相关论文: Tumor-immune cell interactions by a fully paraboli…

Tumor-immune interactions are central to cancer progression and treatment outcomes. In this study, we present a stochastic agent-based model that integrates cellular heterogeneity, spatial cell-cell interactions, and drug resistance…

We present a spatial hybrid discrete-continuum modelling framework for the interaction dynamics between tumour cells and cytotoxic T cells, which play a pivotal role in the immune response against tumours. In this framework, tumour cells…

The Neumann problem in balls $\Omega\subset\mathbb{R}^n$, $n\in\{3,4\}$, for the chemotaxis system \begin{equation*} \left\{ \begin{array}{ll} u_t = \Delta u - \nabla \cdot (u\nabla v), \\[1mm] 0 = \Delta v - \mu^{(w)}(t) + w, \quad…

This paper deals with the quasilinear degenerate chemotaxis system with flux limitation \begin{align*} \begin{cases} u_t = \nabla\cdot\left(\dfrac{u^p \nabla u}{\sqrt{u^2 + |\nabla u|^2}} \right) -\chi \nabla\cdot\left( \dfrac{u^q\nabla…

A critical need exists for optimal therapeutic strategies for neuroblastoma, a prevalent and often fatal pediatric solid malignancy. To address the demand for quantitative models that can guide clinical decision-making, a novel mathematical…

We study the following Keller-Segel chemotaxis system with logistic source and nonlinear secretion: \begin{align*} u_t=\Delta u- \nabla\cdot(u\nabla v)+\kappa(|x|)u-\mu(|x|)u^p\quad\text{and}\quad 0=\Delta v-v+u^\gamma, \end{align*} where…

This paper deals with the higher dimension quasilinear parabolic-parabolic Keller-Segel system involving a source term of logistic type $ u_t=\nabla\cdot(\phi(u)\nabla u)-\chi\nabla\cdot(u\nabla v)+g(u)$, $\tau v_t=\Delta v-v+u$ in…

We prove existence of global weak solutions to the chemotaxis system $ u_t=\Delta u - \nabla\cdot (u\nabla v) +\kappa u -\mu u^2 $ $ v_t=\Delta v-v+u $ under homogeneous Neumann boundary conditions in a smooth bounded convex domain…

This work deals with a fully parabolic chemotaxis model with nonlinear production and chemoattractant. The problem is formulated on a bounded domain and, depending on a specific interplay between the coefficients associated to such…

In this paper, we study a semilinear parabolic PDE system which describes the interaction of normal cells, tumor cells, immune cells, with a chemotherapeutic drug. The model extends the previous model with incorporating strong Allee affects…

This paper deals with the quasilinear fully parabolic attraction-repulsion chemotaxis system \begin{align*} u_t=\nabla \cdot (D(u)\nabla u) -\nabla \cdot (G(u)\chi(v)\nabla v) +\nabla\cdot(H(u)\xi(w)\nabla w), \quad v_t=d_1\Delta v+\alpha…

In this paper, we study the spreading speeds and traveling wave solutions of the PDE $$ \begin{cases} u_{t}= \Delta u-\chi \nabla \cdot (u \nabla v) + u(1-u),\ \ x\in\mathbb{R}^N 0=\Delta v-v+u, \ \ x\in\mathbb{R}^N, \end{cases} $$ where…

We consider a parabolic-elliptic Keller-Segel system with spatially dependent diffusion sensitivity \begin{eqnarray*} \left\{ \begin{array}{l} u_t = \nabla \cdot (|x|^\beta \nabla u) - \nabla \cdot (u\nabla v), \\[1mm] 0 = \Delta v - \mu +…

\indent In this paper, we study a class of parabolic-elliptic Keller-Segel systems with diffusion sensitivity dependent on spatial position, given by type \begin{equation} \left\{ \begin{array}{ll} u_{t} = \bigtriangledown\cdot(|x|^{\beta}…

The evolutionary and ecological dynamics of tumors under immune responses and therapeutic interventions pose major challenges to long-term treatment success. Although treatment may initially achieve short-term disease control, resistant…

This work is the second of the series of three papers devoted to the study of asymptotic dynamics in the chemotaxis system with space and time dependent logistic source,$$\partial_tu=\Delta u-\chi\nabla\cdot(u\nabla…

We consider the potentially degenerate haptotaxis system \begin{equation*} \left\{ \begin{aligned} u_t &= \nabla \cdot (\mathbb{D} \nabla u + u \nabla \cdot \mathbb{D}) - \chi \nabla \cdot (u\mathbb{D}\nabla w) + \mu u(1-u^{r- 1}), \\ w_t…

In a ball $\Omega\subset R^n$ with arbitrary $n\ge 1$, the chemotaxis-consumption system \[ \left\{ \begin{array}{l} u_t = \nabla \cdot \big(D(u)\nabla u\big) - \nabla \cdot (u\nabla v), \\[1mm] 0 = \Delta v - uv, \end{array} \right. \] is…

This paper deals with the fully parabolic attraction-repulsion chemotaxis system \begin{align*} u_t=\Delta u-\chi\nabla \cdot (u\nabla v)+\xi \nabla\cdot(u \nabla w), \quad v_t=\Delta v-v+u, \quad w_t=\Delta w-w+u, \quad x \in \Omega,\ t>0…

This work considers a model for oncolytic virotherapy, as given by the reaction-diffusion-taxis system $$ \left\{ \begin{array}{l} u_t = \Delta u - \nabla \cdot (u\nabla v)-\rho uz, \\[1mm] v_t = - (u+w)v, \\[1mm] w_t = D_w \Delta w - w +…