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We consider the inverse problem of parameter estimation in a diffuse interface model for tumour growth. The model consists of a fourth-order Cahn-Hilliard system and contains three phenomenological parameters: the tumour proliferation rate,…

数值分析 · 数学 2019-05-10 Christian Kahle , Kei Fong Lam , Jonas Latz , Elisabeth Ullmann

The purpose of this paper is to derive anisotropic mean curvature flow as the limit of the anisotropic Allen-Cahn equation. We rely on distributional solution concepts for both the diffuse and sharp interface models, and prove convergence…

偏微分方程分析 · 数学 2022-12-23 Tim Laux , Kerrek Stinson , Clemens Ullrich

The paper deals with a phase field system of Cahn-Hilliard type. For positive viscosity coefficients, the authors prove an existence and uniqueness result and study the long time behavior of the solution by assuming the nonlinearities to be…

偏微分方程分析 · 数学 2014-03-24 Pierluigi Colli , Gianni Gilardi , Danielle Hilhorst

In this paper we perform an asymptotic analysis for two different vanishing viscosity coefficients occurring in a phase field system of Cahn-Hilliard type that was recently introduced in order to approximate a tumor growth model. In…

偏微分方程分析 · 数学 2015-02-02 Pierluigi Colli , Gianni Gilardi , Elisabetta Rocca , Juergen Sprekels

We use a diffuse interface method for solving Poisson's equation with a Dirichlet condition on an embedded curved interface. The resulting diffuse interface problem is identified as a standard Dirichlet problem on approximating regular…

数值分析 · 数学 2015-11-23 Matthias Schlottbom

This paper concerns multiphase models of tumor growth in interaction with a surrounding tissue, taking into account also the interplay with diffusible nutrients feeding the cells. Models specialize in nonlinear systems of possibly…

数学物理 · 物理学 2017-01-20 Andrea Tosin

We introduce a diffuse interface model describing the evolution of a mixture of two different viscous incompressible fluids of equal density. The main novelty of the present contribution consists in the fact that the effects of temperature…

偏微分方程分析 · 数学 2014-01-15 Michela Eleuteri , Elisabetta Rocca , Giulio Schimperna

We construct a diffuse-interface model of two-phase solidification that quantitatively reproduces the classic free boundary problem on solid-liquid interfaces in the thin-interface limit. Convergence tests and comparisons with boundary…

材料科学 · 物理学 2009-11-10 R. Folch , M. Plapp

In this paper, we study a distributed optimal control problem for a diffuse interface model for tumor growth. The model consists of a Cahn-Hilliard type equation for the phase field variable coupled to a reaction diffusion equation for the…

最优化与控制 · 数学 2021-10-12 Matthias Ebenbeck , Patrik Knopf

This paper is concerned with a phase field system of Cahn-Hilliard type that is related to a tumor growth model and consists of three equations in terms of the variables order parameter, chemical potential and nutrient concentration. This…

偏微分方程分析 · 数学 2015-03-04 Pierluigi Colli , Gianni Gilardi , Elisabetta Rocca , Jürgen Sprekels

We study an evolutionary system of Cahn-Hilliard-Darcy type including mass source and transport effects. The system may arise in a number of physical situations related to phase separation phenomena with convection, with the main and most…

偏微分方程分析 · 数学 2022-02-24 Giulio Schimperna

We develop a computational method for simulating the nonlinear dynamics of an elastic tumor-host interface. This work is motivated by the recent linear stability analysis of a two-phase tumor model with an elastic membrane interface in 2D.…

数值分析 · 数学 2019-12-12 Min-Jhe Lu , Chun Liu , Shuwang Li

We consider the sharp interface limit of a convective Allen-Cahn equation, which can be part of a Navier-Stokes/Allen-Cahn system, for different scalings of the mobility $m_\varepsilon=m_0\varepsilon^\theta$ as $\varepsilon\to 0$. In the…

偏微分方程分析 · 数学 2021-02-22 Helmut Abels

We analyze a system of cross-diffusion equations that models the growth of an avascular-tumor spheroid. The model incorporates two nonlinear diffusion effects, degeneracy type and super diffusion. We prove the global existence of weak…

偏微分方程分析 · 数学 2022-10-14 Samiha Belmor

In this paper we consider the flow of two incompressible, viscous and immiscible fluids in a bounded domain, with different densities and viscosities. This model consists of a coupled system of Navier-Stokes and Mullins-Sekerka type parts,…

偏微分方程分析 · 数学 2025-05-13 Helmut Abels , Andrea Poiatti

In this paper we study nonlocal-to-local asymptotics for a tumor-growth model coupling a viscous Cahn-Hilliard equation describing the tumor proportion with a reaction-diffusion equation for the nutrient phase parameter. First, we prove…

偏微分方程分析 · 数学 2023-11-20 Elisa Davoli , Elisabetta Rocca , Luca Scarpa , Lara Trussardi

We investigate the general Porous Medium Equations with drift and source terms that model tumor growth. Incompressible limit of such models has been well-studied in the literature, where convergence of the density and pressure variables are…

偏微分方程分析 · 数学 2024-03-12 Jiajun Tong , Yuming Paul Zhang

We investigate the singular limit, as $\ep \to 0$, of the Fisher equation $\partial_t u=\ep \Delta u + \ep ^{-1}u(1-u)$ in the whole space. We consider initial data with compact support plus, possibly, perturbations very small as $\Vert x…

偏微分方程分析 · 数学 2009-10-13 Matthieu Alfaro , Arnaud Ducrot

We prove existence of weak solutions for a diffuse interface model for the flow of two viscous incompressible Newtonian fluids in a bounded domain in two and three space dimensions. In contrast to previous works, we study a new model…

偏微分方程分析 · 数学 2015-06-03 Helmut Abels , Daniel Depner , Harald Garcke

We consider the interaction between a free flowing fluid and a porous medium flow, where the free flowing fluid is described using the time dependent Stokes equations, and the porous medium flow is described using Darcy's law in the primal…

数值分析 · 数学 2022-10-05 Martina Bukač , Boris Muha , Abner J. Salgado