医学物理
Diffusion models (DMs) have recently been introduced as a regularizing prior for PET image reconstruction, integrating DMs trained on high-quality PET images with unsupervised schemes that condition on measured data. While these approaches…
The AMIAS/RISE framework formulates emission tomography as a probabilistic inverse problem in which reconstructed images are sampled from a distribution defined by the measurement model and counting statistics. In this work we present a…
Sparse-view computed tomography (CT) is an effective method to reduce the radiation exposure in medical imaging. To reduce the severe streaking artifacts that occur in reconstructed images due to violation of the Nyquist/Shannon sampling…
In this work, we investigate a fractional-order tumor growth model aimed at capturing memory effects and nonlocal temporal dynamics inherent to tumor evolution. The model is formulated using Caputo fractional derivatives and incorporates…
Dark-field imaging is widely used to infer fibre orientation from signal modulation as a function of sample orientation. However, current X-ray dark-field retrieval methods are restricted to single orientations and require tomography to…
Alzheimer's disease involves progressive tau accumulation and spread, leading to regional brain atrophy and disruption of large-scale functional networks. While tau propagation and tissue degeneration have been widely modeled, how atrophy…
Magnetic resonance elastography (MRE) and related elastography techniques are emerging as quantitative diagnostic tools for assessing tissue microstructure and pathology. To determine descriptive parameters of the tissues' properties, a…
Magnetic particle imaging (MPI) is a tracer-based technique that directly detects the distribution of magnetic iron-oxide nanoparticles with millisecond temporal resolution and no tissue background. Despite extensive preclinical work,…
Neuronal electrical activity underlies human cognition including perception, attention, memory, language, and decision-making. Yet its direct, noninvasive measurement in the living human brain remains a fundamental challenge. Existing…
Despite tremendous advances in cardiovascular medicine, significant opportunities remain to improve coronary artery disease (CAD) prevention and treatment strategies. The key limitation lies in the understanding of disease formation and…
Complex coronary bifurcation lesions remain challenging in percutaneous coronary intervention, with stent design and deployment strategy influencing clinical outcomes. This study compares the mechanical and hemodynamic performance of the…
Carbon ion therapy is one of the most advanced forms of radiotherapy, promising improved efficacy against resistant cancers. However, the high precision offered by the carbon ion Bragg peak requires precise knowledge of the beam range…
Magnetic Resonance Fingerprinting (MRF) and other highly accelerated transient-state parameter mapping techniques enable simultaneous quantification of multiple tissue properties, but often suffer from aliasing artifacts due to compressed…
The claim that Monte Carlo is the most accurate method is a case of misattributed credit. This claim is based on experience with advanced systems MCNPX, Geant4 and EGS. These systems achieve remarkable performance because they use most…
Clinical trials screening KRAS G12D protein for 30 pancreatic ductal adenocarcinoma (PDAC) patients and 30 healthy donors were conducted utilizing an AlGaN/GaN high electron mobility transistor (HEMT) biosensor. All resistance change ratios…
Background Double Kissing Crush (DKC) is a preferred two-stent technique for complex coronary bifurcation lesions. Proximal cell rewiring is routinely recommended to reduce technical failure, and DKC is considered effective across various…
We report the first in-air irradiations of biological samples with kHz laser-driven electrons with beam energy 20 MeV, high-energy tail extending to 40 MeV, and average dose rate up to 30 Gy/min. An in-house procedure has been developed to…
Synchrotron radiation-based X-ray microtomography is uniquely suited for post mortem three-dimensional visualization of organs such as the mouse brain. Tomographic imaging of the entire mouse brain with isotropic cellular resolution…
Modern science is dependent on imaging on the nanoscale, often achieved through processes that detect secondary electrons created by a highly focused incident charged particle beam. Multiple types of measurement noise limit the ultimate…
Voltage-sensitive fluorescence imaging is widely used to image action potential waves in the heart. However, while the electrical waves trigger mechanical contraction, imaging needs to be performed with pharmacologically…