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Real-world multi-agent systems are often dynamic and continuous, where the agents co-evolve and undergo changes in their trajectories and interactions over time. For example, the COVID-19 transmission in the U.S. can be viewed as a…

机器学习 · 计算机科学 2024-03-04 Zijie Huang , Jeehyun Hwang , Junkai Zhang , Jinwoo Baik , Weitong Zhang , Dominik Wodarz , Yizhou Sun , Quanquan Gu , Wei Wang

COVID-19 is a devastating respiratory and inflammatory illness caused by a new coronavirus that is rapidly spreading throughout the human population. Over the past 6 months, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the…

The adaptive immune system engages in an arms race with evolving viruses, trying to generate new responses to viral strains that continually move away from the set of variants that have already elicited a functional immune response. In…

种群与进化 · 定量生物学 2024-06-04 David A. Kessler , Herbert Levine

Although lessons have been learned from previous severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) outbreaks, the rapid evolution of the viruses means that future outbreaks of a much larger scale are…

种群与进化 · 定量生物学 2022-05-12 Zi Hian Tan , Kian Yan Yong , Jian-Jun Shu

A genome, composed of a precisely ordered sequence of four nucleotides (ATCG), encompasses a multitude of specific genome features like AAA motif. Mutations occurring within a genome disrupt the sequential order and composition of these…

其他定量生物学 · 定量生物学 2024-03-26 Anyou Wang

We investigate two representation alternatives for the controllers of teams of cyber agents. We combine these controller representations with different evolutionary algorithms, one of which introduces a novel LLM-supported mutation…

神经与进化计算 · 计算机科学 2025-07-09 Erik Hemberg , Eric Liu , Lucille Fuller , Stephen Moskal , Una-May O'Reilly

The widespread availability of large amounts of genomic data on the SARS-CoV-2 virus, as a result of the COVID-19 pandemic, has created an opportunity for researchers to analyze the disease at a level of detail unlike any virus before it.…

机器学习 · 计算机科学 2021-10-20 Zahra Tayebi , Sarwan Ali , Murray Patterson

In 2022 new subvariants of Coronavirus appeared in South Africa, and spread rapidly to other parts of the world. The effects of selective evolution on increasing the already high contagiousness of CoV19 up to Omicron were previously…

其他定量生物学 · 定量生物学 2022-08-11 J. C. Phillips

The world has faced the devastating outbreak of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), or COVID-19, in 2020. Research in the subject matter was fast-tracked to such a point that scientists were struggling to keep up…

信息检索 · 计算机科学 2020-09-03 Maksim Ekin Eren , Nick Solovyev , Edward Raff , Charles Nicholas , Ben Johnson

In December 2019, the first patients in Wuhan, China were diagnosed with a primary atypical pneumonia, which showed to be unknown and contagious. Since then, known as COVID-19 disease, the responsible viral pathogen, SARS-CoV-2, has spread…

种群与进化 · 定量生物学 2024-01-30 Philipp Heider

A key scientific challenge during the outbreak of novel infectious diseases is to predict how the course of the epidemic changes under different countermeasures that limit interaction in the population. Most epidemiological models do not…

Severe acute respiratory disease SARS-CoV-2 has had a found impact on public health systems and healthcare emergency response especially with respect to making decisions on the most effective measures to be taken at any given time. As…

机器学习 · 计算机科学 2023-09-19 Charithea Stylianides , Kleanthis Malialis , Panayiotis Kolios

The SARS-CoV-2 pandemic has created a global race for a cure. One approach focuses on designing a novel variant of the human angiotensin-converting enzyme 2 (ACE2) that binds more tightly to the SARS-CoV-2 spike protein and diverts it from…

Computational models for the simulation of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic evolution would be extremely useful to support authorities in designing healthcare policies and lockdown measures to…

种群与进化 · 定量生物学 2020-04-20 Marco Paggi

Despite of the fast development of highly effective vaccines to control the current COVID$-$19 pandemic, the unequal distribution and availability of these vaccines worldwide and the number of people infected in the world lead to the…

More infectious virus variants can arise from rapid mutations in their proteins, creating new infection waves. These variants can evade one's immune system and infect vaccinated individuals, lowering vaccine efficacy. Hence, to improve…

机器学习 · 计算机科学 2022-05-31 Glenda Tan Hui En , Koay Tze Erhn , Shen Bingquan

Very recently the new pathogen severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified and the coronavirus disease 2019 (COVID-19) declared a pandemic by the World Health Organization. The pandemic has a number of…

In the past several months, COVID-19 has spread over the globe and caused severe damage to the people and the society. In the context of this severe situation, an effective drug discovery method to generate potential drugs is extremely…

机器学习 · 计算机科学 2021-04-26 Tianyue Cheng , Tianchi Fan , Landi Wang

Changes in human behavior are increasingly recognized as a major determinant of epidemic dynamics. Although collective activity can be modified through imposed measures to control epidemic progression, spontaneous changes can also arise as…

种群与进化 · 定量生物学 2021-05-25 Susanna Manrubia , Damián H. Zanette

The SARS-CoV-2 virus and COVID-19 disease have posed unprecedented and overwhelming demand, challenges and opportunities to domain, model and data driven modeling. This paper provides a comprehensive review of the challenges, tasks,…

计算机与社会 · 计算机科学 2021-08-05 Longbing Cao , Qing Liu