医学物理
Thrombotic vascular diseases contribute to significant global mortality, yet current therapeutic strategies face persistent challenges including bleeding risks, suboptimal efficiency, and procedural complexity. Here, we report a…
Commercial treatment planning systems for electron FLASH radiotherapy are unavailable, and the dosimetric precision required for ultra-high dose rate delivery makes Monte Carlo (MC) simulation the gold standard approach. This work…
Skull-induced aberrations remain a major drawback of transcranial ultrasound localization microscopy (ULM), degrading sensitivity and spatial accuracy through microbubble mislocalization, false detections, and imaging artifacts, such as…
In pulse-echo ultrasound, aberration often degrades image quality when beamforming does not account for wavefront distortions. To address this issue, local sound speed estimators have been developed in the past decade for distributed…
Wave propagation through complex poroelastic multilayered media is difficult to model and invert because pronounced heterogeneity, scattering, mode conversion and fluid-solid coupling jointly distort acoustic signals during propagation.…
This study develops and validates a patient-specific Monte Carlo (MC) dosimetry framework for propagation-based phase-contrast breast CT (BCT) at the Imaging and Medical Beamline (IMBL), ANSTO Australian Synchrotron, for accurate mean…
The neutron shielding properties of high-density concrete and magnetite aggregates were evaluated using both experimental measurements and Monte Carlo simulations. Because these materials are commonly used in medical accelerator facilities,…
The lack of analytical models describing diffusion time dependence at intermediate time scales in complex tissue microstructure limits the accurate quantification of extracellular diffusivity and tissue microstructure. We introduce TRACED,…
Applicator-specific phase space (PHSP) files recorded at the aperture exit reduce Monte Carlo dose calculation time by 30-50% for electron FLASH radiotherapy. However, positioning PHSP scoring planes coincident with the applicator-air…
Transmembrane water permeability, which regulates cellular water exchange and is influenced by water channels such as aquaporin-4 (AQP4), has been implicated in glioma progression and may affect tumour infiltration and treatment response.…
Grating interferometry is a promising diagnostic technique that enables simultaneous acquisition of three complementary, synergistic X-ray images: transmission, differential phase, and dark-field. Its key advantage over other setups is its…
This manuscript introduces a novel method to assess tissue oxygen concentration via the quantum entanglement (QE) of photons originating from positronium which is produced within the patient's body during positron emission tomography. We…
Purpose: To develop a robust deep learning framework for non-contrast-enhanced functional lung MRI, overcoming the limitations of spectral decomposition in the presence of physiological non-stationarity. Methods: We introduce VQ-Wave…
Purpose: As interest in CEST-MRI grows, particularly in the preclinical setting, the necessity for standardized and easy-to-use acquisition and data analysis pipelines has become apparent. While vendors have increasingly introduced support…
The ramp filter kernel and cutoff frequency are fundamental parameters of the Feldkamp-Davis-Kress (FDK) algorithm that determine the resolution and noise characteristics of the reconstructed image. Despite their importance, systematic…
Treatment-related lymphopenia is a frequent and clinically significant consequence of cancer therapy that can compromise immune-mediated tumor control and worsen patient outcomes. Despite its importance, no mechanistic framework exists to…
A deep learning model is proposed for reconstructing 2D dielectric breast images from time-domain signals. Unlike existing learning models that employ a fixed antenna array, where input data consists solely of measurements, the proposed…
In conventional radiotherapy, the probability of controlling tumor growth is quantified using Tumor Control Probability (TCP) models. Instead, the probability of experiencing a side effect after the irradiation of healthy tissues and organs…
Sound speed heterogeneities can create aberrations in B-mode ultrasound images by inducing tissue-dependent delays and diffractive effects that conventional beamforming does not incorporate. By using the Fourier split-step method to…
Biophysical diffusion MRI models like Neurite Exchange Imaging (NEXI) are essential for probing gray matter microstructure, estimating compartment diffusivities, neurite fraction, and exchange time. However, NEXI's multi-shell,…