医学物理
Accurate volumetric velocity estimation is crucial in ultrasound imaging for both diagnostic and therapeutic applications. Traditional ultrasound systems, though effective for two-dimensional imaging, face major limitations in 3D imaging…
Proton therapy has been rapidly advancing due to its excellent conformal index, but its relatively low relative biological effect (RBE) has somewhat limited its therapeutic efficacy for certain tumors. To address this, we previously…
The 3D fast silent multi-parametric mapping sequence with zero echo time (MuPa-ZTE) is a novel quantitative MRI (qMRI) acquisition that enables nearly silent scanning by using a 3D phyllotaxis sampling scheme. MuPa-ZTE improves patient…
Computational models are continuously integrated in the clinical space, where they support clinicians in disease diagnosis, prognosis, and prevention strategies. While assisting in clinical space, these computational models frequently use…
Attenuation correction (AC) is necessary for accurate activity quantification in positron emission tomography (PET). Conventional reconstruction methods typically rely on attenuation maps derived from a co-registered computed tomography…
The use of very high energy electron (VHEE) beams for radiotherapy has been actively studied for over two decades due to their advantageous dose distribution, deep penetration depth and great potential of ultra-high dose-rate irradiation.…
Objective: This study aims to investigate the influence of organ architecture (specifically the distinction between serial and parallel tissue) on the protective FLASH effect when organs are irradiated with inhomogeneous dose distributions.…
Dual-energy computed tomography (DECT) enables material-specific imaging through acquisitions at two different X-ray energy spectra. Material decomposition from DECT data is an ill-posed inverse problem that is highly sensitive to noise…
An explicit positronium (Ps) source model was implemented in Geant4 to provide direct event-level control over annihilation channel selection, decay timing, and photon emission topology. The implementation supports direct annihilation,…
The widespread use of disposable facemasks during the COVID-19 pandemic has led to environmental widespread concern due to microplastic pollution. Biodegradable disposable facemasks are a first step to reducing the environmental impact of…
FLASH radiotherapy (FLASH-RT) has shown the potential to spare normal tissue while seemingly maintaining the effectiveness of conventional radiotherapy (CONV-RT). It has been suggested that the protective effect arises from the radiolytic…
Purpose: To present a methodology to analyze the variation of RBE with fractionation from clinical data of tumor control probability (TCP) and to apply it to study the response of prostate cancer to proton therapy. M&M: We analyzed the…
Proton therapy exploits the finite range of charged particles in tissue to achieve dose distributions no photon based modality can replicate. Yet the modality reaches fewer than 1 percent of patients who might benefit a gap rooted in cost…
Background: Clinical linear accelerators are an accessible platform for preclinical research on the biological effects of ultra rapid electron irradiation (FLASH). However, they are not inherently designed for the accurate pulse control…
Quantitative post-treatment activity imaging is essential for personalised dosimetry after Yttrium-90 selective internal radiation therapy (SIRT). Yttrium-90 PET offers high spatial resolution but is extremely low-count, whereas…
Radiotherapy with Very High Energy Electron (VHEE) beams is being extensively investigated for the treatment of deep-seated tumours, even in view of novel protocols based on the so-called FLASH effect. Laser WakeField Acceleration (LWFA)…
Short-scan FDK reconstruction is widely used in preclinical cone-beam micro-CT because it reduces scan time and radiation dose, and because the large volume sizes typical of micro-CT make iterative methods impractical for routine use. Short…
Low-field MRI is increasingly considered accessible for imaging owing to its lower cost, simpler infrastructure requirements, and potential for mobile and point-of-care deployment. A central challenge is achieving clinically useful field…
Preclinical micro-CT reconstruction involves large projection sizes and volumes that make iterative methods costly - 5x to 50x slower than analytic alternatives on modern GPUs. Whether this cost is justified depends on the imaging task, yet…
Objective: Triaxial accelerometers (TAAs) are widely used in homecare medicine. This study investigates whether TAA signals recorded at the fingertip encode respiratory information, particularly instantaneous respiratory rate (IRR) and…