医学物理
Magnetocardiography system is a medical device that diagnoses cardiac disease by measuring magnetic fields generated from electric currents flowing through the myocardium. However, the accuracy of measurement data can be degraded if strong…
Continuous ambulatory monitoring of peripheral vascular perfusion could enable earlier detection of vascular dysfunction in individuals with diabetes mellitus and more timely management of cardiovascular disease. Clinical imaging modalities…
Several applications of medical ultrasound can benefit from a larger field of view (FOV). This study is aimed at increasing the FOV of linear array probes by increasing the element width. Coupled elements were used to imitate a larger…
Purpose: Novel MR sequence developments still today allow generation of new diagnostic tools or novel imaging biomarkers. Programming MRI pulse sequences, however, is time-consuming and requires deep expertise in sequence design,…
Objectives: Existing voxel-based dose converters transform hypofractionated dose distributions into biologically effective dose (BED) or equivalent dose in 2 Gy fractions (EQD2), but they are not reliably applicable to organ-at-risk (OAR)…
Conventional colorimetric sensing methods typically rely on signal intensity at a single wavelength, often selected heuristically based on peak visual modulation. This approach overlooks the structured information embedded in full-spectrum…
In proton therapy of low-grade glioma (LGG) patients, contrast-enhancing brain lesions (CEBLs) on magnetic resonance imaging are considered predictive of late radiation-induced lesions. From the observation that CEBLs tend to concentrate in…
Purpose: Accurate dose calculation is essential in radiotherapy for precise tumor irradiation while sparing healthy tissue. With the growing adoption of MRI-guided and real-time adaptive radiotherapy, fast and accurate dose calculation on…
Purpose: Recent investigations of radiation-induced contrast enhancements (RICE) in brain tumor patients after proton therapy indicated variability in proton relative biological effectiveness (RBE) and increased radiosensitivity of the…
Background: Positronium lifetime imaging extends conventional positron emission tomography by using the time interval between positron emission and annihilation as an additional contrast mechanism. Voxel-wise lifetime estimation in fully…
Purpose: To improve the accuracy of diffusion-weighted powder average signals for diffusion encoding with arbitrary b-tensors. Methods: We identify an intrinsic dihedral ($D_2$) symmetry of diffusion signals for arbitrary diffusion…
Positronium Lifetime Imaging (PLI), an emerging extension of conventional positron emission tomography (PET) imaging, offers a novel window for probing the submolecular properties of biological tissues by imaging the mean lifetime of the…
Larmor frequency shifts in white matter (WM) vary with fiber orientation due to anisotropic microstructure. Since clinical voxels are significantly larger than these microscopic frequency variations, the measured signal represents a bulk…
Transmit Array Spatial Encoding (TRASE) is an MRI technique in which spatial encoding is achieved using phase gradients of the B1 field. This approach offers potential advantages such as hardware simplicity and reduced acoustic noise. In…
Cost-effective wireless electrocardiograms (ECGs) enable long-term and scalable monitoring of cardiac patients in their home and work environments. Because they offer greater freedom of movement, they are also suitable for investigating the…
Clinical decisions for unruptured intracranial aneurysms depend on detecting growth on follow-up magnetic resonance angiography (MRA). Growth is typically judged from manual 2D diameters on few slices, which vary across clinicians and…
For accurate disease characterization using positron emission tomography (PET), it is desirable to image multiple radiotracers in a single scan. Conventional PET methods cannot do this due to the indistinguishable annihilation photons…
Time-resolved volumetric MR imaging that reconstructs a 3D MRI within sub-seconds to resolve deformable motion is essential for motion-adaptive radiotherapy. Representing patient anatomy and associated motion fields as 3D Gaussians, we…
Purpose: To develop and evaluate DosimeTron, an agentic AI system for automated patient-specific MC internal radiation dosimetry in PET/CT examinations. Materials and Methods: In this retrospective study, DosimeTron was evaluated on a…
Purpose: Volumetric ultrafast ultrasound produces massive datasets with high frame rates, dense reconstruction grids, and large channel counts. Beamforming computational demands limit research throughput and prevent real-time applications…