English

Shot noise-mitigated secondary electron imaging with ion count-aided microscopy

Medical Physics 2026-03-12 v2 Applied Physics Data Analysis, Statistics and Probability Instrumentation and Detectors

Abstract

Modern science is dependent on imaging on the nanoscale, often achieved through processes that detect secondary electrons created by a highly focused incident charged particle beam. Multiple types of measurement noise limit the ultimate trade-off between the image quality and the incident particle dose, which can preclude useful imaging of dose-sensitive samples. Existing methods to improve image quality do not fundamentally mitigate the noise sources. Furthermore, barriers to assigning a physically meaningful scale make the images qualitative. Here we introduce ion count-aided microscopy (ICAM), which is a quantitative imaging technique that uses statistically principled estimation of the secondary electron yield. With a readily implemented change in data collection, ICAM substantially reduces source shot noise. In helium ion microscopy, we demonstrate 3x dose reduction and a good match between these empirical results and theoretical performance predictions. ICAM facilitates imaging of fragile samples and may make imaging with heavier particles more attractive.

Keywords

Cite

@article{arxiv.2311.07003,
  title  = {Shot noise-mitigated secondary electron imaging with ion count-aided microscopy},
  author = {Akshay Agarwal and Leila Kasaei and Xinglin He and Ruangrawee Kitichotkul and Oguz Kagan Hitit and Minxu Peng and J. Albert Schultz and Leonard C. Feldman and Vivek K Goyal},
  journal= {arXiv preprint arXiv:2311.07003},
  year   = {2026}
}

Comments

Updated Introduction, Updated Discussion and Outlook, Updated Methods. Main article: 17 pages, 4 figures

R2 v1 2026-06-28T13:18:47.152Z