相关论文: Hopf bifurcation analysis of pathogen-immune inter…
Mathematical modeling of biological systems is crucial to effectively and efficiently developing treatments for medical conditions that plague humanity. Often, systems of ordinary differential equations are a traditional tool used to…
Singular Hopf bifurcation occurs in generic families of vector-fields with two slow variables and one fast variable. Normal forms for this bifurcation depend upon several parameters, and the dynamics displayed by the normal forms is…
In this paper, the dynamics of a modified Leslie-Gower predator-prey system with two delays and diffusion is considered. By calculating stability switching curves, the stability of positive equilibrium and the existence of Hopf bifurcation…
In the presented paper a family of angiogenesis models, that is a generalisation of Hahnfeldt et al. model is proposed. Considered family of models is a system of two differential equations with distributed time delays. The global existence…
This paper is devoted to the analysis of a mathematical model of blood cells production in the bone marrow (hematopoiesis). The model is a system of two age-structured partial differential equations. Integrating these equations over the…
Mathematical models of infectious disease transmission typically neglect within-host dynamics. Yet within-host dynamics - including pathogen replication, host immune responses, and interactions with microbiota - are crucial not only for…
We study how the interplay between the memory immune response and pathogen mutation affects epidemic dynamics in two related models. The first explicitly models pathogen mutation and individual memory immune responses, with contacted…
Gene regulatory networks, i.e. DNA segments in a cell which interact with each other indirectly through their RNA and protein products, lie at the heart of many important intracellular signal transduction processes. In this paper we analyse…
Neural field equations are integro-differential systems describing the macroscopic activity of spatially extended pieces of cortex. In such cortical assemblies, the propagation of information and the transmission machinery induce…
Infectious diseases are caused by pathogenic microorganisms and can spread through different ways. Mathematical models and computational simulation have been used extensively to investigate the transmission and spread of infectious…
The direct parametrisation method for invariant manifolds is adjusted to consider a varying parameter. More specifically, the case of systems experiencing a Hopf bifurcation in the parameter range of interest are investigated, and the…
Metabolic fluxes are the rates of life-sustaining chemical reactions within a cell and metabolites are the components. Determining the changes in these fluxes is crucial to understanding diseases with metabolic causes and consequences.…
The bifurcation diagram of a model nonlinear Langevin equation with delayed feedback is obtained numerically. We observe both direct and oscillatory bifurcations in different ranges of model parameters. Below threshold, the stationary…
A virus dynamics model with intracellular state-dependent delay and nonlinear infection rate of Beddington-DeAngelis functional response is studied. The technique of Lyapunov functionals is used to analyze stability of an interior infection…
We study bifurcations in networks of integrate-and-fire neurons with stochastic spike emission, focusing on the effects of the spatial and temporal structure of the synaptic interactions. Using a deterministic mean-field approximation of…
We will study a mathematical model of the human immunodeficiency virus (HIV) infection in the presence of combination therapy that includes within-host infectious dynamics. The deterministic model requires us to analyze asymptotic stability…
In this paper, we propose a mathematical model for HIV-1 infection with intracellular delay. The model examines a viral-therapy for controlling infections through recombining HIV-1 virus with a genetically modified virus. For this model,…
Dynamical systems across the sciences, from electrical circuits to ecological networks, undergo qualitative and often catastrophic changes in behavior, called bifurcations, when their underlying parameters cross a threshold. Existing…
We consider the standard neural field equation with an exponential temporal kernel. We analyze the time-independent (static) and time-dependent (dynamic) bifurcations of the equilibrium solution and the emerging spatiotemporal wave…
In this article, the phenomenon of delayed Hopf bifurcations (DHB) in reaction-diffusion PDEs is analyzed in the cubic Complex Ginzburg-Landau equation with a slowly-varying parameter. We use the classical asymptotic methods of stationary…