医学物理
Rapid and accessible cardiac biomarker testing is essential for the timely diagnosis and risk assessment of myocardial infarction (MI) and heart failure (HF), two interrelated conditions that frequently coexist and drive recurrent…
Positron emission tomography (PET) enables quantification of dynamic physiological processes through time-resolved imaging. In Rb-82 myocardial perfusion PET, kinetic compartment modeling is used to estimate physiological parameters and…
To optimize diffusion MRI acquisition protocols for IMPULSED model at clinical 3T scanner using Bayesian experimental design, enabling accurate cellular-scale parameter estimation under realistic scan time and scanner hardware constraints.…
We present an experimental setup and methodology designed to facilitate high-precision thermal measurements required for infrared medical tomography. The approach which is best suited for the study of specialized hardware phantoms comprises…
Breath acetone represents a promising non-invasive biomarker for monitoring fat oxidation during exercise. However, its utility is limited by confounding factors, as well as by the fact that significant changes in concentration occur only…
Correction for nearsightedness and farsightedness is an important concern for functional magnetic resonance imaging (fMRI) experiments involving visual stimuli in humans. In the absence of personal contact lenses, spherical refractive…
Purpose of Review Imaging derived fractional flow reserve (FFR) is rapidly evolving beyond conventional computational fluid dynamics (CFD) based pipelines toward machine learning (ML), deep learning (DL), and physics informed approaches…
Spatially Fractionated Radiation Therapy (SFRT) or GRID therapy has been in existence for more than a century. GRID therapy was invented as an approach to address the challenges posed by bulky tumors. To treat patients with GRID therapy,…
Large language models (LLMs) have emerged as transformative tools in medicine, with strong capabilities in language understanding, reasoning, and structured information extraction. Radiation oncology is particularly well suited for LLM…
Conventional 2D fluorescence imaging in glioma surgery cannot separate intrinsic fluorophore strength from attenuation with depth, creating depth-intensity ambiguity that can compromise assessment of residual tumour and fluorescence based…
Ultra-low-field (ULF, <0.1 T) magnetic resonance imaging (MRI) systems offer advantages in cost, portability, and accessibility, but their current utility is still limited by low signal-to-noise ratio (SNR). Deep learning (DL)-based…
We present a proof of concept for screening breast cancer risk by detecting biochemical alterations in breast tissue using a noninvasive and low-cost technique that uses dynamic light scattering for field effect detection by spectral…
Advances in instrumentation and computation have enabled increasingly sophisticated tomographic reconstruction methods. However, existing evaluation practices -- often based on simple phantoms and global image metrics -- are limited in…
Vascular diseases such as atherosclerosis, thrombosis, and aneurysms can lead to life-threatening medical events. Conventional catheter- or guidewire-based interventional devices often struggle to navigate through highly tortuous…
Introduction: Terbium-149 ($^{149}$Tb) is a promising radionuclide for targeted $\alpha$ therapy that has a non-zero branching ratio (BR) for positron decay. However, its relatively low positron branching fraction and multiple prompt…
Scapulohumeral rhythm (SHR), the coordinated motion between the scapula and humerus during arm elevation, is frequently altered in rotator cuff pathologies, yet the mechanical principles underlying coordination redistribution remain…
Introduction High performance gradients poses a promise for breast diffusion weighted imaging (DWI) but are restricted by physiological limits in whole body scanners. While local nonlinear coils offer higher amplitudes, they often suffer…
Surface-guided radiation therapy (SGRT) is now widely used for radiation-dose-free, marker-free patient positioning in modern radiotherapy. We commissioned and clinically implemented a novel SGRT system, LUNA 3D (LAP, Lueneburg, Germany),…
Diffusion-weighted imaging (DWI) in the female breast is a magnetic resonance imaging (MRI) technique, which may potentially replace or effectively complement both x-ray mammography and contrast-enhanced MR mammography. To further improve…
Background: Renal blood flow (RBF) is an important marker of kidney health, but noninvasive assessment is not routinely used in clinical imaging. We evaluated the feasibility and physiologic validity of quantifying renal transport of…