医学物理
Radiation therapy (RT) requires precise dose delivery over multiple fractions, with CT fundamental for treatment planning due to its electron density information. Repeated CT acquisitions impose radiation exposure and logistical burdens,…
Radiotherapy (RT) patient scheduling is a complex operational problem. Current scheduling often relies on manual coordination and can be difficult to adapt to changing clinical demands. This study evaluated the feasibility of using a large…
Traditional VMAT optimization often ignores dynamic machine limits, treating delivery time as an emergent property rather than a steerable parameter. This work introduces Dynamic Modulated Arc Therapy (DMAT), an intent-driven framework that…
Quantifying hemodynamics in the curved segments of the intracranial internal carotid artery is a core challenge in diagnosing vascular stenosis. Conventional full-field imaging, such as 4D Flow MRI, is costly and difficult to widely…
Patient derived xenograft (PDX) tumor models initiated in avian chorioallantoic membranes (CAM) are under investigation to evaluate the effectiveness of therapeutic options with the objective of personalizing treatments. CAM PDXs paired…
Introduction: Real-time dosimetry of surface doses in electron beams has not been widely established yet. Plastic scintillation detectors (PSD) promise high spatial resolution and real-time dosimetry with minimum perturbation of the…
Many lung diseases require detailed visualisation for accurate diagnosis and treatment. High-resolution computed tomography (CT) is the gold-standard technique for non-invasive lung disease detection, but it presents a risk to the patient…
X-ray imaging is a fast, precise and non-invasive method of imaging which, when combined with computed tomography, provides detailed 3D rendering of samples. Incorporating propagation-based phase contrast can vastly improve data quality for…
Spatially fractionated radiation therapy (SFRT) planning requires three coordinated tasks: generation of high-dose sphere structures, position-aware optimization, and peak-valley dose ratio evaluation. We present MAAS-SFRThelper, a…
Purpose: Following the clinical success of 177Lu-based therapies, accurate quantification of 177Lu using radionuclide calibrators (RNCs) and SPECT/CT is gaining importance as prerequisite for accurate treatment delivery and dosimetry.…
Current magnetic resonance imaging (MRI) requires the subject to remain stationary to limit motion artifacts and avoid unwanted field-induced brain stimulation. However, imaging during large-scale motion could enable studies in which motion…
Quantifying muscle tissue properties is crucial for understanding pathophysiological changes occurring in skeletal muscle (SM). In particular, T2 relaxation and diffusion MRI (dMRI) are promising techniques. However, typical methods measure…
Purpose: Diffusion MRI has shown promise for breast cancer screening, lesion characterization,and treatment response monitoring without contrast agents, but further translation is constraint by the gradient performance of conventional…
White matter hyperintensities (WMH) are bright regions on T2-weighted magnetic resonance imaging (MRI) scans and are associated with cerebrovascular pathology and neurodegeneration, including myelin loss. While Luxol Fast Blue…
Body fat percentage and its spatial distribution are clinically important health indicators. However, existing measurement methods often impose a tradeoff between accuracy and accessibility. Clinical-grade techniques, such as Dual-Energy…
Inter-crystal scattering (ICS) in Positron Emission Tomography (PET) is commonly regarded as a degradation effect that might compromise the image spatial resolution. In parallel, the inclusion of ICS events has also been recognized as a…
Many minimally invasive procedures, such as core needle biopsy of focal liver lesions, nerve blocks, and fetal and vascular interventions, are typically performed under ultrasound guidance, which provides real-time, high-resolution…
Deep learning-based organs/structures-at-risk(OARs) auto-contouring models can improve radiotherapy workflows, but models trained on adult data often underperform in pediatric patients. Developing robust pediatric-specific models is…
The John equation serves as the mathematical foundation of the X-ray transform, describing the intrinsic compatibility conditions that projection data must satisfy. In this paper, within three-dimensional (3D) Euclidean space, an innovative…
Objective: To enable reliable smartphone-based hearing assessments by developing methods to estimate device calibration offsets using categorical loudness scaling (CLS). Design: Calibration offsets were simulated from a Gaussian…