医学物理
Objective: To validate a novel inter-electrode pulse wave velocity (PWV) method that measures pulse propagation between ECG electrodes without left ventricular ejection time (LVET) estimation. Methods: We analyzed 43 three-channel ECG…
Configuring clinical linear accelerators (linacs) for ultra-high dose rate (UHDR) electron experiments typically requires invasive hardware manipulation and/or irreversible manufacturer modifications, limiting broader implementation. We…
Targeted Radionuclide Therapy (TRT) is a well-established technique for cancer treatment. In this approach, radionuclides are bound to specific drugs that selectively transport them to the tumor site. Within the ISOLPHARM project, a…
Purpose: Widespread adoption and methodological advancement of Magnetic Resonance Fingerprinting (MRF) are limited by the lack of unified, reproducible implementation frameworks and fragmented open-source tools. To address these barriers,…
Drug delivery to the brain is limited by the blood-brain barrier (BBB). We developed a capacitive micromachined ultrasonic transducer (CMUT)-based transcranial focused ultrasound system capable of both delivering therapy via BBB opening and…
Row column addressed (RCA) transducers present a promising solution for ultrafast volumetric imaging with a reduced channel count and a large field of view. However, RCA-based 3D imaging is fundamentally limited by severe sidelobe artifacts…
Optical imaging and spectroscopy solutions, such as near-infrared spectroscopy (NIRS) and diffuse optical tomography (DOT), have the potential to provide compact, bedside monitoring of the placenta in the clinic, thanks to recent…
Continuous monitoring of physiological signals is essential for the early detection of health problems. A measurement system that ensures high sensitivity, accuracy, and user comfort is needed. In this study, we designed and optimized a…
Vision Transformers (ViTs) have shown strong empirical performance on high-dimensional medical imaging data, yet their behavior under survival objectives and the interpretability of their attention mechanisms remain poorly understood. Under…
Traditional X-ray computed tomography (CT) scanning strategies typically select projection angles uniformly and allocate dose equally. In practice, however, CT scans often need to be fast, radiation-efficient, and adaptive. Sparse-view…
Accurate identification of EGFR and KRAS mutations is essential for precision therapy in non-small cell lung cancer (NSCLC), but tissue genotyping is invasive and may not capture tumor heterogeneity. CT-based radiogenomics offers a…
Computed ultrasound tomography in echo mode generates maps of tissue speed of sound (SoS) from the shift of echoes when detected under varying steering angles. It solves a linearized inverse problem that requires regularization to…
Purpose: Quasi-random Sobol-based sampling schemes exhibit deterministic structural artifacts when aggressively undersampled, particularly at low encoding densities required for accelerated 2D SPI/CSI. To address these limitations, two…
Accurate assessment of corneal mechanical properties is critical for understanding ocular biomechanics, predicting refractive surgery outcomes, and optimizing cross-linking (CXL) treatments. Conventional uniaxial tensile test is limited by…
The LEOPs (Light-ERG-Oscillatory Potentials) dataset provides light-adapted (LA) electroretinogram (ERG) and Oscillatory Potentials (OPs) waveforms for typically developing Control, Autism Spectrum Disorder (ASD) and ASD + Attention Deficit…
In this Comment, we discuss recent approaches to electromagnetic interference (EMI) mitigation in low-field Magnetic Resonance Imaging (LF-MRI), as presented in arXiv preprints 2509.05955v1, 2406.17804v3, or 2210.06730v2. These and other…
Patient-specific computational models of the heart are powerful tools for cardiovascular research and medicine, with demonstrated applications in treatment planning, device evaluation, and surgical decision-making. Yet constructing such…
Prompt Gamma Timing (PGT) is a promising technique for in vivo range verification in particle therapy, exploiting the time-of-flight between primary particles and prompt gamma rays emitted by nuclear interactions. PGT distribution is highly…
{\bf Purpose}: To develop a geometry-governed diffusion framework that explains differential tissue response under FLASH ultra-high dose rate (UHDR) irradiation by explicitly accounting for structural heterogeneity and anomalous transport…
We developed a deep learning-based model observer (DLMO) to evaluate a multi-coil sensitivity encoding parallel MRI system at different accelerations on the Rayleigh discrimination task as a surrogate measure of resolution. We inserted…