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Neurons in the nervous system are submitted to distinct sources of noise, such as ionic-channel and synaptic noise, which introduces variability in their responses to repeated presentations of identical stimuli. This motivates the use of…

The purpose of this paper is to analyze the mechanism for the interplay of deterministic and stochastic models for contagious diseases. Deterministic models for contagious diseases are prone to predict global stability. Small natural birth…

种群与进化 · 定量生物学 2022-06-17 Torsten Lindström

This work aims at providing a new model for time series classification based on learning from just one example. We assume that time series can be well characterized as a parametric random process, a sort of Hidden semi-Markov Model…

We generalize the Kuramoto model of coupled oscillators to allow time-delayed interactions. New phenomena include bistability between synchronized and incoherent states, and unsteady solutions with time-dependent order parameters. We derive…

chao-dyn · 物理学 2009-10-31 M. K. Stephen Yeung , Steven H. Strogatz

We propose a stochastic individual-based model of the progression of atrial fibrillation (AF). The model operates at patient level over a lifetime and is based on elements of the physiology and biophysics of AF, making contact with existing…

种群与进化 · 定量生物学 2015-07-29 Eugene TY Chang , Yen Ting Lin , Tobias Galla , Richard H Clayton , Julie Eatock

A number of coupling strategies are presented for stochastically modeled biochemical processes with time-dependent parameters. In particular, the stacked coupling is introduced and is shown via a number of examples to provide an…

数值分析 · 数学 2018-04-04 David F. Anderson , Chaojie Yuan

We have developed and implemented a numerical evolution scheme for a class of stochastic problems in which the temporal evolution occurs on widely-separated time scales, and for which the slow evolution can be described in terms of a small…

计算物理 · 物理学 2009-09-29 S. Setayeshgar , C. W. Gear , H. G. Othmer , I. G. Kevrekidis

Traditional mediation analysis typically examines the relations among an intervention, a time-invariant mediator, and a time-invariant outcome variable. Although there may be a direct effect of the intervention on the outcome, there is a…

应用统计 · 统计学 2020-08-28 Xizhen Cai , Donna L. Coffman , Megan E. Piper , Runze Li

What happens when the paradigmatic Kuramoto model involving interacting oscillators of distributed natural frequencies and showing spontaneous collective synchronization in the stationary state is subject to random and repeated…

适应与自组织系统 · 物理学 2022-07-08 Mrinal Sarkar , Shamik Gupta

We propose an integrated electromechanical model of the human heart, with focus on the left ventricle, wherein biophysically detailed models describe the different physical phenomena concurring to the cardiac function. We model the…

In a computational study we reveal a novel dynamical instability of excitation waves in the heartmuscle. The instability manifests itself as gradual local increase in the duration of the actionpotential which causes formation and…

生物物理 · 物理学 2019-08-15 L. D. Weise , A. V. Panfilov

We examine a modification of the Kuramoto model for phase oscillators coupled on a network. Here, two populations of oscillators are considered, each with different network topologies, internal and cross-network couplings and frequencies.…

动力系统 · 数学 2016-02-17 A. C. Kalloniatis , M. L. Zuparic

A new collective behavior of resonant synchronization is discovered and the ability to retrieve information from brain memory is proposed based on this mechanism. We use modified Kuramoto phase oscillator to simulate the dynamics of a…

适应与自组织系统 · 物理学 2018-09-06 Lin Zhang , Xv Li , Tingting Xue

We examine analytically and numerically a variant of the stochastic Kuramoto model for phase oscillators coupled on a general network. Two populations of phased oscillators are considered, labelled `Blue' and `Red', each with their…

适应与自组织系统 · 物理学 2017-02-01 A. B. Holder , M. L. Zuparic , A. C. Kalloniatis

We propose and analyse the properties of a new class of models for the electromechanics of cardiac tissue. The set of governing equations consists of nonlinear elasticity using a viscoelastic and orthotropic exponential constitutive law…

Experiments that discuss influence of noise to H. Seidel and H. Herzel dynamics model of human cardiovascular system are presented. Noise is introduced by considering stochastic delays in response to the sympathetic system. It appears that…

组织与器官 · 定量生物学 2007-05-23 Aleksandra Dudkowska , Danuta Makowiec

A two-component model is developed that consists of a discrete loop of cardiac cells that circulates action potentials together with a cardiac pacing mechanism. Physiological properties of cells such as restitutions of refractoriness and of…

适应与自组织系统 · 物理学 2014-01-16 H. Sedaghat , M. A. Wood , J. W. Cain , C-K. Cheng , C. M. Baumgarten , D. M. Chan

Collective oscillation of cells in a population has been reported under diverse biological contexts and with vastly different molecular constructs. Could there be common principles similar to those that govern spontaneous oscillation in…

细胞行为 · 定量生物学 2019-07-08 Shou-Wen Wang , Lei-Han Tang

The interplay of seasonality, the system's nonlinearities and intrinsic stochasticity is studied for a seasonally forced susceptible-exposed-infective-recovered stochastic model. The model is explored in the parameter region that…

生物物理 · 物理学 2010-10-19 Ganna Rozhnova , Ana Nunes

We study synchronization phenomenon in a self-correcting population of noisy phase oscillators with randomly distributed natural frequencies. In our model each oscillator stochastically switches its phase to the ensemble-averaged value…

适应与自组织系统 · 物理学 2016-03-17 Sergey Belan