基于液态碱金属的可注射热化学微爆炸用于快速栓塞溶解
医学物理
2026-05-08 v1
摘要
栓塞性血管疾病导致全球死亡率显著增加，但现有治疗策略面临出血风险、效率不佳和程序复杂等持续挑战。本文报道了一种通过注入液态碱金属（LAM）封装于二甲基硅油中的微型爆炸热化学栓塞溶解（METCT）治疗方案，实现了在极快时间范围内（< 90 秒）的高效、安全的血管再通。该LAM@油系统通过三联作用机制有效破坏栓塞组织：机械微爆炸力、由于高度局部化热化学反应产生的碱性消解，以及由升温介导的热裂解。栓塞溶解完成后，产生的非毒性反应副产物（氢氖和钾离子）表现出生理上生物相容且可代谢的效应。关键在于，LAM@油的栓塞溶解疗效显著高于临床可用的栓塞溶解药物（LAM@油残余栓塞面积百分比为10.87%+-7.16%，而尿激酶为80.86%+-13.32%），且无出血风险。该策略为一种无副产物、高效且成本效益好的传统栓塞溶解药物提供了潜在的临床转化路径，具有广泛的急性栓塞管理应用前景。
引用
@article{arxiv.2605.05924,
title = {Injectable Thermochemical Micro-Explosion for Prompt Thrombolysis via Liquid Alkali Metal},
author = {Xin Liao and Yi Hou and Jie Zhang and Bo Wang and Minghui Guo and Hua Qu and Wei Rao and Jing Liu},
journal= {arXiv preprint arXiv:2605.05924},
year = {2026}
}
备注
25 pages, 6 figures. This article was originally submitted to Advanced Materials in September 2025 and has been reviewed twice and then recommended to Advanced Science for publication by offering no further need of external peer review and has been with the journal with all updated documents since January 23, 2026