医学物理
Artificial intelligence based radiomics models for thyroid ultrasound (US) often achieve strong diagnostic performance but remain difficult to interpret, limiting clinical trust and adoption. We developed and validated an interpretable…
Quantitative molecular imaging is central to treatment response assessment in oncology, yet clinical practice remains largely dominated by patient-level or limited target-lesion criteria that ignore inter-lesion heterogeneity. This…
Positronium Lifetime Imaging (PLI) extends positron emission tomography by using the lifetime of positronium atoms as a probe of tissue molecular architecture. In this work, we report the first PLI measurements performed with $^{52}$Mn and…
This study presents the first quantifications of ultrasound attenuation in oral soft tissues using validated standard techniques and serves as foundational step in advancing quantitative ultrasound (QUS) imaging in dentistry. Current…
Objective(s): T$_2$* and susceptibility ($\chi$) MRI mapping provide complimentary measures of the haemodynamic environment in the placenta. The aims of this work were to use these simultaneously obtained measures to investigate the role of…
Motivation: Quickly obtaining high-quality MRI from accelerated acquisitions is important to mitigate motion artifacts, maintain patient comfort, and improve clinical efficiency. Goals: To obtain high-quality dynamic MRI using efficient,…
Since the publication of our review article Hyperspectral imaging solutions for brain tissue metabolic and hemodynamic monitoring: past, current and future developments in 2018, the technological and applicational landscape of the use of…
This study presents the development and validation of an independent software tool based on the Varian Eclipse Scripting API (ESAPI) for multi-modal brachytherapy Quality Assurance (QA). The tool addresses GEC-ESTRO HDR protocols and LDR…
Objective: To assess the accuracy and computational performance of a stochastic differential equation (SDE)--based model for proton beam dose calculation by benchmarking against Geant4 in simplified phantom geometries. Approach: Building on…
Medicine is evolving beyond therapy largely predicated on anatomical information and towards incorporating patient-specific molecular biomarkers of disease for more accurate diagnosis and effective treatment. The complementary combination…
Objectives: This study aims to characterize the dose-performance relationship for opportunistic CT and disentangle the contributions of segmentation failure and dose-dependent HU bias to performance degradation. Methods: Simulated low-dose…
In patients with biochemical recurrence of prostate cancer and negative PSMA PET/CT, radiomics features extracted from recurrence-prone organs can predict clinical progression and progression-free survival. In a cohort of 132 patients,…
Objective: The percentage of long-term survival in out of hospital cardiac arrest cases is remarkably low. One approach would be to increase the effectiveness of cardiopulmonary resuscitation (CPR), which is currently not measurable in a…
Particle therapy relies on up-to-date knowledge of the stopping power of the patient tissues to deliver the prescribed dose distribution. The stopping power describes the average particle motion, which is encoded in the distribution of…
Osteoporosis, a major global epidemic, often goes undetected until a fracture occurs, largely due to poor access to screening using gold standard methods, such as dual-energy X-ray absorptiometry (DXA). As a potential nonionizing radiation…
Assume you encounter an inverse problem that shall be solved for a large number of data, but no ground-truth data is available. To emulate this encounter, in this study, we assume it is unknown how to solve the imaging problem of Computed…
Purpose: The clinical feasibility and translation of many advanced quantitative MRI (qMRI) techniques are inhibited by their restriction to 'research mode', due to resource-intensive, offline parameter estimation. This work aimed to achieve…
We consider physics behind the FLASH modality of cancer radiation treatment where extremely short treatment times are achieved with ultra high dose rates maintaining the conventional antitumor effectiveness and yet substantially reducing…
Very high energy electrons (VHEE) in the 50-250 MeV range, delivered in short pulses at ultra-high dose rates, are proposed for clinical FLASH radiotherapy (RT) targeting deep-seated tumors. The clinical implementation of VHEE-FLASH RT…
In biological tissue, MR transverse relaxation stems from mechanisms spanning multiple scales, from molecular dipole-dipole interactions to mesoscopic field variations driven by tissue microstructure. While mesoscopic relaxation reflects…