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In the framework of homogeneous susceptible-infected-recovered (SIR) models, we use a control theory approach to identify optimal pandemic mitigation strategies. We derive rather general conditions for reaching herd immunity while…

种群与进化 · 定量生物学 2021-07-05 Prakhar Godara , Stephan Herminghaus , Knut M. Heidemann

This paper analyses the optimal control of infectious disease propagation using a classic susceptible-infected-recovered (SIR) model characterised by permanent immunity and the absence of available vaccines. The control is performed over a…

This paper investigates a behavioral-feedback SIR model in which the infection rate adapts dynamically based on the fractions of susceptible and infected individuals. We introduce an invariant of motion and we characterize the peak of…

种群与进化 · 定量生物学 2025-09-17 Martina Alutto , Leonardo Cianfanelli , Giacomo Como , Fabio Fagnani , Francesca Parise

In this paper, we study an optimal control problem of a communicable disease in a prison population. In order to control the spread of the disease inside a prison, we consider an active case-finding strategy, consisting on screening a…

最优化与控制 · 数学 2020-11-06 Pedro Gajardo , Victor Riquelme , Diego Vicencio

We analyze an optimal control version of a simple SIRS epidemiology model. The policy maker can adopt policies to diminish the contact rate between infected and susceptible individuals, at a specific economic cost. The arrival of a vaccine…

种群与进化 · 定量生物学 2020-06-09 Evangelos Magirou

We study first order necessary conditions for an optimal control problem of a Susceptible-Infected-Recovered (SIR) model with limitations on the duration of the quarantine. The control is done by means of the reproduction number, i.e., the…

We consider a behavioral-feedback SIR epidemic model, in which the infection rate depends in feedback on the fractions of susceptible and infected agents, respectively. The considered model allows one to account for endogenous adaptation…

系统与控制 · 电气工程与系统科学 2026-02-11 Martina Alutto , Leonardo Cianfanelli , Giacomo Como , Fabio Fagnani , Francesca Parise

We analyze the optimal control of disease prevention and treatment in a basic SIS model. We develop a simple macroeconomic setup in which the social planner determines how to optimally intervene, through income taxation, in order to…

理论经济学 · 经济学 2019-10-09 Davide La Torre , Tufail Malik , Simone Marsiglio

During a pandemic, there are conflicting demands arising from public health and economic cost. Lockdowns are a common way of containing infections, but they adversely affect the economy. We study the question of how to minimise the economic…

种群与进化 · 定量生物学 2021-04-28 Joseph Samuel , Supurna Sinha

Without vaccines and treatments, societies must rely on non-pharmaceutical intervention strategies to control the spread of emerging diseases such as COVID-19. Though complete lockdown is epidemiologically effective, because it eliminates…

种群与进化 · 定量生物学 2021-01-08 Jason Hindes , Simone Bianco , Ira B. Schwartz

We study the impact of parameter estimation and state measurement errors on a control framework for optimally mitigating the spread of epidemics. We capture the epidemic spreading process using a susceptible-infected-removed (SIR) epidemic…

系统与控制 · 电气工程与系统科学 2024-08-08 Baike She , Lei Xin , Shreyas Sundaram , Philip E. Paré

Containment of epidemic outbreaks entails great societal and economic costs. Cost-effective containment strategies rely on efficiently identifying infected individuals, making the best possible use of the available testing resources.…

种群与进化 · 定量生物学 2020-12-01 Laura Natali , Saga Helgadottir , Onofrio M. Marago , Giovanni Volpe

In this research paper we modify a classical SIR model to better adapt to the dynamics of COVID-19, that is we propose the heterogeneous SQAIRD model where COVID-19 spreads over a population of economic agents, namely: the elderly, adults…

最优化与控制 · 数学 2021-05-19 Elena Gubar , Laura Policardo , Edgar J. Sanchez Carrera , Vladislav Taynitskiy

There are often multiple diseases with cross immunity competing for vaccination resources. Here we investigate the optimal vaccination program in a two-layer Susceptible-Infected-Removed (SIR) model, where two diseases with cross immunity…

种群与进化 · 定量生物学 2021-05-26 Yang Ye , Qingpeng Zhang , Zhidong Cao , Daniel Dajun Zeng

We propose and study a compartmental model for epidemiology with human behavioral effects. Specifically, our model incorporates governmental prevention measures aimed at lowering the disease infection rate, but we split the population into…

系统与控制 · 电气工程与系统科学 2026-02-16 Chloe Ngo , Christian Parkinson , Weinan Wang

In this paper, an SIR epidemic model with variable size of population is considered. We study optimal control problem for an SIR model with "vaccination" and "treatment" as controls. It is shown that an optimal control exists. We have…

最优化与控制 · 数学 2016-12-28 Olga Klimenkova

I estimate the Susceptible-Infected-Recovered (SIR) epidemic model for Coronavirus Disease 2019 (COVID-19). The transmission rate is heterogeneous across countries and far exceeds the recovery rate, which enables a fast spread. In the…

种群与进化 · 定量生物学 2020-03-27 Alexis Akira Toda

We consider the problem of the optimal allocation of vaccination and protection measures for the Susceptible-Infected-Recovered-Infected (SIRI) epidemiological model, which generalizes the classical Susceptible-Infected-Recovered (SIR) and…

最优化与控制 · 数学 2025-05-09 Urmee Maitra , Ashish R. Hota , Rohit Gupta , Alfred O. Hero

We consider the problem of controlling an SIR-model epidemic by temporarily reducing the rate of contact within a population. The control takes the form of a multiplicative reduction in the contact rate of infectious individuals. The…

最优化与控制 · 数学 2021-06-29 David I. Ketcheson

We study the classic Susceptible-Infected-Recovered (SIR) model for the spread of an infectious disease. In this stochastic process, there are two competing mechanism: infection and recovery. Susceptible individuals may contract the disease…

种群与进化 · 定量生物学 2012-05-08 E. Ben-Naim , P. L. Krapivsky
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