相关论文: Existence, Bifurcation, and Geometric Evolution of…
The Functionalized Cahn-Hilliard free energy supports phase separated morphologies of distinct codimension, including codimension-one bilayer and codimension-two filament morphologies. We characterize the linear stability of bilayer and…
Motivated by recent experimental work on multicomponent lipid membranes supported by colloidal scaffolds, we report an exhaustive theoretical investigation of the equilibrium configurations of binary mixtures on curved substrates. Starting…
Biomembranes and vesicles consisting of multiple phases can attain a multitude of shapes, undergoing complex shape transitions. We study a Cahn--Hilliard model on an evolving hypersurface coupled to Navier--Stokes equations on the surface…
We present a modified form of the Functionalized Cahn Hilliard (FCH) functional which models highly amphiphilic systems in solvent. A molecule is highly amphiphilic if the energy of a molecule isolated within the bulk solvent molecule is…
We focus on the derivation and analysis of a model for multi-component phase separation occurring on biological membranes, inspired by observations of lipid raft formation. The model integrates local membrane composition with local membrane…
The functionalized Cahn-Hilliard (FCH) equation supports planar and circular bilayer interfaces as equilibria which may lose their stability through the pearling bifurcation: a periodic, high-frequency, in-plane modulation of the bilayer…
We consider the mass preserving $L^2$-gradient flow of the strong scaling of the functionalized Cahn Hilliard gradient flow and establish the nonlinear stability of a manifold comprised of quasi-equilibrium bilayer \muckmucks up to the…
In this paper a generalization of the Cahn-Hilliard theory of binary liquids is presented for multi-component incompressible liquid mixtures. First, a thermodynamically consistent convection-diffusion type dynamics is derived on the basis…
We analyze the competitive evolution of codimension one and two morphologies within the $H^{-1}$ gradient flow of the strong Functionalized Cahn-Hilliard equation. On a slow time scale a sharp hypersurface reduction yields a degenerate…
The paper presents a complete research cycle comprising continuum-based modeling, computational framework development, and validation setup to predict phase separation and surface hydrodynamics in lipid bilayer membranes. We starting with…
Correctly formulated continuum models for lipid-bilayer membranes present a significant challenge to computational mechanics. In particular, the mid-surface behavior is that of a 2-dimensional fluid, while the membrane resists bending much…
We consider the formation of finite-size domains in lipid bilayers consisting of saturated and hybrid lipids. First, we describe a monolayer model that includes a coupling between a compositional scalar field and a two-dimensional vectorial…
We present a rigorous analysis of the transient evolution of nearly circular bilayer interfaces evolving under the thin interface limit, $\varepsilon\ll1$, of the mass preserving $L^2$-gradient flow of the strong scaling of the…
Amphiphilic polymers in aqueous solutions can self-assemble to form bilayer membranes, and their elastic properties can be captured by the well-known Helfrich model involving several elastic constants. In this paper, we employ the…
Experiments with diblock co-polymer melts display undulated bilayers that emanate from defects such as triple junctions and endcaps, \cite{batesjain_2004}. Undulated bilayers are characterized by oscillatory perturbations of the bilayer…
This article summarizes a variety of physical mechanisms proposed in the literature, which can generate micro- and nanodomains in multicomponent lipid bilayers and biomembranes. It mainly focusses on lipid-driven mechanisms that do not…
A coarse-grained molecular model, which consists of a spherical particle and an orientation vector, is proposed to simulate lipid membrane on a large length scale. The solvent is implicitly represented by an effective attractive interaction…
We study the effects of chiral constituent molecules on the macroscopic shapes attained by lipid bilayer membranes. Such fluid membranes are beautiful examples of statistical ensembles of random shapes, sometimes coupled to in-plane order.…
We study a model for lipid-bilayer membrane vesicles exhibiting phase separation, incorporating a phase field together with membrane fluidity and bending elasticity. We prove the existence of a plethora of equilibria in the large,…
Understanding the (de)mixing behavior of multicomponent lipid bilayers is an important step towards unraveling the nature of spatial composition heterogeneities in cellular membranes and their role in biological function. We use…