及遗传改变的顺序累积，这些改变共同塑造了肿瘤表型。在前列腺癌中，肿瘤可以遵循不同的进化轨迹从而导致不同的亚型，但这种分歧的成因仍不清楚。虽然因果推断可以阐明所涉及的因素，但由于存在未观测到的混杂因素以及因果方向上的模糊性，传统方法并不适用。在此，我们提出了一种规避这些问题的方法，并将其应用于 829 名前列腺癌患者的基因组数据。我们鉴定了几种驱动分歧的遗传改变，以及其他阻止这种转变、将肿瘤锁定在单一轨迹上的遗传改变。进一步分析表明，这些遗传改变可能相互引起，暗示存在一个加速分歧的正反馈回路。我们的研究结果为癌症亚型如何产生提供了见解，并为旨在监测前列腺癌进展的基因组监测策略奠定了基础。
引用
@article{arxiv.2503.13189,
title = {Causes of evolutionary divergence in prostate cancer},
author = {Emre Esenturk and Atef Sahli and Valeriia Haberland and Aleksandra Ziuboniewicz and Christopher Wirth and G. Steven Bova and Robert G Bristow and Mark N Brook and Benedikt Brors and Adam Butler and Géraldine Cancel-Tassin and Kevin CL Cheng and Colin S Cooper and Niall M Corcoran and Olivier Cussenot and Ros A Eeles and Francesco Favero and Clarissa Gerhauser and Abraham Gihawi and Etsehiwot G Girma and Vincent J Gnanapragasam and Andreas J Gruber and Anis Hamid and Vanessa M Hayes and Housheng Hansen He and Christopher M Hovens and Eddie Luidy Imada and G. Maria Jakobsdottir and Chol-hee Jung and Francesca Khani and Zsofia Kote-Jarai and Philippe Lamy and Gregory Leeman and Massimo Loda and Pavlo Lutsik and Luigi Marchionni and Ramyar Molania and Anthony T Papenfuss and Diogo Pellegrina and Bernard Pope and Lucio R Queiroz and Tobias Rausch and Jüri Reimand and Brian Robinson and Thorsten Schlomm and Karina D Sørensen and Sebastian Uhrig and Joachim Weischenfeldt and Yaobo Xu and Takafumi N Yamaguchi and Claudio Zanettini and Andy G Lynch and David C Wedge and Daniel S Brewer and Dan J Woodcock},
journal= {arXiv preprint arXiv:2503.13189},
year = {2025}
}