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Severe acute respiratory syndrome coronavirus two (SARS-CoV-2), the virus responsible for the coronavirus disease 2019 (COVID-19) pandemic, represents an unprecedented global health challenge. Consequently, a large amount of research into…

We present a differential equations model in which contagious disease transmission is affected by contagious fear of the disease and contagious fear of the control, in this case vaccine. The three contagions are coupled. The two fears…

种群与进化 · 定量生物学 2021-02-23 Joshua M. Epstein , Erez Hatna , Jennifer Crodelle

The increasing spread of COVID-19, caused by the virus SARS-CoV-2, raises concerns about the extent to which mutations have occurred across the viral genome. We present a partial replication of an earlier 2021 study by Wang, R. et al. that…

基因组学 · 定量生物学 2021-12-28 William Svoboda , Brendan McManamon , Sara Schwartz

Susceptible-Exposed-Infectious-Recovered (SEIR) models with inter-individual variation in susceptibility or exposure to infection were proposed early in the COVID-19 pandemic as a potential element of the mathematical/statistical toolset…

应用统计 · 统计学 2025-10-28 Ibrahim Mohammed , Chris Robertson , M. Gabriela M. Gomes

The Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2), or Covid-19, burst into a pandemic in the beginning of 2020. An unprecedented worldwide effort involving academic institutions, regulatory agencies and industry is facing…

Recurrent waves which are often observed during long pandemics typically form as a result of several interrelated dynamics including public health interventions, population mobility and behaviour, varying disease transmissibility due to…

Susceptibility governs the dynamics of contagion. The classical SIR model is one of the simplest compartmental models of contagion spread, assuming a single shared susceptibility level. However, variation in susceptibility over a population…

种群与进化 · 定量生物学 2020-09-22 Christopher Rose , Andrew J. Medford , C. Franklin Goldsmith , Tejs Vegge , Joshua Weitz , Andrew A. Peterson

We recently described a dynamic causal model of a COVID-19 outbreak within a single region. Here, we combine several of these (epidemic) models to create a (pandemic) model of viral spread among regions. Our focus is on a second wave of new…

National responses to the Covid-19 pandemic varied markedly across countries, from business-as-usual to complete shutdowns. Policies aimed at disrupting the viral transmission cycle and preventing the healthcare system from being…

种群与进化 · 定量生物学 2021-10-27 Arash Saeidpour , Pejman Rohani

Since the recent introduction of several viable vaccines for SARS-CoV-2, vaccination uptake has become the key factor that will determine our success in containing the COVID-19 pandemic. We argue that game theory and social network models…

Currently, due to the COVID-19 pandemic the public life in most European countries stopped almost completely due to measures against the spread of the virus. Efforts to limit the number of new infections are threatened by the advent of new…

种群与进化 · 定量生物学 2021-02-24 Thomas Götz , Wolfgang Bock , Robert Rockenfeller , Moritz Schäfer

The Covid-19 outbreak of 2020 has required many governments to develop and adopt mathematical-statistical models of the pandemic for policy and planning purposes. To this end, this work provides a tutorial on building a compartmental model…

应用统计 · 统计学 2023-09-13 Elizabeth B Amona , Ryad A Ghanam , Edward L Boone , Indranil Sahoo , Laith J Abu-Raddad

The emergence of new variants of SARS-CoV-2 is a major concern given their potential impact on the transmissibility and pathogenicity of the virus as well as the efficacy of therapeutic interventions. Here, we predict the mutability of all…

基因组学 · 定量生物学 2022-05-11 Juan Rodriguez-Rivas , Giancarlo Croce , Maureen Muscat , Martin Weigt

Currently, the world seeks to find appropriate mitigation techniques to control and prevent the spread of the new SARS-CoV-2. In our paper herein, we present a peculiar Multi-Task Learning framework that jointly predicts the effect of…

机器学习 · 计算机科学 2021-08-24 Bonaventure Chidube Molokwu , Shaon Bhatta Shuvo , Ziad Kobti , Anne Snowdon

During the COVID-19 pandemic, governments faced the challenge of managing population behavior to prevent their healthcare systems from collapsing. Sweden adopted a strategy centered on voluntary sanitary recommendations while Belgium…

计量经济学 · 经济学 2024-01-17 Tijs W. Alleman , Jan M. Baetens

Classically, endemic infectious diseases are expected to display relatively stable, predictable infection dynamics. Accordingly, basic disease models such as the susceptible-infected-recovered-susceptible model display stable endemic states…

Pathogens drive changes in host immune systems that in turn exert pressure for pathogens to evolve. Quantifying and understanding this constant coevolutionary process has clear practical global health implications. Yet its relatively easier…

种群与进化 · 定量生物学 2023-06-09 Thierry Mora , Aleksandra Walczak

The COVID-19 pandemic caused by the SARS-CoV-2 virus has spread rapidly worldwide, leading to a global outbreak. Most governments, enterprises, and scientific research institutions are participating in the COVID-19 struggle to curb the…

定量方法 · 定量生物学 2021-03-12 Jianguo Chen , Kenli Li , Zhaolei Zhang , Keqin Li , Philip S. Yu

Within the context that Greece promises a success story in the fight against the disease, this paper proposes a novel method to study the evolution of the Greek COVID-19 infection-curve in relation to the anti-COVID-19 policies applied to…

物理与社会 · 物理学 2021-01-28 Dimitrios Tsiotas , Lykourgos Magafas

COVID-19 is an infection caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome coronavirus 2), which has caused a global outbreak. Current research efforts are focused on the understanding of the molecular mechanisms involved in…