医学物理
We characterize the amplitude statistics of intraoperative microelectrode recordings (MERs) obtained during deep brain stimulation (DBS) surgery in 46 patients with Parkinson's disease, using 184 recordings equally balanced between inside…
Objective evaluation of quantitative imaging (QI) methods with patient data is often hindered by the lack of gold standards. To address this challenge, a class of regression-without-truth (RWT) techniques have been developed. These…
Clinical translation of quantitative imaging (QI) methods requires objective evaluation of these methods on reliably measuring the underlying true quantitative values. Ideally, such evaluation would be performed using ground truth or gold…
Computational models of cardiac structure and function are increasingly central to the development of subject-specific cardiac digital twins, enabling improved characterization of contractile dysfunction, pathological remodeling, and…
Three intra-aortic blood pumps were evaluated and compared using CFD simulations. The aim of this study is to evaluate the hemodynamic performance and calculate the hemolytic potential of the pumps. The flow fields generated by the pumps…
Purpose: This work proposes a method for the simultaneous estimation of the exchange-dependent relaxation rate Rex and the longitudinal relaxation time T1 from a single acquisition. Methods: A novel acquisition scheme was developed that…
Photon-counting computed tomography has demonstrated significant advancements in recent years; however, micro photon-counting CT (Micro-PCCT) systems are still limited by pixel-wise detector response nonuniformity, which degrades…
Purpose: To develop a rapid, high-resolution and distortion-free technique for simultaneous water-fat separation, $R_{2}^{*}$ and $B_{0}$ mapping of the fetal brain at 3T. Methods: A 2D multi-echo radial FLASH sequence with blip gradients…
Recent advances in propagation-based phase-contrast imaging, such as hierarchical imaging, have enabled the visualization of internal structures in large biological specimens and material samples. However, modulation-based techniques, which…
This paper describes the development of a novel medical Xray imaging system adapted to the needs and constraints of low and middle income countries. The developed system is based on an indirect conversion chain: a scintillator plate…
Background: Right anomalous aortic origin of coronary arteries (R-AAOCA) involves fixed compression, assessable with adenosine-derived fractional flow reserve (FFRAdnosine), and additional stress-induced dynamic compression captured by…
Purpose: To create modular solutions for interactive real-time MRI using reconstruction algorithms implemented in BART. Methods: A new protocol for streaming of multidimensional arrays is presented and integrated into BART. The new…
Introduction: We describe the foundation of PETRIC, an image reconstruction challenge to minimise the computational runtime of related algorithms for Positron Emission Tomography (PET). Purpose: Although several similar challenges are…
Purpose: To develop a motion-robust and geometrically-accurate quantitative CEST approach using radial k-space sampling, locally low-rank reconstruction and neural network quantification. Methods: The acquisition schedule was generated via…
Functional near-infrared spectroscopy (fNIRS) is impacted by signal contamination from superficial hemodynamics. It is important to develop methods that account for such contamination and provide accurate measurements of cerebral…
Treatment planning in radiotherapy is inherently a multi-criteria optimization (MCO) problem. Traditionally, the treatment's robustness is not formulated as a part of this decision making problem, but dealt with separately through margins…
Clinical imaging is routinely used for cochlear implant surgical planning yet lacks the resolution and contrast necessary to visualize the fine intracochlear structures critical for individualized intervention. To address this limitation,…
Accurate modeling of ultrasound wave propagation is essential for high-fidelity simulation and imaging in ultrasonic testing. A primary challenge lies in characterizing the excitation source, particularly for transducers with large…
Three-dimensional (3D) photoacoustic computed tomography (PACT) is a powerful noninvasive biomedical imaging modality that provides volumetric data for structural and functional assessment \textit{in vivo}. To maximize angular coverage and…
Pulsed-gradient spin-echo (PGSE) MRI experiments probe molecular self-diffusion through spin phase accumulation under time-dependent magnetic field gradients. For diffusion confined to cylindrical surfaces, existing analytical signal models…