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Sorting cells based on their mechanical properties is essential for applications in disease diagnostics, cell therapy, and biomedical research. Deterministic Lateral Displacement (DLD) devices provide a label-free method for achieving such…

定量方法 · 定量生物学 2025-12-08 Khayrul Islam , Mehedi Hasan , Yaling Liu

Several problems in stochastic analysis are defined through their geometry, and preserving that geometric structure is essential to generating meaningful predictions. Nevertheless, how to design principled deep learning (DL) models capable…

机器学习 · 计算机科学 2023-03-10 Beatrice Acciaio , Anastasis Kratsios , Gudmund Pammer

By incorporating physical consistency as inductive bias, deep neural networks display increased generalization capabilities and data efficiency in learning nonlinear dynamic models. However, the complexity of these models generally…

机器学习 · 计算机科学 2025-03-03 Katharina Friedl , Noémie Jaquier , Jens Lundell , Tamim Asfour , Danica Kragic

We investigate the sensitivity of reduced order models (ROMs) to training data resolution as well as sampling rate. In particular, we consider proper orthogonal decomposition (POD), coupled with Galerkin projection (POD-GP), as an intrusive…

流体动力学 · 物理学 2020-07-15 Shady E. Ahmed , Omer San , Diana A. Bistrian , Ionel M. Navon

Deterministic Lateral Displacement (DLD) devices enable liquid biopsy for cancer detection by separating circulating tumor cells (CTCs) from blood samples based on size, but designing these microfluidic devices requires computationally…

机器学习 · 计算机科学 2025-11-25 Andrew Lee , Mahir Mobarrat , Xiaolin Chen

Physics-aware deep learning (PADL) has gained popularity for use in complex spatiotemporal dynamics (field evolution) simulations, such as those that arise frequently in computational modeling of energetic materials (EM). Here, we show that…

Reduced Order Models (ROMs) have gained a great attention by the scientific community in the last years thanks to their capabilities of significantly reducing the computational cost of the numerical simulations, which is a crucial objective…

数值分析 · 数学 2024-06-05 Guglielmo Padula , Michele Girfoglio , Gianluigi Rozza

Surrogate models for the rapid inference of nonlinear boundary value problems in mechanics are helpful in a broad range of engineering applications. However, effective surrogate modeling of applications involving the contact of deformable…

计算工程、金融与科学 · 计算机科学 2025-07-21 Vijay K. Dubey , Collin E. Haese , Osman Gültekin , David Dalton , Manuel K. Rausch , Jan N. Fuhg

Reduced order modeling (ROM) provides an efficient framework to compute solutions of parametric problems. Basically, it exploits a set of precomputed high-fidelity solutions --- computed for properly chosen parameters, using a full-order…

数值分析 · 数学 2019-11-19 Nicola Demo , Marco Tezzele , Gianluigi Rozza

Generally, reduced order models of fluid flows are obtained by projecting the Navier-Stokes equations onto a reduced subspace spanned by vector functions that carry the meaningful information of the dynamics. A common method to generate…

流体动力学 · 物理学 2023-09-22 M. Oulghelou , A. Ammar , R. Ayoub

This work presents a nonintrusive physics-preserving method to learn reduced-order models (ROMs) of Lagrangian systems, which includes nonlinear wave equations. Existing intrusive projection-based model reduction approaches construct…

数值分析 · 数学 2024-04-05 Harsh Sharma , Boris Kramer

Multiple model reduction techniques have been proposed to tackle linear and non linear problems. Intrusive model order reduction techniques exhibit high accuracy levels, however, they are rarely used as a standalone industrial tool, because…

计算工程、金融与科学 · 计算机科学 2025-04-10 Mikhael Tannous , Chady Ghnatios , Eivind Fonn , Trond Kvamsdal , Francisco Chinesta

Geometric deep learning (GDL), which is based on neural network architectures that incorporate and process symmetry information, has emerged as a recent paradigm in artificial intelligence. GDL bears particular promise in molecular modeling…

化学物理 · 物理学 2022-01-03 Kenneth Atz , Francesca Grisoni , Gisbert Schneider

We propose a computationally efficient framework to treat nonlinear partial differential equations having bifurcating solutions as one or more physical control parameters are varied. Our focus is on steady bifurcations. Plotting a…

数值分析 · 数学 2020-06-11 Federico Pichi , Annalisa Quaini , Gianluigi Rozza

This paper presents the first application of the direct parametrisation method for invariant manifolds to a fully coupled multiphysics problem involving the nonlinear vibrations of deformable structures subjected to an electrostatic field.…

数值分析 · 数学 2023-12-25 Attilio Frangi , Alessio Colombo , Alessandra Vizzaccaro , Cyril Touzé

We propose a new class of deep reinforcement learning (RL) algorithms that model latent representations in hyperbolic space. Sequential decision-making requires reasoning about the possible future consequences of current behavior.…

机器学习 · 计算机科学 2022-10-05 Edoardo Cetin , Benjamin Chamberlain , Michael Bronstein , Jonathan J Hunt

Graph Neural Networks usually rely on the assumption that the graph topology is available to the network as well as optimal for the downstream task. Latent graph inference allows models to dynamically learn the intrinsic graph structure of…

机器学习 · 计算机科学 2023-06-28 Haitz Sáez de Ocáriz Borde , Anees Kazi , Federico Barbero , Pietro Liò

Inspired by the Equation-Free paradigm, we propose an ``embed-learn-lift'' framework for constructing minimal-dimensional surrogate ROMs for the numerical analysis of high-fidelity Navier-Stokes simulations, even in the presence of…

Surrogate modeling for complex physical systems typically faces a trade-off between data-fitting accuracy and physical consistency. Physics-consistent approaches typically treat physical laws as soft constraints within the loss function, a…

机器学习 · 计算机科学 2026-01-30 José Afonso , Pedro Viegas , Rodrigo Ventura , Vasco Guerra

Kinetic equations are crucial for modeling non-equilibrium phenomena, but their computational complexity is a challenge. This paper presents a data-driven approach using reduced order models (ROM) to efficiently model non-equilibrium flows…

流体动力学 · 物理学 2023-10-09 Julian Koellermeier , Philipp Krah , Julius Reiss , Zachary Schellin